Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-11-15T03:26:42.917Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of rye bran, oat bran and soya-bean fibre on bile composition, gallstone formation, gall-bladder morphology and serum cholesterol in Syrian golden hamsters (Mesocricetus auratus)*

Published online by Cambridge University Press:  10 October 2007

Jie-Xian Zhangt ,
Eva Lundin ,
Carl-Olof Reuterving ,
Göran Hallmans ,
Roger Stenling ,
Eric Westerlund  and
Per Åman
Jie-Xian Zhangt
Affiliation:
Departments of Pathology and Nutritional Research. University of Umed, S-901 87 Umeå, Sweden
Eva Lundin
Affiliation:
Departments of Pathology and Nutritional Research. University of Umed, S-901 87 Umeå, Sweden
Carl-Olof Reuterving
Affiliation:
Departments of Pathology and Nutritional Research. University of Umed, S-901 87 Umeå, Sweden
Göran Hallmans
Affiliation:
Departments of Pathology and Nutritional Research. University of Umed, S-901 87 Umeå, Sweden
Roger Stenling
Affiliation:
Departments of Pathology and Nutritional Research. University of Umed, S-901 87 Umeå, Sweden
Eric Westerlund
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
Per Åman
Affiliation:
Department of Food Science, Swedish University of Agricultural Sciences, Uppsala, Sweden
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The effects of rye bran, oat bran and soya-bean fibre on serum lipids, bile composition and gallstone formation were studied in male Syrian golden hamsters (Mesocricetus auratus). The control groups received fibre-free stone-provoking (O1 diet) or non-stone-provoking (O2 diet) diets. The serum cholesterol levels were lower for all groups fed on the diets supplemented with the dietary fibre sources compared with the control groups. The total content of bile acids in bile was higher in groups given ryebran diets compared with the corresponding controls. The proportion of cholic acid was higher and that of chenodeoxycholic and lithocholic acid lower in the groups given rye-bran-, oat-bran- or soya-bean-fibre-supplemented diets, compared with the corresponding controls. The secondary: primary bile acid ratio was lower in the group given the rye-bran-supplemented O1 diet. The lithocholic:deoxycholic acid ratio was lower in the groups given rye-bran-, oat-bran- or soya-bean-fibre-supplemented diets than in the corresponding controls. A lower frequency of gallstones was observed only for the group receiving the rye-bran-supplemented O1 diet while the lithogenic index was lower in the groups given the rye-bran-supplemented O2 diet. A decreased epithelial volume density of the gall-bladder and an increased smooth muscular volume density were observed in animals given oat-bran- and rye-bran-supplemented O1 diets, whereas for the soya-bean-fibre-supplemented O1 diet, only the smooth muscular volume density was increased.

Keywords

Rye branOat branSoya-bean fibreBileSerum lipidsHamsters
Type
Effects of complex carbohydrate foods on lipids
Information
British Journal of Nutrition , Volume 71 , Issue 6 , June 1994 , pp. 861 - 870
Copyright
Copyright © The Nutrition Society 1994

References

Anderson, J. W., Story, L., Sieling, B., Chen, W.-J. L., Petro, M. S. & Story, J. (1984). Hypocholesterolemic effects of oat-bran or bean intake for hypercholesterolemic men. American Journal sf Clinical Nutrition 40, 1146–1155.CrossRefGoogle ScholarPubMed
Asp, N. G., Johansson, C. G., Hallmer, H. & Siljeström, M. (1983). Rapid enzymatic assay of insoluble and soluble dietary fibre. Journal of Agricultural and Food Chemistry 31, 476–482.CrossRefGoogle Scholar
Association of Official Analytical Chemists (1975). Official Methods of Analysis. Washington, DC: AOAC.Google Scholar
Bergman, F. & van der Linden, W. (1975). Effect of dietary fibre on gallstone formation in hamsters. Zeitschrift fur Ernuhrungswissenschuft 14, 218–224.CrossRefGoogle ScholarPubMed
Brydon, W. G., Eastwood, M. A. & Elton, R. A. (1988). The relationship between stool weight and the lithocholate/deoxycholate ratio in faeces. British Journal of Cancer 57, 635–636.CrossRefGoogle ScholarPubMed
Chen, W.-J. L., Anderson, J. W. & Gould, M. R. (1981). Effects of oat bran, oat gum and pectin on lipid metabolism of cholesterol-fed rats. Nutrition Reports International 24, 1093–1098.Google Scholar
Dam, H. & Christensen, F. (1952). Alimentary production of gallstones in hamsters. Acta Pathologicu et Microbiologica Scandinavica 30, 236–242.CrossRefGoogle ScholarPubMed
Davidson, M. H., Dugan, L. D., Burns, J. H., Bova, J., Story, K. & Drennan, K. B. (1991). The hypocholesterolemic effect of β-glucan in oatmeal and oat bran. A dose controlled study. Journal of the American Medical Association 265, 1833–1839.CrossRefGoogle Scholar
Furda, I. (1990). Interaction of dietary fiber with lipids mechanistic theories and their limitations. Advances in E.uperimentci1 Medicine and Biology 270, 67–82.CrossRefGoogle ScholarPubMed
Gurantz, D., Laker, M. F. & Hofmann, A. F. (1981). Enzymatic measurement of choline-containing phospholipids in bile. Journal qf Lipid Research 22, 373–376.CrossRefGoogle ScholarPubMed
Hill, M. J., Drasar, B. S., Aries, V. C., Crowther, J. S., Hawksworth, G. B. & Williams, R. E. O. (1971). Bacteria and aetiology of cancer of the large bowel. Lancet i, 95–100.CrossRefGoogle Scholar
Kritchevsky, D., Tepper, S. A. & Klurfeld, D. M. (1984). Effect of pectin and cellulose on formation and regression of gallstones in hamsters. Experientia 40, 350–351.CrossRefGoogle ScholarPubMed
Lo, G. S., Goldberg, A. P., Lim, A., Grundhauser, J. J., Anderson, C. & Schonfeld, G. (1986). Soy fiber improves lipid and carbohydrate metabolism in primary hyperlipidemic subjects. Atherosclerosis 62, 239–248.CrossRefGoogle ScholarPubMed
Nair, P. P. (1988). Role of bile acids and neutral sterols in carcinogenesis. American Journal of Clinical Nurririon 48, 768–774.CrossRefGoogle ScholarPubMed
Owen, R. W., Henly, P. J., Thompson, M. H. & Hill, M. J. (1986). Steroids and cancer: faecal bile acid screening for early detection of cancer risk. Journal of Steroid Biochemistry 24, 391–394.CrossRefGoogle ScholarPubMed
Owen, R. W., Dodo, M., Thompson, M. H. & Hill, M. J. (1987). Fecal steroids and colorectal cancer. Nutrition and Cancer 9, 70–80.CrossRefGoogle ScholarPubMed
Petterson, D. & Åman, P. (1987). The variation in chemical composition of triticales grown in Sweden. Acta Agriculturae Scandinavica 37, 20–26.CrossRefGoogle Scholar
Qureshi, M. Y., Murphy, G. M. & Dowling, R. H. (1980). The enzymatic determination of total phospholipids in bile and bile-rich duodenal aspirates. Clinicu Chimica Acta 105, 407–410.CrossRefGoogle ScholarPubMed
Rotstein, O. D., Key, R. M., Wayman, M. & Strasberg, S. M. (1981). Prevention of cholesterol gallstone by lignin and lactulose in the hamster. Gastroenterology 81, 1098–1103.CrossRefGoogle ScholarPubMed
Sasaki, J., Funakoshi, M. & Arakawa, K. (1985). Effect of soybean crude fiber on the concentrations of serum lipids and apolipoproteins in hyperlipemic subjects. Annals of Nutrition and Metabolism 29, 274–278.CrossRefGoogle ScholarPubMed
Thomas, P. J. & Hofmann, A. F. (1973). A simple calculation of the lithogenic index of bile: expressing biliary lipid composition on rectangular coordinates. Gastroenrerology 65, 698–699.CrossRefGoogle ScholarPubMed
Turjman, N., Goodman, G., Jaeger, B. & Nair, P. P. (1984). Diet, nutrition intake, and metabolism in populations at high and low risk for colon cancer. Metabolism of bile acids. American Journal of Clinical Nutririon 40, 937–941.CrossRefGoogle ScholarPubMed
Van Horn, L. V., Liu, K., Parker, D., Emidy, L., Liao, Y., Pan, W. H., Giumetti, D., Hewitt, J. & Stamler, J. (1986). Serum lipid response to oat product intake with fat-modified diet. Journal of the American Dietetic Association 86, 759–764.CrossRefGoogle ScholarPubMed
Wahlin, T. (1976). Effects of lithogenic diets on mouse gallbladder epithelium. A histochemical, cytochemical and morphometric study. Virchows Archiv. B. Zellpathologie 22, 273–286.CrossRefGoogle ScholarPubMed
Weibel, E. R., Staubli, W., Gnagi, H. R. & Hess, F. A. (1969). Correlated morphometric and biochemical studies on the liver cell. L. Morphometric model, stereologic methods, and normal morphometric data for rat liver. Journal of Cell Biology 42, 68–91.CrossRefGoogle Scholar
Zhang, J. X., Bergman, F., Hallmans, G., Johansson, G., Lundin, E., Stenling, R., Theander, O. & Westerlund, E. (1990). The influence of barley fibre on bile composition, gallstone formation, serum cholesterol and intestinal morphology in hamsters. Acta Patbologicu Microbiologicu et Immunologica Scandinavica 98, 568–574.CrossRefGoogle ScholarPubMed
Zhang, J. X., Hallmans, G., Adlercreutz, H., Åman, P., Westerlund, E., Lundin, E. & Stenling, R. (1993). Effect of oat and rye fractions on biliary and faecal bile acid profiles in Syrian golden hamsters (Mesocricetus auratus). British Journal of Nutrition 10, 525–536.CrossRefGoogle Scholar
Zhang, J. X., Lundin, E., Hallmans, G., Bergman, F., Westerlund, E. & Petterson, P. (1992). Dietary effect of barley fibre, wheat bran and rye bran on bile composition and gallstone formation in hamsters. Acta Pathologica Microhiologicu et Immunologica Scandinavica 100, 553–551.CrossRefGoogle ScholarPubMed