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Effects of yoghurt enriched with plant sterols on serum lipids in patients with moderate hypercholesterolaemia

Published online by Cambridge University Press:  09 March 2007

Robert Volpe ,
Leena Niittynen ,
Riitta Korpela ,
Cesare Sirtori ,
Antonello Bucci ,
Nadia Fraone  and
Franco Pazzucconi
Robert Volpe
Affiliation:
Institute of Systematic Medical Theraphy, University of Rome ‘La Sapienza’, Rome, Italy
Leena Niittynen
Affiliation:
Valio Ltd, Research Centre, Po Box 30, FIN-00039 Helsinki, Finland
Riitta Korpela*
Affiliation:
Valio Ltd, Research Centre, Po Box 30, FIN-00039 Helsinki, Finland Foundation for Nutrition Research, Helsinki, Finland
Cesare Sirtori
Affiliation:
Institute of Pharmacologiacal Sciences, University of Milan, Milan, Italy
Antonello Bucci
Affiliation:
Institute of Systematic Medical Theraphy, University of Rome ‘La Sapienza’, Rome, Italy
Nadia Fraone
Affiliation:
Institute of Pharmacologiacal Sciences, University of Milan, Milan, Italy
Franco Pazzucconi
Affiliation:
Institute of Systematic Medical Theraphy, University of Rome ‘La Sapienza’, Rome, Italy
*
*Corresponding author: Dr R. Korpela, fax +358 10381 3019, email [email protected]
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Abstract

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The objective of the present study was to assess the effect of consumption of a yoghurt-based drink enriched with 1–2 g plant sterols/d on serum lipids, transaminases, vitamins and hormone status in patients with primary moderate hypercholesterolaemia. Thirty patients were randomly assigned to one of two treatment groups: a low-fat low-lactose yoghurt-based drink enriched with 1 g plant sterol extracted from soyabean/d v. a low-fat low-lactose yoghurt, for a period of 4 weeks. After a 2-week wash-out period, patients were crossed over for an additional 4-week period. Second, after a 4-week wash-out period, eleven patients were treated with 2 g plant sterols/d in a second open part of the study for a period of 8 weeks. The yoghurt enriched with plant sterols significantly reduced, in a dose-dependent manner, serum total cholesterol and LDL-cholesterol levels and LDL-cholesterol:HDL-cholesterol (P<0·001), whereas no changes were observed in HDL-cholesterol and triacylglycerol levels, either in the first or the second part of the study. There were only slight, not statistically significant, differences in serum transaminase, vitamin and hormone levels. To conclude, a low-fat yoghurt-based drink moderately enriched with plant sterols may lower total cholesterol and LDL-cholesterol effectively in patients with primary moderate hypercholesterolaemia.

Keywords

Plant sterolsHypercholesterolaemiaSex hormonesFat-soluble vitamins
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 2 , August 2001 , pp. 233 - 239
Copyright
Copyright © The Nutrition Society 2001

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