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Effects of dietary n-3 polyunsaturated fatty acids from plant and marine origin on platelet aggregation in healthy elderly subjects

Published online by Cambridge University Press:  09 March 2007

A. G. C. L Wensing ,
R. P. Mensink  and
G. Hornstra
A. G. C. L Wensing
Affiliation:
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
R. P. Mensink*
Affiliation:
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
G. Hornstra
Affiliation:
Department of Human Biology, Maastricht University, PO Box 616, 6200 MD Maastricht, The Netherlands
*
*Corresponding author: Dr Ronald Mensink, fax +31 43 367 0976, email [email protected]
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Abstract

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In the present intervention study we compared the effects of α-linolenic acid with those of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on platelet aggregation in vitro and ex vivo in healthy non-institutionalized elderly subjects. We also compared the effects of α-linolenic acid on platelet aggregation in elderly subjects with those in younger volunteers. During a run-in period of 3 weeks all subjects (thirty-eight elderly (> 60 years) and twelve younger volunteers (< 35 years)) received a diet rich in oleic acid. For the next 6 weeks the elderly subjects received a diet rich in oleic acid (n 11), α-linolenic acid (n 14) (6·8 g/d) or EPA/DHA (n 13) (1·05 g EPA plus 0·55 g DHA). The younger subjects were given a diet rich in α-linolenic acid. The diets did not affect ADP- or collagen-induced platelet aggregation in vitro in either platelet-rich plasma or whole blood. The ex vivo platelet aggregation as measured with filtragometry was significantly decreased in the elderly group that received EPA/DHA compared with the α-linolenic acid (P = 0·006) and the oleic acid (P = 0·005) diet groups. Effects of α-linolenic acid were not age-dependent. Our results suggest that α-linolenic acid and EPA/DHA do not change in vitro platelet aggregation. Compared with oleic acid, EPA/DHA, but not α-linolenic acid, favourably affects ex vivo platelet aggregation in healthy elderly subjects.

Keywords

α-Linolenic acidEicosapentaenoic acidDocosahexaenoic acidPlatelet aggregation
Type
Research Article
Information
British Journal of Nutrition , Volume 82 , Issue 3 , September 1999 , pp. 183 - 191
Copyright
Copyright © The Nutrition Society 1999

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