Hostname: page-component-586b7cd67f-l7hp2 Total loading time: 0 Render date: 2024-11-20T09:29:42.341Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of thiocyanate ingestion through milk on thyroid hormone homeostasis in women

Published online by Cambridge University Press:  09 March 2007

Kishore K. Banerjee ,
P. Marimuthu ,
Piyali Bhattacharyya  and
Malay Chatterjee
Kishore K. Banerjee
Affiliation:
All India Institute of Hygiene and Public Health, 110 Chittaranjan Avenue, Calcutta 700 073, India
P. Marimuthu
Affiliation:
All India Institute of Hygiene and Public Health, 110 Chittaranjan Avenue, Calcutta 700 073, India
Piyali Bhattacharyya
Affiliation:
Division of Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
Malay Chatterjee
Affiliation:
Division of Biochemistry, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

A thyroid-hormonal evaluation of thirty-five women consuming commercially packed milk containing thiocyanate was carried out. The mean serum thiocyanate concentration, which was measured by the FeCl3 colour test, was significantly higher (P < 0.01) than that of control subjects. Serum thyroxine (T4), triiodothyronine (T3) and thyroid-stimulating hormone (TSH) concentrations of exposed women were compared with those of thirty-five control subjects. Thiocyanate ingestion was associated with lower levels of T4 (P <0.01) and higher levels of TSH (P < 0.01) compared with the control subjects. T3 was found to be higher in the women consuming thiocyanate-containing milk but the difference was not significant. The serum T4 level was found to be negatively correlated (r −0.359, P <0.05) while the TSH level was positively correlated (r 0.354, P < 0.05) with thiocyanate concentration in the exposed group. From this study, it appears that ingestion of milk with added thiocyanate impairs thyroid function.

Keywords

MilkThiocyanateThyroid
Type
Short communcication
Information
British Journal of Nutrition , Volume 78 , Issue 5 , November 1997 , pp. 679 - 681
Copyright
Copyright © The Nutrition Society 1997

References

REFERENCES

Babu, S. & Shenolikar, I. (1992) Thiocyanate ingestion through milk and its effects on serum triiodothyronine (T3) and thyroxine (T4) levels in monkeys fed low iodine diet. Indian Journal of Dairy Science 6, 45–47.Google Scholar
Banerjee, K. K. & Marimuthu, P. (1994) Effect of cigarette smoking on thyroid hormone homeostasis. Indian Journal of Medical Research 99, 74–76.Google ScholarPubMed
Benotti, J., Benotti, N., Pinos, S. & Gardyna, H. (1965) Determination of total iodine in urine, stool, diets and tissue. Clinical Chemistry 11, 932–936.CrossRefGoogle ScholarPubMed
Bhandarka, S. D. & Pillai, M. R. A. (1992) RIA Laboratory Manual. Bombay: Bhaba Atomic Research Centre.Google Scholar
Geen, W. L. (1978) Mechanisms of action of antithyroid compounds. In The Thyroid. A Fundamental and Clinical Text, pp. 77–79 [Werner, S.C. and Ingbar, S. H., editors]. New York: Harper and Row Publishers.Google Scholar
George, S. K. & Schenck, J. R. (1983) Thiocyanate inhibition of protein iodination by the chloramine-T method and rapid method for measurement of low levels of thiocyanate. Analytical Biochemistry 130, 417.CrossRefGoogle ScholarPubMed
Kalra, M. A. (1981) Variation in Bacteriological Quality of Milk Products Offered for Sale. A Review of Progress of Research in Dairy Science During the Last Decade. New Delhi: Indian Dairy Association.Google Scholar
Pechacek, T. F., Folsom, A. R., de Gaudermaris, R., Jacobs, D. R., Leupker, R. V., Gillum, R. F. & Blackburn, H. (1985) Smoke exposure in pipe and cigar smokers: serum thiocyanate measures. Journal of the American Medical Association 254, 3330–3332.CrossRefGoogle ScholarPubMed
Singh, R. S. & Ranganathan, B. (1981) Microbiological Aspects of Handling, Processing and Storage of Milk and Milk Products. A Review of Progress of Research in Dairy Science During the Last Decade. New Delhi: Indian Dairy Association.Google Scholar
Vogel, S. N., Sultan, T. R. & Ten Eyck, R. P. (1981) Cyanide poisoning. Clinical Toxicology 18, 367–383.CrossRefGoogle ScholarPubMed