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The effect of short-term calcium supplementation on biochemical markers of bone metabolism in healthy young adults

Published online by Cambridge University Press:  09 March 2007

Fiona Ginty ,
Albert Flynn  and
Kevin D. Cashman
Fiona Ginty
Affiliation:
Department of Nutrition, University College, Cork, Ireland
Albert Flynn
Affiliation:
Department of Nutrition, University College, Cork, Ireland
Kevin D. Cashman*
Affiliation:
Department of Nutrition, University College, Cork, Ireland
*
*Corresponding author:Dr Kevin Cashman, fax +353 21 270244, email [email protected]
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Abstract

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The influence of Ca supplementation of the usual diet for 14d on biochemical markers of bone turnover was investigated in healthy young adults aged 21–26 years. In a crossover study, eighteen subjects (five male and thirteen female) were randomly assigned to their self-selected diet (about 22 mmol Ca/d) or their self-selected diet with a 20 mmol/d Ca supplement (about 40 mmol Ca/d) for 14d followed by crossover to the alternative diet for a further 14d. During each dietary period fasting morning first void urine samples (last 3d) and fasting blood serum samples (morning of twelfth day) were collected. Ca supplementation reduced urinary excretion of pyridinoline (14%) and deoxypyridinoline (16%) (biochemical markers of bone resorption) but had no effect on biochemical markers of bone formation (serum osteocalcin and bone-specific alkaline phosphatase; EC 3.1.3.1). It is concluded that Ca supplementation of the usual diet in young adults suppresses bone resorption over a 2-week period. If sustained, this could result in suppression of the bone remodelling rate and an increase in bone mass over time. The findings of this short-term study with a relatively small number of young adults highlight the need for a longer-term intervention study of the effect of increased Ca intake on bone mass in this age group.

Keywords

CalciumBoneBiochemical markersYoung adults
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 5 , November 1998 , pp. 437 - 443
Copyright
Copyright © The Nutrition Society 1998

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