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Effect of vitamin A deficiency and Newcastle disease virus infection on IgA and IgM secretion in chickens

Published online by Cambridge University Press:  09 March 2007

Jan H. W. M. Rombout ,
S. Reinder Sijtsma ,
Clive E. West ,
Yannoula Karabinis ,
Oscar K. W. Sijtsma ,
Akke J. Van Der Zijpp  and
Guus Koch
Jan H. W. M. Rombout
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
S. Reinder Sijtsma
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands Department of Animal Husbandry, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Clive E. West
Affiliation:
Department of Human Nutrition, Wageningen Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands
Yannoula Karabinis
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Oscar K. W. Sijtsma
Affiliation:
Department of Experimental Animal Morphology and Cell Biology, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Akke J. Van Der Zijpp
Affiliation:
Department of Animal Husbandry, Wageningen Agricultural University, PO Box 338, 6700 AH Wageningen, The Netherlands
Guus Koch
Affiliation:
Department of Virology, Central Veterinary Institute, PO Box 365, 8200 AJ Lelystad, The Netherlands
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Abstract

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The effect of vitamin A deficiency or the lentogenic La Sota strain of Newcastle disease virus (NDV) infection, or both, on immunoglobulin (IgA and IgM) levels in bile and plasma were investigated. In addition, tissue distribution of IgA-, IgG- and IgM-containing cells was studied to establish the source of these Ig. Chickens (1-d-old) with limited vitamin A reserves were fed ad lib. on diets containing either marginal or adequate levels of vitamin A. At 4 weeks of age, half the chickens in each group were infected with NDV. The number of IgA- and IgM-containing cells was not significantly affected by vitamin A deficiency, demonstrating that neither class-switching nor homing of Ig-containing cells is influenced by vitamin A deficiency. Although bile IgM levels were not significantly different in vitamin A-deficient chickens compared with normal chickens, IgA levels were significantly lower. This decrease was even more pronounced in deficient NDV-infected chickens, despite the higher number of IgA-containing cells found in these birds. These results, together with the slightly increased levels of IgA in plasma of vitamin A-deficient chickens, suggest that the hepatobiliary transport of IgA is impaired by vitamin A deficiency and possibly also by NDV infection, although disturbed secretion by IgA-containing cells cannot be excluded

Keywords

Vitamin ANewcastle diseaseImmunoglobulinsChickens
Type
Vitamin A Status and Disease Interactions
Information
British Journal of Nutrition , Volume 68 , Issue 3 , November 1992 , pp. 753 - 763
Copyright
Copyright © The Nutrition Society 1992

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