Hostname: page-component-78c5997874-ndw9j Total loading time: 0 Render date: 2024-11-08T21:35:55.671Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of tea catechins on postprandial plasma lipid responses in human subjects

Published online by Cambridge University Press:  08 March 2007

Tomonori Unno ,
Motomi Tago ,
Yuko Suzuki ,
Ayumu Nozawa ,
Yuko M Sagesaka ,
Takami Kakuda ,
Kazutada Egawa  and
Kazuo Kondo
Tomonori Unno*
Affiliation:
Central Research Institute, ITO EN, Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, 421-0516, Japan
Motomi Tago
Affiliation:
Institute of Environmental Science for Human Life, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo, 112-8610, Japan
Yuko Suzuki
Affiliation:
Central Research Institute, ITO EN, Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, 421-0516, Japan
Ayumu Nozawa
Affiliation:
Central Research Institute, ITO EN, Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, 421-0516, Japan
Yuko M Sagesaka
Affiliation:
Central Research Institute, ITO EN, Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, 421-0516, Japan
Takami Kakuda
Affiliation:
Central Research Institute, ITO EN, Ltd., 21 Mekami, Sagara-cho, Haibara-gun, Shizuoka, 421-0516, Japan
Kazutada Egawa
Affiliation:
Nihonbashi Egawa Clinic, 1-1-3 Yaesu, Chuo-ku, Tokyo, 103-0028, Japan
Kazuo Kondo
Affiliation:
Institute of Environmental Science for Human Life, Ochanomizu University, 2-1-1 Ohtsuka, Bunkyo-ku, Tokyo, 112-8610, Japan
*
*Corresponding author: Dr Tomonori Unno, fax +81 548 54 0763, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Epidemiological surveys suggest that a higher intake of tea may be associated with a lower risk of CHD. There is accumulating evidence that postprandial lipaemia makes a substantial contribution to the incidence of CHD. Our aim was, therefore, to evaluate the effect of tea catechins (major ingredients in green tea) on postprandial lipid responses in human subjects after the consumption of test meals. In a randomized triple-crossover design, nine male subjects with mild or borderline hypertriacylglycerolaemia consumed 10 (control), 224 (moderate dose) and 674 mg (high dose) of the assigned tea catechins three times each along with a standardized light meal consisting of a piece of bread spread with 20 g butter. Plasma lipids were measured in the fasting state and 1, 2, 3, 4 and 6 h after consuming the light meal. Results showed that, compared with the control, moderate and high doses of tea catechins reduced the incremental area under the plasma triacylglycerol curves by 15·1 and 28·7 %, respectively. Next, the rapid elevation of remnant-like particle cholesterol was significantly inhibited by a high dose of tea catechins 2 h after consuming the light meal (P<0·01). In the range of tea catechin dosages, no significant differences were observed in the postprandial responses for plasma total cholesterol or NEFA at any time point. In conclusion, this trial demonstrated that tea catechins attenuated the postprandial increase in plasma triacylglycerol levels following a fat load. These results may provide evidence for one of the possible mechanisms involved in lowering the incidence of CVD, and may prove useful in further studies on the beneficial health effects of tea drinking.

Keywords

Tea catechinsTriacylglycerolsRemnant lipoproteinPostprandial lipaemia
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 4 , April 2005 , pp. 543 - 547
Copyright
Copyright © The Nutrition Society 2005

References

Armand, M, Pasquier, B, André, M, Borel, P, Senft, M, Peyrot, J, Salducci, J, Portugal, H, Jaussan, V & Lairon, D (1999) Digestion and absorption of 2 fat emulsions with different droplet sizes in the human digestive tract. Am J Clin Nutr 70, 1096–1106.CrossRefGoogle ScholarPubMed
Chan, PT, Fong, WP, Cheung, YL, Huang, Y, Ho, WKK & Chen, Z (1999) Jasmine green tea epicatechins are hypolipidemic in hamsters ( Mesocricetus auratus ) fed a high fat diet. J Nutr 129, 1094–1101.CrossRefGoogle Scholar
Hollman, PC, Fesken, EJ & Katan, MB (1999) Tea flavonoids in cardiovascular disease and cancer epidemiology. Proc Soc Exp Biol Med 220, 198–202.Google ScholarPubMed
Igarashi, M, Hirata, A & Yamauchi, T (2003) Clinical utility and approach to estimate postprandial hypertriglycemia by a newly designed oral fat-loading test. J Atheroscler Thromb 10, 314–320.CrossRefGoogle ScholarPubMed
Imai, K & Nakachi, K (1995) Cross sectional study of effects of green tea on cardiovascular and liver diseases. Br Med J 310, 693–696.CrossRefGoogle ScholarPubMed
Jeppesen, J, Hein, HO, Suadicani, P & Gyntelberg, F (1998) Triglyceride concentration and ischemic heart disease. An eight-year follow-up in the Copenhagen male study. Circulation 97, 1029–1036.CrossRefGoogle ScholarPubMed
Jialal, I & Devaraj, S (2002) Remnant lipoproteins: measurement and clinical significance. Clin Chem 48, 217–219.CrossRefGoogle ScholarPubMed
Juhel, C, Armand, M, Pafumi, Y, Rosier, C, Vandermander, J & Lairon, D (2000) Green tea extract (AR25 ® ) inhibits lipolysis of triglycerides in gastric and duodenal medium in vitro. J Nutr Biochem 11, 45–51.CrossRefGoogle ScholarPubMed
Kondo, K, Hosoda, K, Iwamoto, T, Kusumoto, A, Hirano, R, Matsumoto, A & Itakura, H (1998) Red wine improves postprandial status XIIIth International Symposium on Drugs Affecting Liquid Metabolism (DALM) 33 Florence, Italy Fondazione Giovanni Lorenzini Medical Science FoundationGoogle Scholar
Kondo, S, Xiao, J, Takahashi, N, Miyaji, K, Iwatsuki, K & Kokubo, S (2004) Suppressive effects of dietary fiber in yogurt on the postprandial serum lipid levels in healthy adult male volunteers. Biosci Biotechnol Biochem 68, 1135–1138.CrossRefGoogle ScholarPubMed
Kris-Etherton, PM & Keen, CL (2002) Evidence that the antioxidant flavonoids in tea and cocoa are beneficial for cardiovascular health. Curr Opin Lipidol 13, 41–49.CrossRefGoogle ScholarPubMed
Lakenbrink, C, Lapczynski, S, Maiwald, B & Engelhardt, UH (2000) Flavonoids and other polyphenols in consumer brews of tea and other caffeinated beverages. J Agric Food Chem 48, 2848–2852.CrossRefGoogle ScholarPubMed
McKay, DL & Blumberg, JB (2002) The role of tea in human health: an update. J Am Coll Nutr 21, 1–13.CrossRefGoogle ScholarPubMed
Matsumoto, N, Okushio, K & Hara, Y (1998) Effect of black tea polyphenols on plasma lipids in cholesterol-fed rats. J Nutr Sci Vitaminol 44, 337–342.CrossRefGoogle ScholarPubMed
Mattes, RD (2001) Oral exposure to butter, but not fat replacers elevates postprandial triacylglycerol concentration in human subjects. J Nutr 131, 1491–1496.CrossRefGoogle ScholarPubMed
Matthews, JNS, Altman, DG, Campbell, MJ & Royston, P (1990) Analysis of serial measurements in medical research. Br Med J 300, 230–235.CrossRefGoogle ScholarPubMed
Pal, S, Naissides, M & Mamo, J (2004) Polyphenolics and fat absorption. Int J Obes 28, 324–326.CrossRefGoogle ScholarPubMed
Peters, U, Poole, C & Arab, L (2001) Does tea affect cardiovascular disease? A meta-analysis. Am J Epidemiol 154, 495–503.CrossRefGoogle ScholarPubMed
Raederstorff, DG, Schlachter, MF, Elste, V & Weber, P (2003) Effect of EGCG on lipid absorption and plasma lipid levels in rats. J Nutr Biochem 14, 326–332.CrossRefGoogle ScholarPubMed
Sanders, TAB (2003) Dietary fat and postprandial lipids. Curr Atheroscler Rep 5, 445–451.CrossRefGoogle ScholarPubMed
Schaefer, EJ (2002) Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 75, 191–212.CrossRefGoogle ScholarPubMed
Shige, H, Ishikawa, T & Higashi, K (1998) Effects of soy protein isolate (SPI) and casein on the postprandial lipemia in normolipidemic men. J Nutr Sci Vitaminol 44, 113–127.CrossRefGoogle ScholarPubMed
Syvänne, M & Taskinen, MR (1997) Lipids and lipoproteins as coronary risk factors in non-insulin-dependent diabetes mellitus. Lancet 350 Suppl. 1 20–23.CrossRefGoogle ScholarPubMed
Thomsen, C, Rasmussen, O, Lousen, T, Holst, JJ, Fenselau, S, Schrezenmeir, J & Hermansen, K (1999) Differential effects of saturated and monounsaturated fatty acids on postprandial lipemia and incretin responses in healthy subjects. Am J Clin Nutr 69, 1135–1143.CrossRefGoogle ScholarPubMed
Thomsen, C, Storm, H, Holst, JJ & Hermansen, K (2003) Differential effects of saturated and monounsaturated fats on postprandial lipemia and glucagons-like peptide 1 responses in patients with type 2 diabetes. Am J Clin Nutr 77, 605–611.CrossRefGoogle Scholar
Tijburg, LBM, Mattern, T, Folts, JD, Weisgerber, UM & Katan, MB (1997) Tea flavonoids and cardiovascular disease: a review. Crit Rev Food Sci Nutr 37, 771–785.CrossRefGoogle ScholarPubMed
Twickler, TB, Dallinga-Thie, GM, Cohn, JS & Chapman, MJ (2004) Elevated remnant-like particle cholesterol concentration. A characteristic feature of the atherogenic lipoprotein phenotype. Circulation 109, 1918–1925.CrossRefGoogle ScholarPubMed
Vinson, JA & Dabbagh, YA (1998) Effect of green and black tea supplementation on lipids, lipid oxidation and fibrinogen in the hamster: mechanisms for the epidemiological benefits of tea drinking. FEBS Lett 433, 44–46.CrossRefGoogle ScholarPubMed
Yang, CS & Landau, JM (2000) Effects of tea consumption on nutrition and health. J Nutr 130, 2409–2412.CrossRefGoogle ScholarPubMed