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Effects of conjugated linoleic acid on linoleic and linolenic acid metabolism in man

Published online by Cambridge University Press:  08 March 2007

Anu M. Turpeinen ,
Sonja Bärlund ,
Riitta Freese ,
Peter Lawrence  and
Thomas Brenna
Anu M. Turpeinen*
Affiliation:
Department of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, PO Box 66, 00014 University of Helsink, Finland
Sonja Bärlund
Affiliation:
Department of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, PO Box 66, 00014 University of Helsink, Finland
Riitta Freese
Affiliation:
Department of Applied Chemistry and Microbiology (Nutrition), University of Helsinki, PO Box 66, 00014 University of Helsink, Finland
Peter Lawrence
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
Thomas Brenna
Affiliation:
Division of Nutritional Sciences, Cornell University, Ithaca, NY, USA
*
*Corresponding author: Dr Anu Turpeinen, fax +358 9 19158269, email [email protected]
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Abstract

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Evidence from animal studies suggests that conjugated linoleic acid (CLA) modulates plasma and tissue appearance of newly synthesized PUFA. The effects of a 1·2g (0·5% energy) daily intake of the cis-9, trans-11 (c9, t11) isomer of CLA, trans-10,cis-12 (t10, c12) isomer of CLA or olive oil (placebo) on linoleic acid (LA) and linolenic acid (LNA) metabolism in healthy human volunteers was investigated. Fifteen subjects were fed an experimental diet and supplemented with c9,t11-CLA, t10, c12-CLA or placebo for 7d before consuming a tracer dose of U-[13C]La (50%Mg) And U-[13C]Lna (50Mg). Blood Samples Were Taken At 0, 2, 4, 6, 8, 24, 48, 72 and 168%h and analysed using high-precision MS. No differences between the groups in peak plasma [13C]LA (10·3–11·6% of dose), [13C]LNA (2·5–2·9% of dose), [13C]arachidonic acid (0·09–0·12% of dose), [13C]EPA (0·04–0·06% of dose) or [13C]Dha (0c·06–0·10% of dose) were detected. Concentration V. time curves (area under the curve) also showed no significant differences between groups. This suggests that, in healthy human subjects consuming a diet with adequate intake of essential fatty acids, CLA does not affect metabolism of LA or LNA

Keywords

Conjugated linoleic acidLinoleic acidLinolenic acidStable isotopeMan
Type
Research Article
Information
British Journal of Nutrition , Volume 95 , Issue 4 , April 2006 , pp. 727 - 733
Copyright
Copyright © The Nutrition Society 2006

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