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The effect of zinc deficiency on glucose metabolism in meal-fed rats*

Published online by Cambridge University Press:  09 March 2007

Philip G. Reeves  and
Boyd L. O'Dell
Philip G. Reeves
Affiliation:
322 Chemistry, Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
Boyd L. O'Dell
Affiliation:
322 Chemistry, Department of Biochemistry, University of Missouri, Columbia, Missouri 65211, USA
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Abstract

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1. The incorporation of uniformly-labelled [14C]glucose into fatty acids and glycogen of adipose tissue and liver was used to assess the effects of zinc deficiency on glucose metabolism in meal-fed rats.

2. Throughout the study, identical feeding regimens were maintained between each of the Zn-deficient groups and their appropriate controls. The feeding regimens were either meal-feeding or ad lib. feeding.

3. Zn deficiency reduced [14C]glucose incorporation into fatty acids of epididymal fat pads of meal-fed rats by 75% when compared with meal-fed controls.

4. Zn deficiency caused a slight but significant decrease in [14C]glucose incorporation into liver fatty acids of meal-fed fats when compared with meal-fed controls.

5. Zn deficiency significantly increased [14C]glucose incorporation into liver glycogen of meal-fed rats in Expt. 2 but not in Expt 1.

6. Some effects of Zn deficiency on glucose metabolism were shown to be independent of the feeding regimen when a single daily meal was given to both Zn deficient and control groups. This method of feeding may be a useful approach to study the effects of Zn on glucose metabolism in the rat.

Type
Paper on General Nutrition
Information
British Journal of Nutrition , Volume 49 , Issue 3 , May 1983 , pp. 441 - 452
Copyright
Copyright © The Nutrition Society 1983

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