Hostname: page-component-586b7cd67f-tf8b9 Total loading time: 0 Render date: 2024-11-24T01:28:10.487Z Has data issue: false hasContentIssue false
  • English
  • Français

The effects of whole wheat, wheat bran and zinc in the diet on the absorption and accumulation of cadmium in rats

Published online by Cambridge University Press:  09 March 2007

Anncatherine Moberg Wing
Anncatherine Moberg Wing
Affiliation:
The Biophysics Laboratory and the Departments of Nutritional Research and Pathology, University of Umeå, S-901 87 Umeå, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The purpose of the present study was to determine if the inclusion of whole-grain wheat or wheat bran in the diet or the addition of Zn to the diet affects the absorption and accumulation of Cd. Five groups of six rats each were fed deionized water and one of five diets composed of one part basic diet and one part wheat crispbread for 6 weeks. The accumulation of Cd in the liver and kidneys was measured using atomic absorption spectrometry and estimated by measuring the absorption and retention of 109Cd from a single meal after 3 weeks on the diets. The fractional accumulation of Cd in the liver and kidneys was lower in rats fed on whole-wheat and bran diets than in those fed on wheat-endosperm diets. As adding Zn or Cd to endosperm diets to approximate the bran and whole-wheat diet levels had no effect on the fractional Cd absorption, the reduced absorption from the whole-wheat and bran diets is probably not due to their higher Zn and Cd concentrations but may be due to their higher fibre or phytate concentrations. The amount of Cd concentrations.

Keywords

Whole-grain wheatWheat branZincCadmium
Type
Effects of Diet on Trace Element Nutriton
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 199 - 209
Copyright
Copyright © The Nutrition Society 1993

References

REFERENCES

Asp, N.-G., Johansson, C.-G., Hallmer, H. & Siljeström, M. (1983). A rapid enzymatic method for assay of insoluble and soluble dietary fibre. Journal of Agricultural and Food Chemistry 31, 476–482.Google Scholar
De Boland, A. R., Garner, G. B. & O'Dell, B. L. (1975). Identification and properties of ‘phytate’ in cereal grains and oilseed products. Journal of Agricultural and Food Chemistry 23, 1186–1189.CrossRefGoogle ScholarPubMed
Elinder, C.-G. (1985 a). Cadmium: uses, occurrence, and intake. In Cadmium and Health: A Toxicological and Epidemiological Appraisal: Exposure, Dose and Metabolism. vol. 1, pp. 23–63 [ Friberg, L., Elinder, C.-G., Kjellstrom, T. and Nordberg, G., editors]. Boca Raton, Florida: CRC Press.Google Scholar
Elinder, C.-G. (1985 b). Normal values for cadmium in human tissues, blood and urine in different countries. In Cadmium and Health: A Toxicological and Epidemiological Appraisal: Exposure, Dose and Metabolism, vol. 1, pp. 81–102 [ Friberg, L., Elinder, C.-G., Kjellstrom, T. and Nordberg, G., editors]. Boca Raton, Florida: CRC Press.Google Scholar
Ellis, R., Morris, E. R. & Philpot, C. (1977). Quantitative determination of phytate in the presence of high inorganic phosphate. Analytical Biochemistry 77, 536–539.Google Scholar
Engstrom, B. & Nordberg, G. F. (1979). Factors influencing absorption and retention of oral 109Cd in mice: age, pretreatment and subsequent treatment with non-radioactive cadmium. Acta Pharmacologica et Toxicologica 45, 315–324.CrossRefGoogle ScholarPubMed
Flanagan, P. R., McLellan, J. S., Haist, J., Cheran, G., Chamberlain, M. J. & Valberg, L. S. (1978). Increased dietary cadmium absorption in mice and human subjects with iron deficiency. Gastroenterology 74, 841–846.CrossRefGoogle ScholarPubMed
Gartrell, M. J., Crawn, J. C., Podrebdrac, D. S. & Gundersson, E. L. (1986). Pesticides, selected elements, and other chemicals in adult total diet samples, October 1980-March 1982. Journal of the Association of Official Analytical Chemists 69, 160–161.Google ScholarPubMed
Jackl, G. A., Rambeck, W. A. & Kollmer, W. E. (1985). Retention of cadmium in organs of the rat after a single dose of labeled cadmium-3-phytate. Biological Trace Element Research 1, 69–74.CrossRefGoogle Scholar
Jacobs, R. M., Fox, M. R. S., Jones, A. O. L., Hamilton, R. P. & Lener, J. (1977). Cd metabolism: individual effects of Zn, Cu and Mn. Federation Proceedings 36, 1152.Google Scholar
Jorhem, L., Mattsson, P. & Slorach, S. (1984). Lead, cadmium, zinc and certain other metals in foods on the Swedish market. Vår Föda 36, suppl.3.Google Scholar
Kello, D. & Kostial, K. (1977). Influence of age on whole-body retention and distribution of 115mCd in the rat. Environmental Research 14, 92–98.Google Scholar
Kiyozumi, M., Miyata, K., Takahashi, Y., Mizunaga, F., Mishima, M., Noda, S., Nakagawa, M. & Kojima, S. (1982). Studies on poisonous metals. IX. Effects of dietary fibres on absorption of cadmium in rats. Chemical and Pharmaceutical Bulletin 30, 4494–4499.Google Scholar
Kjellstrom, T. (1986). Renal effects. In Cadmium and Health: A Toxicological and Epidemiological Appraisal: Eflects and Response, vol. 2, pp. 98–99 [ Friberg, L., Elinder, C.-G., Kjellstrom, T. and Nordberg, G. F., editors ]. Boca Raton, Florida: CRC Press.Google Scholar
Lamphere, D. N., Dorn, C. R., Reddy, C. S. & Meyer, A. W. (1984). Reduced cadmium body burden in cadmium exposed calves fed supplemental zinc. Environmental Research 33, 119–129.Google Scholar
Lucis, O. J., Lynk, M. E. & Lucis, R. (1969). Turnover of cadmium 109 in rats. Archives of Environmental Health 18, 307–310.CrossRefGoogle ScholarPubMed
Nilsson, J. & Wallgren, B. (1987). Kadmium i miljön – bedijmningsgrunder. Rapport no. 3317, Naturvirdsverket. Solna, Sweden: Modin-tryck.Google Scholar
Nordberg, G. F., Kjellstrom, T. & Nordberg, M. (1985). Kinetics and metabolism. In Cadmium and Health: A Toxicological and Epidemiological Appraisal: Exposure, Dose and Metabolism, vol. 1, pp. 103–172 [ Friberg, L., Elinder, C.-G., Kjellstrom, T. and Nordberg, G., editors]. Boca Raton, Florida: CRC Press.Google Scholar
Omori, M. & Muto, Y. (1977). Effects of dietary protein, calcium, phosphorus and fibre on renal accumulation of exogenous cadmium in young rats. Journal of Nutritional Science and Vitaminology 23, 361–373.CrossRefGoogle ScholarPubMed
Sandberg, A.-S., Hasselblad, C., Hasselblad, K. & Hulttn, L. (1982). The effect of wheat bran on the absorption of minerals in the small intestine. British Journal of Nutrition 48, 185–191.Google Scholar
Snedecor, G. W. & Cochran, W. G. (1980). Statistical Methods, 7th ed. Ames, Iowa: Iowa State University Press.Google Scholar
Vahter, M., Berglund, M., Lind, B., Jorhem, L., Slorach, S. & Friberg, L. (1991). Personal monitoring of lead and cadmium exposure – a Swedish study with special reference to methodological aspects. Scandinavian Journal of Work Environment and Health 11, 65–74.CrossRefGoogle Scholar
Warner, L. G. & Breuer, L. H. Jr. (1972). Nutrient requirements of the laboratory rat. In Nutrient Requirements of Domestic Animals. No 10. Nutrient Requirements of Laboratory Animals, 2nd revised ed. Washington, DC: National Academy of Science.Google Scholar
Welch, W. R., House, W. A. & Van Campen, D. R. (1979). Availability of cadmium from lettuce leaves and cadmium sulfate to rats. Nutritional Reports International 11, 3542.Google Scholar
World Health Organization (1990). Diet, Nutrition, and the Prevention ofchronic Diseases. Technical Report Series no. 797. Geneva: WHO.Google Scholar