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Effects of dietary oleic-rich oils (virgin olive and high-oleic-acid sunflower) on vascular reactivity in Wistar-Kyoto and spontaneously hypertensive rats

Published online by Cambridge University Press:  09 March 2007

M. D. Herrera ,
C. Péerez-Guerrero ,
E. Marhuenda  and
V. Ruiz-Gutiéerrez
M. D. Herrera
Affiliation:
Departamento de Farmacologíia, Facultad de Farmacia, C/Profesor García González s/n, 41012 Sevilla, Spain
C. Péerez-Guerrero
Affiliation:
Departamento de Farmacologíia, Facultad de Farmacia, C/Profesor García González s/n, 41012 Sevilla, Spain
E. Marhuenda
Affiliation:
Departamento de Farmacologíia, Facultad de Farmacia, C/Profesor García González s/n, 41012 Sevilla, Spain
V. Ruiz-Gutiéerrez*
Affiliation:
Instituto de la Grasa (CSIC), Avda, Padre García Tejero no. 4, 41012 Sevilla, Spain
*
Corresponding author: Dr Ruiz-Gutiérrez, fax +34 954 616790, email [email protected]
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Abstract

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The effects of two monounsaturated fatty acid (MUFA)-rich diets, containing virgin olive oil (OO) and high-oleic-acid sunflower oil (HOSO), on development of vascular response from isolated thoracic rat aorta and lipid composition and fatty acid composition were studied and compared with samples from rats fed on a control diet. Dietary MUFA oils were fed for 6 weeks to spontaneously hypertensive (SHR) and Wistar–Kyoto (WKY) rats from 4 weeks of age. The maximum contraction of aortic ring preparations in response to phenylephrine (10-6 M) WAS SIGNIFICANTLY DECREASED IN SHR RATS FED WITH OO (0·81 (sem 0·05) v. 1·18 (sem 0·09) g, P<0·01) and treatment with HOSO did not alter the phenylephrine-induced contractions. The relaxant responses to acetylcholine (10-5 m) were significantly enhanced (30·03 (sem 0·70) v. 18·47 (sem 0·28) %, P<0·001) in the rings from SHR rats treated with OO, and were more pronounced than in WKY rats (P<0·05). In the same way, OO attenuated the dose–response curves induced by phenylephrine (10-8–10-5 m) from SHR rats, accompained with a slower contraction. These results suggest that only the chronic feeding of OO diet was able to attenuate the vascular response of rat aorta. In addition, an increase in phospholipid content (186·7 (sd 3·2) v. 159·1 (sd 11·3) g/kg, P<0·01) and changes in the fatty acid composition of aorta (mainly a decrease in arachidonic acid) could contribute to improving endothelial function. Therefore, the effects can not be attributed exclusively to the content of MUFA (mainly oleic acid). Other components of OO, such as polyphenols, not present in HOSO, may help to explain the vascular protective effect of OO consumption.

Keywords

Olive oilHigh-oleic-acid sunflower oilVascular reactivityRat aorta
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 3 , September 2001 , pp. 349 - 357
Copyright
Copyright © The Nutrition Society 2001

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