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Effects of energy restriction and fish oil supplementation on renal guanidino levels and antioxidant defences in aged lupus-prone B/W mice

Published online by Cambridge University Press:  08 March 2007

You Jung Kim ,
Takako Yokozawa  and
Hae Young Chung
You Jung Kim
Affiliation:
Department of Cosmetology, Pusan Women's College, Pusanjin-Gu, Pusan, Korea
Takako Yokozawa
Affiliation:
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan
Hae Young Chung*
Affiliation:
Department of Pharmacy, Longevity Life Science and Technology Institutes, Aging Tissue Bank, Pusan National University, Kumjeong-Gu, Pusan, Korea
*
*Corresponding author: Dr Hae Young Chung, fax +82 51 510 2821, email [email protected]
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Abstract

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Energy restriction (ER) and dietary fish oil (FO) are known to reduce the severity of glomerulonephritis and increase the lifespan of lupus-prone (NZB×NZW) F1 (B/W) mice. In the present study, mice were fed either ad libitum or energy-restricted (a 40 % lower energy intake than the diet ad libitum), semi-purified diets containing 5 % maize oil or 5 % fish oil supplementation. To estimate the renal damage associated with oxidative stress, the total amounts of reactive oxygen species (ROS), cyclooxygenase-derived ROS and levels of guanidino compounds were measured. Additionally, we assessed the putative action of ER and FO on several key antioxidant enzymes measured in the kidney post-mitochondrial fraction. Results showed that the age-related increase in creatinine level was significantly reduced by ER and FO in old mice. In contrast, arginine and guanidino acetic acid levels showed a decrease with age but were increased by ER and FO. The GSH:GSSG ratio showed a significant decrease with age, whereas ER and FO feeding prevented the decrease. The age-related decrease in antioxidant scavenging superoxide dismutase, catalase and glutathione peroxidase activities were all reversed by ER and FO. The moderately decreased glutathione reductase and glutathione-S-transferase activities with age were significantly increased by ER and FO. Furthermore, the increased total ROS and cyclooxygenase-derived ROS levels were effectively reduced by ER and FO. In conclusion, our data strongly indicate that ER and FO maintain antioxidant status and GSH:GSSG ratio, thereby protecting against renal deterioration from oxidative insults during ageing.

Keywords

Energy restrictionDietary fish oilGSH:GSSG ratioGuanidino compoundsAntioxidant enzymesOxidative stress
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 6 , June 2005 , pp. 835 - 844
Copyright
Copyright © The Nutrition Society 2005

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