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Effects of dietary protein on renal function and lipid metabolism in five-sixths nephrectomized rats

Published online by Cambridge University Press:  01 August 2008

Shu-Tzu Chen ,
Sheng-Jeng Peng  and
Jiun-Rong Chen
Shu-Tzu Chen
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
Sheng-Jeng Peng
Affiliation:
Division of Nephrology, Cathay General Hospital, Taipei 110, Taiwan
Jiun-Rong Chen*
Affiliation:
Department of Nutrition and Health Sciences, Taipei Medical University, Taipei 110, Taiwan
*
*Corresponding author: Dr Jiun-Rong Chen, fax +886 2 2737 3112, email [email protected]
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Abstract

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The objective of the present experiment was to examine the effect of substituting different quantities of soyabean protein for casein on renal function and lipid metabolism in rats with chronic renal failure induced by a five-sixths nephrectomy. Experimental animals were subjected to a nephrectomy and fed either casein or soyabean protein (200 or 100 g/kg diet). The diets were isoenergetic with identical fat, Na, K and P contents. Rats ingesting 200 g casein/kg diet showed a significantly (P<0·05) accelerated course of chronic renal failure, while the soyabean-protein groups showed retarded progression of the experimentally induced renal disease and hypercholesterolaemic effects. Rats in the low-soyabean-protein diet (100 g/kg) also demonstrated increased serum albumin and decreased serum triacylglycerol, total cholesterol concentrations and blood urea-N; however, the low-casein diet significantly (P<0·05) increased serum triacylglycerol. Results of the present study show that the replacement of casein by soyabean protein was related to the rate of progression of renal failure and improvement in lipid profiles in serum of five-sixths nephrectomized rats.

Keywords

Soyabean proteinNephrectomyChronic renal failureProgressionPlasma lipid
Type
Research Article
Information
British Journal of Nutrition , Volume 89 , Issue 4 , April 2003 , pp. 491 - 497
Copyright
Copyright © The Nutrition Society 2003

References

Allain, CC, Poon, LS, Chan, CS, Richmond, W & Fu, PC (1974) Enzymatic determination of total serum cholesterol. Clinical Chemistry 20, 470–475.CrossRefGoogle ScholarPubMed
Appel, GB (1991) Nephrology Forum: lipid abnormalities in renal disease. Kidney International 39, 169–183.CrossRefGoogle Scholar
Anderson, JW, Johnstone, BM & Cook-Newell, ME (1995) Meta-analysis of effects of soy protein on serum lipids in humans. New England Journal of Medicine 333, 276–282.CrossRefGoogle Scholar
Anderson, JW, Smith, BM & Washnock, CS (1999) Cardiovascular and renal benefits of dry bean and soybean intake. American Journal of Clinical Nutrition 70, 464–474.CrossRefGoogle ScholarPubMed
Atluru, S & Atluru, D (1991) Evidence that genistein, a protein-tyrosine kinase inhibitor, inhibits CD 28 monoclonal-antibody-stimulated human T cell proliferation. Transplant 51, 448–450.CrossRefGoogle Scholar
Barth, CA & Pfeuffer, M (1988) Dietary protein and atherogenesis. Klinische Wochenschrift 66, 135–143.CrossRefGoogle ScholarPubMed
Brenner, M, Meyer, TW & Hostetter, TH (1982) Dietary protein intake and the progressive nature of kidney disease. New England Journal of Medicine 307, 652–659.Google ScholarPubMed
Chan, JCM (1974) The influence of dietary intake on endogenous acid production. Nutrition and Metabolism 16, 1–9.CrossRefGoogle ScholarPubMed
Carroll, KK (1978) Dietary protein in relation to plasma cholesterol levels and atherosclerosis. Nutrition Reviews 36, 1–5.CrossRefGoogle ScholarPubMed
Doumas, BT, Warson, WA & Biggs, HG (1971) Albumin standards and the measurement of serum albumin with bromcresol green. Clinica Chimica Acta 31, 87–96.CrossRefGoogle ScholarPubMed
Drouliscos, NJ & Bowland, JP (1969) Biological evaluation of rapeseed meal, soyabean meal and casein fed to the wealing and the mature rat. British Journal of Nutrition 23, 113–123.CrossRefGoogle Scholar
Fabiny, DL & Ertingshausen, G (1971) Automated reaction-rate method for determination of serum creatinine with the CentrifiChem. Clinical Chemistry 17, 696–700.CrossRefGoogle ScholarPubMed
Food and Drug Administration (1991) Department of Health claims for food. Federal Register 56, 60537–60566.Google Scholar
Forsythe, WA (1990) Dietary protein, cholesterol and thyroxine: a proposed mechanism. Journal of Nutrition 36, 101–104.Google ScholarPubMed
Forsythe, WA (1995) Soy protein, thyroid regulation and cholesterol metabolism. Journal of Nutrition 125, 619–623.Google ScholarPubMed
Huang, YS, Koba, K, Horrobin, DF & Sugano, M (1993) Interrelationship between dietary protein, cholesterol and n-6 polyunsaturated fatty acid metabolism. Progress in Lipid Research 32, 123–137.CrossRefGoogle ScholarPubMed
Huff, MW & Carroll, KK (1980) Effects of dietary protein on turnover, oxidation, and absorption of cholesterol, and on steroid excretion in rabbits. Lipid Research 21, 546–558.CrossRefGoogle ScholarPubMed
Iritani, N, Hosomi, H, Fukuda, H, Tada, K & Ikeda, H (1996) Soybean protein suppresses hepatic lipogenic enzyme gene expression in Wistar fatty rats. Journal of Nutrition 126, 380–388.CrossRefGoogle ScholarPubMed
Iritani, N, Nagashima, K, Fukuda, H, Katsurada, A & Tanaka, T (1986) Effects of dietary protein on lipogenic enzymes in rat liver. Journal of Nutrition 116, 190–197.CrossRefGoogle ScholarPubMed
Ihle, BU, Becker, GJ, Whitworth, JA, Charlwood, RA & Kincaid-Smith, PS (1989) The effect of protein restriction on the progression of renal insufficiency. New England Journal of Medicine 321, 1773–1777.CrossRefGoogle ScholarPubMed
Kaltwasser, H & Schlegel, HG (1966) NADH-dependent coupled enzyme assay for urease and other ammonia-producing systems. Analytical Biochemistry 16, 132–138.CrossRefGoogle ScholarPubMed
Kaysen, GA & Kopple, J (1983) Dietary tryptophan supplement prevents proteinuria in the seven-eighths nephrectomized rat. Kidney International 23, 473–479.CrossRefGoogle ScholarPubMed
Kenner, GH, Evan, AP, Blomgren, P, Aronoff, GR & Luft, FC (1985) Effect of protein intake on renal function and structure in partially nephrectomised rats. Kidney International 27, 739–750.CrossRefGoogle Scholar
Kinoshita, E, Yamakoshi, J & Kikuchi, M (1993) ACE inhibitor in soy sauce. Journal of Biochemistry 57, 1107–1110.Google ScholarPubMed
Kontessis, PS, Bossinakou, I, Sarika, L, Aliopoulou, E, Papantonou, A, Trevisan, R, Roussi, D, Stipsanelli, K & Grigorakis, S (1995) Renal metabolic and hormonal responses to protein of different origin in normotensive nonproteinuric type I diabetic patients. Diabetes Care 18, 1233–1240.CrossRefGoogle ScholarPubMed
Kontessis, P, Jones, S, Trevisan, R, Nosadini, R, Fioretto, P, Borsato, M, Sacerdoti, D & Di Viberti, GC (1990) Renal metabolic and hormonal responses to ingestion of animal and vegetable protein. Kidney International 38, 136–144.CrossRefGoogle Scholar
Kurowaka, EM & Carroll, KK (1990) Essential amino acids in relation to hypercholesterolemia induced in rabbits by dietary casein. Journal of Nutrition 120, 831–836.CrossRefGoogle Scholar
Lovati, MR, Manzoni, C, Corsini, A, Frattini, R, Fumagalli, R & Sirtori, CR (1992) Low density lipoprotein receptor activity is modulated by soybean globulins in cell culture. Journal of Nutrition 122, 1971–1978.CrossRefGoogle ScholarPubMed
Lowry, DH, Rosebrough, NL, Farr, A & Randall, RJ (1951) Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 193, 265–275.CrossRefGoogle ScholarPubMed
Pecis, M, Azevedo, M & Gross, JL (1994) Chicken and fish diet reduces glomerular hyperfiltration in IDDM patient. Diabetes Care 17, 665–672.CrossRefGoogle Scholar
Remer, T & Manz, F (1994) Estimation of the renal net acid excretion by adults consuming diets containing variable amounts of protein. American Journal of Clinical Nutrition 59, 1356–1361.CrossRefGoogle ScholarPubMed
Sanchez, A & Hubbard, RW (1991) Plasma amino acids and the insulin/glucagon ratio as an explanation for the dietary protein modulation of atherosclerosis. Medical Hypotheses 35, 324–329.CrossRefGoogle ScholarPubMed
Sirtori, CR, Adrad, E, Conti, F, Mantero, O & Gatt, E (1977) Soybean protein diet in the treatment of Type II hyperlipoproteinemia. Lancet 1, 275–277.CrossRefGoogle Scholar
Soldin, SJ, Henderson, L & Hill, JG (1978) The effect of bilirubin and ketones on reaction rate methods for the measurement of creatinine. Clinical Biochemistry 11, 82–86.CrossRefGoogle ScholarPubMed
Soroka, N, Silverberg, DS, Greemland, M, Birk, Y, Blum, M, Peer, G & Ianina, A (1998) Comparison of a vegetable-based (soya) and an animal-based low-protein diet in predialysis chronic renal failure patients. Nephron 79, 173–180.CrossRefGoogle Scholar
Spayd, RW, Bruschi, B, Burdick, BA, Dappen, GM, Eikenberry, JN, Esders, TW, Figueras, J, Goodhue, CT, LaRossa, DD, Nelson, RW, Rand, RN & Wu, TW (1978) Multilayer film elements for clinical analysis: application to representative chemical determination. Clinical Chemistry 24, 1343–1350.CrossRefGoogle Scholar
Stenvinkel, P, Heimburger, O, Lindholm, B, Kaysen, GA & Bergstrom, J (2000) Are there two types of malnutrition in chronic renal failure? Evidence for relationships between malnutrition, inflammation and atherosclerosis (MIA syndrome). Nephrology Dialysis Transplantation 15, 953–960.CrossRefGoogle ScholarPubMed
Sugano, M & Koba, K (1993) Dietary protein and lipid metabolism: a multifunctional effect. Annals of the New York Academy of Sciences 676, 215–222.CrossRefGoogle ScholarPubMed
Terpstra, AHM, Harkes, L & van der Veen, FH (1981) The effect of different proportions of casein in semipurified diets on the concentration of serum cholesterol and lipoprotein composition in rabbits. Lipid 16, 114–119.CrossRefGoogle ScholarPubMed
Vahouny, GV, Adamson, I & Chalcarz, W (1985) Effects of casein and soy protein on hepatic and serum lipid and lipoprotein lipid distribution in the rat. Atherosclerosis 56, 127–137.CrossRefGoogle ScholarPubMed
Williams, AJ, Baker, F & Walls, J (1987) Effect of varying quantity and quality of dietary protein intake in experimental renal disease in rat. Nephron 46, 83–90.CrossRefGoogle Scholar
Woods, LL (1993) Mechanisms of renal hemodynamic regulation in response to protein feeding. Kidney International 44, 659–675.CrossRefGoogle ScholarPubMed
Young, VR (1991) Soy protein in relation to human protein and amino acid nutrition. Journal of the American Dietetic Association 91, 828–835.CrossRefGoogle ScholarPubMed