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The enhancement by dietary zinc deficiency of the susceptibility of the rat duodenum to colchicine

Published online by Cambridge University Press:  06 August 2007

D. Dinsdale  and
R. B. Williams
D. Dinsdale
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen, AB2 9SB
R. B. Williams
Affiliation:
The Rowett Research Institute, Bucksburn, Aberdeen, AB2 9SB
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Abstract

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1. The incidence of colchicine-induced lesions in the germinal epithelium of the rat duodenum was studied in young rats in an early stage of zinc deficiency and in their pair-fed controls. At both dose levels of colchicine used, a marked increase in the amount of cell damage was observed in the duodenum of Zn-deficient rats as compared with the pair-fed, control (Zn-supplemented) rats.

2. No statistical interaction between Zn and colchicine was demonstrable, and no lesions were found in the duodenum of animals that had not been treated with colchicine.

3. The results are discussed in relation to the effects of Zn deficiency in animals and the possible involvement of Zn in the maintenance of the integrity of microtubular structures.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 37 , Issue 1 , January 1977 , pp. 135 - 142
Copyright
Copyright © The Nutrition Society 1977

References

REFERENCES

Affonso, O., Mitidieri, E. & Villela, G. G. (1961). Nature, Lond. 192, 666.CrossRefGoogle Scholar
Affonso, O., Mitidieri, E. & Villela, G. G. (1962). Nature, Lond. 193, 640.CrossRefGoogle Scholar
Alov, I. A. (1963). Fedn. Proc. Fedn. Am. Socs. exp. Biol. Med. 22, T357.Google Scholar
Back, A., Walaszek, E. J. & Uyeki, E. (1951). Proc. Soc. exp. Biol. Med. 77, 667.CrossRefGoogle Scholar
Borisy, G. G. & Taylor, E. W. (1967 a). J. Cell Biol. 34, 525.CrossRefGoogle Scholar
Borisy, G. G. & Taylor, E. W. (1967 b). J. Cell Biol. 34, 535.CrossRefGoogle Scholar
Chesters, J. K. (1974). In Trace Element Metabolism in Animals. Vol. 2, pp. 39–50 [Hoekstra, W., Suttie, G., Ganther, J. W., Mertz, H. E. W., editors]. Baltimore: University Park Press.Google Scholar
Clearkin, P. A. (1937). J. Path. Bact. 44, 469.CrossRefGoogle Scholar
Diamond, I. & Hurley, L. S. (1970). J. Nutr. 100, 325.CrossRefGoogle Scholar
Dinsdale, D. (1975). Path. Eur. 10, 95.Google Scholar
Ebner, H. & Strecker, H. (1950). Experientia 6, 388.CrossRefGoogle Scholar
Edstrom, A. & Mattson, H. (1975). Brain Res. 86, 162.CrossRefGoogle Scholar
Eigsti, O. J. & Dustin, P. (1955). In Agriculture Medicine, Biology and Chemistry, p. 175. Ames, Iowa: Iowa State College Press.CrossRefGoogle Scholar
Elmes, M. E. (1974). Studies on the role of the Paneth cell in zinc metabolism in the rat. PhD Thesis, Queen's University of Belfast, Northern Ireland.Google Scholar
Fell, B. F., Leigh, L. C. & Williams, R. B. (1973). Res. vet. Sci. 14, 317.CrossRefGoogle Scholar
Fujii, T. (1954). Nature, Lond. 174, 1108.CrossRefGoogle Scholar
Fujii, T. (1955). J. Fac. Sci. Tokyo Univ. 7, 313.Google Scholar
Fujioka, M. & Lieberman, I. (1964). J. biol. Chem. 239, 1164.CrossRefGoogle Scholar
Hurley, L. S. & Swenerton, H. (1966). Proc. Soc. exp. Biol. Med. 123, 692.CrossRefGoogle Scholar
Kerr, J. F. R., Wyllie, A. H. & Currie, A. R. (1972). Br. J. Cancer 26, 239.CrossRefGoogle Scholar
Lieberman, I., Abrams, R., Hunt, N. & Ove, P. (1963). J. biol. Chem. 238, 3955.CrossRefGoogle Scholar
Mann, S. O., Fell, B. F. & Dalgarno, A. C. (1974). Res. vet. Sci. 17, 91.CrossRefGoogle Scholar
Mazia, D. (1961). In The Cell, Vol. 3, p. 77 [Brachet, J. and Mirsky, A. E., editors]. New York and London: Academic Press.CrossRefGoogle Scholar
Mills, C. F., Quarterman, J., Williams, R. B., Dalgarno, A. C. & Panic, B. (1967). Biochem. J. 102, 712.CrossRefGoogle Scholar
Morisawa, M. & Mohri, H. (1972). Exp. cell Res. 70, 311.CrossRefGoogle Scholar
Myren, J., Luketic, G. C., Ceballos, R., Sachs, G. & Hirschowitz, B. I. (1966). Am. J. dig. Dis. 11, 394.CrossRefGoogle Scholar
Nickolson, V. J. & Veldstra, H. (1972). FEBS Letters 23, 303.CrossRefGoogle Scholar
Patzelt, C., Singh, A., Le Marchand, Y., Orci, L. & Jeanrenaud, B. (1975). J. Cell Biol. 66, 609.CrossRefGoogle Scholar
Prasad, A. S., Oberleas, D., Wolf, P. & Horwitz, J. P. (1967). J. clin. Invest. 46, 549.CrossRefGoogle Scholar
Reinhold, J. G., Kfoury, G. A. & Thomas, T. A. (1967). J. Nutr. 92, 173.CrossRefGoogle Scholar
Searle, J., Lawson, T. A., Abbot, P. J., Harmon, B. & Kerr, J. F. R. (1975). J. Path. 116, 129.CrossRefGoogle Scholar
Stephan, J. K. & Hsu, J. M. (1973). J. Nutr. 103, 548.CrossRefGoogle Scholar
Swenerton, H., Shrader, R. & Hurley, L. S. (1969). Science, N.Y. 166, 1014.CrossRefGoogle Scholar
Taylor, E. W. (1965). J. Cell Biol. 25, 145.CrossRefGoogle Scholar
Todd, W. R., Elvejhem, C. A. & Hart, E. B. (1934). Am. J. Physiol. 107, 146.CrossRefGoogle Scholar
Wang, D. Y., Greenbaum, A. L. & Harkness, R. D. (1963). Biochem. J. 86, 62.CrossRefGoogle Scholar
Weisenberg, R. C., Borisy, G. G. & Taylor, E. W. (1968). Biochemistry 7, 4466.CrossRefGoogle Scholar
Weser, V., Seeber, S. & Warnecke, P. (1968). Biochim. biophys Acta 179, 422.CrossRefGoogle Scholar
Williams, R. B. (1972). Br. J. Nutr. 27, 121.CrossRefGoogle Scholar
Williams, R. B. & Chesters, J. K. (1970). Br. J. Nutr. 24, 1053.CrossRefGoogle Scholar
Williams, R. B. & Mills, C. F. (1970). Br. J. Nutr. 24, 989.CrossRefGoogle Scholar
Williams, R. B., Mills, C. F., Quaterman, J. & Dalgarno, A. C. (1965). Biochem. J. 95, 29P.Google Scholar
Wyllie, A. R., Kerr, J. F. R. & Currie, A. R. (1973). J. Path. 111, 255.CrossRefGoogle Scholar