Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-07T23:08:10.820Z Has data issue: false hasContentIssue false
  • English
  • Français

Effects of a low-energy diet associated with egg supplementation on plasma cholesterol and lipoprotein levels in normal subjects: results of a cross-over study

Published online by Cambridge University Press:  09 March 2007

Christiane R. Lacombe ,
Geneviève R. Corraze ,
Maryse M. Nibbelink ,
Danièle Boulze ,
Philippe Douste-Blazy  and
Rita Camare
Christiane R. Lacombe
Affiliation:
UA 644 CNRS, Université Paul Sabatier, Institut de Physiologie, Toulouse, France
Geneviève R. Corraze
Affiliation:
UA 644 CNRS, Université Paul Sabatier, Institut de Physiologie, Toulouse, France
Maryse M. Nibbelink
Affiliation:
UA 644 CNRS, Université Paul Sabatier, Institut de Physiologie, Toulouse, France
Danièle Boulze
Affiliation:
Ecole de Diétéique, Toulouse, France
Philippe Douste-Blazy
Affiliation:
INSERM U 101, Université Paul Sabatier, CHU Purpan, Toulouse, France
Rita Camare
Affiliation:
INSERM U 101, Université Paul Sabatier, CHU Purpan, Toulouse, France
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. The influence of a low-energy diet when associated with high-cholesterol intake was investigated in seventeen normal men during an 8-week cross-over study. The subjects were given a daily supplement of two whole eggs and two egg yolks (approximately 1 g cholesterol) either with their usual diet for 4 weeks or with a low-energy diet for 4 weeks. Each subject took part randomly in both dietary periods.

2. During the first part of the study, no changes occurred in the plasma cholesterol of the subjects with egg supplementation of the usual diet.

3. In contrast, the low-energy diet and associated weight loss markedly decreased the tolerance to high- cholesterol intake resulting in increased plasma cholesterol. The mean rise was 22.7% but with wide individual variations in the response. This was almost completely normalized when the subjects returned to their usual energy intake indicating the involvement of weight reduction in the increase observed.

4. Changes in low-density-lipoprotein (LDL) cholesterol were parallel to those of total plasma cholesterol with an increase following the low-energy diet and normalization after body-weight recovery.

5. The opposite effect was shown with the low-energy diet after previous adaptation to the consumption of four eggs per day. This dietary regimen resulted in a decrease in plasma cholesterol although it was not significant. Moreover, the lipoprotein profile was improved with a decrease in very-low-density-lipoprotein (VLDL) cholesterol and an increase in high-density-lipoprotein (HDL) cholesterol.

6. High-cholesterol intake induced significant changes in lipoprotein composition whatever the energy ration. LDL and HDL were enriched in cholesterol esters as early as the 1st month of egg supplementation of the diet.

7. Taken together, the results emphasize the possible adverse effect of slimming diets when associated with high-cholesterol intake. The existence of ‘high-responders’ to these dietary conditions calls for special attention to be paid to the cholesterol content of restricted diets.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 3 , November 1986 , pp. 561 - 575
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Applebaum-Boyden, D., Hazzard, W. R., Cain, J., Cheung, M. C., Kushwaha, R. S. & Albers, J. J. (1979). Atherosclerosis 33, 385–396.CrossRefGoogle Scholar
Atkins, R. C. (1972). Dr Atkins' Diet Revolution. New York: McKay.Google Scholar
Avogaro, P., Cazzolato, G., Bittolo Bon, G., Quinci, G. B. & Chinello, M. (1978). Atherosclerosis 31, 85–91.CrossRefGoogle Scholar
Barrett-Connor, E., Witztum, J. L. & Holdbrook, M. (1983). American Journal of Epidemiology 117, 186–192.CrossRefGoogle Scholar
Beveridge, J. M. T., Connell, W. F., Haust, H. A. & Mayer, G. A. (1960). Journal of Nutrition 71, 61–65.CrossRefGoogle Scholar
Bolzano, K., Haslauer, F. & Krempler, F. (1979). Atherosclerosis 33, 171–180.CrossRefGoogle Scholar
Brattsand, R. (1976). Atherosclerosis 23, 97–110.CrossRefGoogle Scholar
Bronsgeest-Schoute, D. C., Hermus, R. J. J., Dallinga-Thie, G. M. & Hautvast, J. G. A. J. (1979). American Journal of Clinical Nutrition 32, 2188–2192.CrossRefGoogle Scholar
Cole, T. G., Patch, W., Kuisk, B., Gonen, B. & Schonfeld, G. (1983). Journal of Clinical Endocrinology and Metabolism 56, 1108–1119.CrossRefGoogle Scholar
Corraze, G., Lacombe, C. & Nibbelink, M. (1984). Lipids 19, 812–814.CrossRefGoogle Scholar
Corraze, G., Lacombe, C. & Nibbelink, M. (1985 a). Nutrition Research 5, 781–787.CrossRefGoogle Scholar
Corraze, G., Lacombe, C. & Nibbelink, M. (1985 b). Experimental and Molecular Pathology 43, 260–267.CrossRefGoogle Scholar
Corraze, G., Lacombe, C. & Nibbelink, M. (1985 c). Lipids 20, 751–756.CrossRefGoogle Scholar
Eisele, B., Bates, S. R. & Wissler, R. W. (1980). Atherosclerosis 36, 9–24.CrossRefGoogle Scholar
Flaim, E., Ferreri, L. F., Thye, F. W., Hill, J. E. & Ritchey, S. J. (1981). American Journal of Clinical Nutrition 34, 1103–1108.CrossRefGoogle Scholar
Fless, G. M., Kirchausen, T., Fischer-Dzoga, K., Wissler, R. W. & Scanu, A. M. (1982). Atherosclerosis 41, 171–183.CrossRefGoogle Scholar
Flynn, M. A., Nolph, G. B., Flynn, T. C., Kahrs, R. & Krause, G. (1979). American Journal of Clinical Nutrition 32, 1051–1057.CrossRefGoogle Scholar
Hendrikx, A., Boni, L., Kieckens, L., Meulepas, E. & De Moor, P. (1979). American Journal of Clinical Nutrition 32, 1799–1804.CrossRefGoogle Scholar
Keys, A., Fidanza, F., Karvonen, M. J., Kimura, N. & Taylor, H. L. (1972). Journal of Chronic Diseases 25, 329–343.CrossRefGoogle Scholar
Kummerow, F. A., Kim, Y., Hull, M. D., Pollaro, J., Ilinov, P., Dorossiev, O. L. & Valek, J. (1977). American Journal of Clinical Nutrition 30, 664–673.CrossRefGoogle Scholar
Lacombe, C., Corraze, G. & Nibbelink, M. (1983). Lipids 18, 306–312.CrossRefGoogle Scholar
Lin, D. S. & Connor, W. E. (1980). Journal of Lipid Research 21, 1042–1052.CrossRefGoogle Scholar
Lowry, O. H., Rosebrough, H., Farr, A. L. & Randall, R. S. (1951). Journal of Biological Chemistry 193, 265–275.CrossRefGoogle Scholar
Mahley, R. W., Innerarity, T. L., Bersot, T. P., Lipson, A. & Margolis, S. (1978). Lancet ii, 807–809.CrossRefGoogle Scholar
Mahley, R. W., Innerarity, T. L., Weisgraber, K. H. & Fry, D. L. (1977). American Journal of Pathology 87, 205–226.Google Scholar
Mattson, F. H., Erickson, B. A. & Kligman, A. M. (1972). American Journal of Clinical Nutrition 25, 589–594.CrossRefGoogle Scholar
Mistry, P., Miller, N. E., Laker, M., Hazzard, W. R. & Lewis, P. (1981). Journal of Clinical Investigations 67, 493–502.CrossRefGoogle Scholar
Nestel, P. J. & Payser, A. (1976). Metabolism 25, 1591–1599.CrossRefGoogle ScholarPubMed
Noble, R. P. (1968). Journal of Lipid Research 9, 693–700.CrossRefGoogle Scholar
Pi-Sunyer, F. X. (1982). Bulletin of the New York Academy of Medicine 58, 263–274.Google Scholar
Porter, M. W., Yamanaka, W., Carlson, S. D. & Flynn, M. A. (1977). American Journal of Clinical Nutrition 30, 490–495.CrossRefGoogle Scholar
Quintao, E., Grundy, S. M. & Ahrens, E. H. (1971). Journal of Lipid Research 12, 233–247.CrossRefGoogle Scholar
Roberts, S. L., McMurry, M. P. & Connor, W. E. (1981). American Journal of Clinical Nutrition 34, 2092–2099.CrossRefGoogle Scholar
Rudel, L. L., Leathers, C. W., Bond, M. G. & Bullock, B. C. (1981). Arteriosclerosis 1, 144–145.CrossRefGoogle Scholar
Rudel, L. L., Shah, R. & Greene, D. G. (1979). Journal of Lipid Research 20, 55–65.CrossRefGoogle Scholar
St-Clair, R. W. & Leight, M. A. (1978). Biochimica et Biophysica Acta 530, 279–291.CrossRefGoogle Scholar
St-Clair, R. W., Greenspan, P. & Leight, M. (1983). Arteriosclerosis 3, 77–86.CrossRefGoogle Scholar
Scholz, K. E., Beynen, A. C. & West, C. E. (1982). Atherosclerosis 44, 85–97.CrossRefGoogle Scholar
Schonfeld, G., Patsch, W., Rudel, L. L., Nelson, C., Epstein, M. & Olson, R. E. (1982). Journal of Clinical Investigation 69, 1072–1080.CrossRefGoogle Scholar
Schouten, J. A., Van Gent, C. M., Popp-Snijders, C., Van Der Ven, E. A. & Van Der Voort, H. A. (1981). International Journal of Obesity 5, 333–340.Google Scholar
Sievet-Desrumeaux, C., Dedomder-Decoopman, E., Fruchart, J. C., Dewailli, P. & Sezille, G. (1979). Clinica Chimica Acta 95, 405–408.CrossRefGoogle Scholar
Sievet-Desrumeaux, C., Dedomder-Decoopman, E., Fruchart, J. C., Dewailli, P., Sezille, G. & Jaillard, J. (1980). Clinica Chimica Acta 107, 145–148.CrossRefGoogle Scholar
Slater, G., Mead, J., Dhopeshwarkar, G. & Alfin-Slater, R. B. (1976). Nutrition Reports International 14, 249–260.Google Scholar
Stillman, I. M. & Baker, S. S. (1967). The Doctor's Quick Weight Loss Diet. Englewood Cliffs, New Jersey: Prentice Hall.Google Scholar
Tan, M. H., Dickinson, M. A., Albers, J. J., Havel, R. J., Cheung, M. C. & Vigne, J. L. (1980). American Journal of Clinical Nutrition 33, 2559–2565.CrossRefGoogle Scholar
Taskinen, M. R. & Nikkila, E. A. (1979). Atherosclerosis 32, 289–299.CrossRefGoogle Scholar
Wechsler, J. G., Hutt, V., Wenzel, H., Klor, H. U. & Ditschuneit, H. (1981). International Journal of Obesity 5, 325–331.Google Scholar
Wolf, R. N. & Grundy, S. M. (1983). Arteriosclerosis 3, 160–169.CrossRefGoogle Scholar
Zimmerman, J., Kaufmann, N. A., Fainaru, M., Eisenberg, S., Oschry, Y., Friedlander, Y. & Stein, Y. (1984). Arteriosclerosis 4, 115–123.CrossRefGoogle Scholar