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Effect of dietary protein, dichlorodiphenyltrichloroethane (DDT) and hexachlorocyclohexane (HCH) on hepatic microsomal enzyme activity in rats

Published online by Cambridge University Press:  24 July 2007

Girija Balakrishnan ,
M. Ramachandran ,
B. D. Banerjee  and
Q. Z. Hussain
Girija Balakrishnan
Affiliation:
Biochemistry Division, National Institute of Communicable Diseases, Delhi-110 054, 22 Sham Nath Marg, India
M. Ramachandran
Affiliation:
Biochemistry Division, National Institute of Communicable Diseases, Delhi-110 054, 22 Sham Nath Marg, India
B. D. Banerjee
Affiliation:
Biochemistry Division, National Institute of Communicable Diseases, Delhi-110 054, 22 Sham Nath Marg, India
Q. Z. Hussain
Affiliation:
Biochemistry Division, National Institute of Communicable Diseases, Delhi-110 054, 22 Sham Nath Marg, India
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Abstract

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1. Albino rats were fed on diets containing 30, 120 or 200 g protein/kg with or without the incorporation of dichlorodiphenyltrichloroethane (DDT) or hexachlorocyclohexane (HCH) at 100 mg/kg diet for 4 weeks.

2. The activities of the liver microsomal enzymes NADPH-cytochrome reductase (EC 1.6.2.4), flavoprotein- linked monooxygenase (EC 1.14.14.1)and O-demethylase were significantly greater in animals fed on 120 and 200 g protein/kg diet compared with those fed on 30 g protein/kg diet.

3. The inclusion of DDT or HCH at all protein intakes led to further significant rises in microsomal enzyme activities but the increases were much greater for animals receiving the 120 and 200 g protein/kg diets than for those receiving the 30 g protein/kg diet.

4. The results imply that detoxification of DDT or HCH was carried out more effectively at the higher protein intakes.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 54 , Issue 3 , November 1985 , pp. 563 - 566
Copyright
Copyright © The Nutrition Society 1985

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