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Effect of experimental zinc deficiency and repletion on some immunological variables in guinea-pigs

Published online by Cambridge University Press:  09 March 2007

P. C. Verma ,
R. P. Gupta ,
J. R. Sadana  and
R. K. Paul Gupta
P. C. Verma
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
R. P. Gupta
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
J. R. Sadana
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
R. K. Paul Gupta
Affiliation:
Department of Veterinary Pathology, College of Veterinary Sciences, Haryana Agricultural University, Hisar-125 004, India
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Abstract

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1. Cellular and humoral immune responses were studied in guinea-pigs fed on zinc-deficient (ZnD), Zn-adequate (control) and Zn-replete diets containing 1·25, 50 and 100 mg Zn/kg diet respectively.

2. It was found that the ZnD guinea-pigs had significantly decreased ability to elicit delayed-type hypersensitivity (DTH) response against sheep erythrocytes as compared with controls on the 9th day of immunization. This was further substantiated by histological examination of DTH-positive skin sections.

3. A significant reduction in direct splenic plaque-forming-cell response and haemagglutinating-antibody titre was also observed in ZnD guinea-pigs.

4. Serum electrophoretic studies revealed a highly disordered protein profile with a significantly depressed value for γ-globulin.

5. Zn repletion of the previously ZnD group resulted in marked, though incomplete, restoration of immunological responses.

Type
General Nutrition papers
Information
British Journal of Nutrition , Volume 59 , Issue 1 , January 1988 , pp. 149 - 154
Copyright
Copyright © The Nutrition Society 1988

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