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Effects of aliphatic dioic acids and glycerol-1,2,3-tris(dodecanedioate) on D-glucose-stimulated insulin release in rat pancreatic islets

Published online by Cambridge University Press:  09 March 2007

W. J. Malaisse ,
A. V. Greco  and
G. Mingrone
W. J. Malaisse*
Affiliation:
Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium
A. V. Greco
Affiliation:
Instituto de Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
G. Mingrone
Affiliation:
Instituto de Clinica Medica, Universita Cattolica del Sacro Cuore, Rome, Italy
*
*Corresponding author: Professor W. J. Malaisse, fax +32 2 555 62 39, email [email protected]
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Abstract

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Aliphatic dioic acids have been proposed as alternative nutrients in selected clinical situations. In this study, their possible insulinotropic action was investigated in isolated rat pancreatic islets prepared from fed rats. Azelaic acid, sebacic acid and tridecanedioic acids, when tested at a 10·0 mM CONCENTRATION, WERE FOUND TO AUGMENT INSULIN RELEASE EVOKED BY d-glucose (7·0 mm) in the pancreatic islets. Likewise, glycerol-1,2,3-tris(dodecanoedioate), when used at concentrations close to 1·0 mm, increased the secretory response to the hexose. It is speculated that these findings may extend to insulin-producing cells, the knowledge that aliphatic dioic acids or their esters may act as energy substrates, e.g. in parenteral nutrition.

Keywords

Pancreatic isletsInsulin secretionAliphatic dioic acids
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 733 - 736
Copyright
Copyright © The Nutrition Society 2000

References

Bertuzzi, A, Gandolfi, A, Salinari, S, Mingrone, G, Arcieri-Mastromattei, E, Finotti, E and Greco, AV (1991) Pharmacokinetic analysis of azelaic acid disodium salt: a proposed substrate for total parenteral nutrition. Clinical Pharmacokinetics 20, 411–419.CrossRefGoogle ScholarPubMed
Campillo, JE, Luyckx, AS, Torres, MD and Lefebvre, PJ (1979) Effect of oleic acid on insulin secretion by the isolated perfused rat pancreas. Diabetologia 16, 267–273.CrossRefGoogle ScholarPubMed
De Gaetano, A, Mingrone, G, Castagneto, M, Benedetti, G, Greco, AV and Gasbarrini, G (1999) Kinetics of dodecanedioic acid triglyceride in rats. American Journal of Physiology 276, E497–E502.Google ScholarPubMed
Greco, AV and Mingrone, G (1995) Dicarboxylic acids, an alternate fuel substrate in parenteral nutrition: an update. Clinical Nutrition 14, 143–148.CrossRefGoogle Scholar
Greenough, WB, Crespin, SR and Steinberg, D (1967) Hypoglycemia and hyperinsulinemia in response to raised free fatty acid levels. Lancet ii, 1334–1336.CrossRefGoogle Scholar
Ladrière, L, Björkling, F and Malaisse, WJ (1999) Assessment of the nutritional value of glycerol-1,2,3-tris(methylsuccinate) in fed and starved rats. Molecular Genetics and Metabolism 3, 254–260.CrossRefGoogle Scholar
McGarry, JD and Dobbins, RL (1999) Fatty acids, lipotoxicity and insulin secretion. Diabetologia 42, 128–138.CrossRefGoogle ScholarPubMed
Malaisse, WJ (1999) Insulinotropic action of monosaccharide esters: therapeutic perspectives. Diabetologia 42, 286–291.CrossRefGoogle ScholarPubMed
Malaisse, WJ and Malaisse-Lagae, F (1968) Stimulation of insulin secretion by non-carbohydrate metabolites. Journal of Laboratory and Clinical Medicine 72, 438–448.Google Scholar
Malaisse, WJ, Rasschaert, J, Villanueva-Peñacarrillo, MM and Valverde, I (1993) Respiratory, ionic and functional effects of succinate esters in pancreatic islets. American Journal of Physiology 264, E428–E433.Google ScholarPubMed
Malaisse-Lagae, F, Malaisse, WJ (1984) Insulin release by pancreatic islets. In Methods in Diabetes Research 147–152 [Larner, J and Phol, SL, edtitor]. Ney York, NY: Wiley.Google Scholar
Mingrone, G, De Gaetano, A, Greco, AV, Benedetti, G, Capristo, E, Castagneto, M and Gasbarrini, G (1996) Plasma clearance and oxidation of dodecanedioic acid in humans. Journal of Parenteral and Enteral Nutrition 20, 38–42.CrossRefGoogle ScholarPubMed
Mingrone, G, De Gaetano, A, Greco, AV, Capristo, E, Benedetti, G, Castagneto, M and Gasbarrini, G (1997) Dodecanedioic acid infusion induces a sparing effect on whole body glucose uptake, mainly in non-insulin-dependent diabetes mellitus. British Journal of Nutrition 78, 723–735.CrossRefGoogle ScholarPubMed
Mingrone, G, Tacchino, RM, Castagneto, M, Finotti, E and Greco, AV (1992) Use of even-numbered carbon atom dicarboxylic salts in parenteral nutrition as fuel substrate. Journal of Parenteral and Enteral Nutrition 16, 32–38.CrossRefGoogle ScholarPubMed
Mingrone, G, Tacchino, RM, Greco, AV, Arcieri-Mastromattei, E, Marino, F and Castagneto, M (1989) Preliminary studies of a dicarboxylic acid as an energy substrate in man. Journal of Parenteral and Enteral Nutrition 13, 299–305.CrossRefGoogle ScholarPubMed
Raguso, C, Mingrone, G, Greco, AV, Tataranni, PA, De Gaetano, A and Castagneto, M (1994) Dicarboxylic acids and glucose utilization in humans: effect of sebacate. Journal of Parenteral and Enteral Nutrition 18, 9–13.CrossRefGoogle ScholarPubMed
Ruderman, NB, Saha, AK, Vavvas, D and Witters, LA (1999) Malonyl-CoA, fuel sensing, and insulin resistance. American Journal of Physiology 276, E1–E18.Google ScholarPubMed
Tacchino, RM, Mingrone, G, Marino, F, Arcieri-Mastromattei, E and Greco, AV (1990) Short term infusion of azelaic acid versus intralipid in healthy subjects evaluated by indirect calorimetry. Journal of Parenteral and Enteral Nutrition 14, 169–175.CrossRefGoogle Scholar
Wright, PH, Malaisse, WJ and Reynolds, IJ (1967) The assay of partially neutralized guinea-pig anti-insulin serum. Endocrinology 81, 226–234.CrossRefGoogle ScholarPubMed