Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-25T02:44:27.324Z Has data issue: false hasContentIssue false
  • English
  • Français

The effect of dietary polyunsaturated fat on cation transport and hypertension in the rat

Published online by Cambridge University Press:  09 March 2007

Gordon E. Murray ,
Raman Nair  and
John Patrick
Gordon E. Murray
Affiliation:
Departments of Biochemistry and Pediatrics, University of Ottawa, Ottawa, CanadaKIH 8M5
Raman Nair
Affiliation:
Departments of Biochemistry and Pediatrics, University of Ottawa, Ottawa, CanadaKIH 8M5
John Patrick
Affiliation:
Departments of Biochemistry and Pediatrics, University of Ottawa, Ottawa, CanadaKIH 8M5
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Essential hypertension is associated with increased intracellular sodium in both erythrocytes and leucocytes. Reports in the literature indicate that increasing the level of polyunsaturated fat in the diet reduces hypertension. In the present study, spontaneously hypertensive rats (Wistar-Kyoto, which develop systolic blood pressures in excess of 140 mmHg by 8 weeks of age) were fed on high-fat diets (40% energy derived from fat), the fat being maize oil (high in polyunsaturated fatty acids, PUFA) and coconut oil (low in PUFA).

2. Significantly higher blood pressures developed by 110 d of age in the rats fed on a high-PUFA diet, compared with those fed on the low-PUFA diet.

3. In thymocytes, ouabain-sensitive efflux rate constants were significantly lower in the group fed on the high-PUFA diet. Ouabain-insensitive efflux rate constants were unaffected by diet.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 56 , Issue 3 , November 1986 , pp. 587 - 593
Copyright
Copyright © The Nutrition Society 1986

References

REFERENCES

Beare-Rogers, J. L., Gray, L., Nera, E. A. & Levin, O. L. (1975). Nutrition and Metabolism 23, 335–346.CrossRefGoogle Scholar
Bernhart, F. W. & Tornarelli, R. M. (1966). Journal of Nutrition 89, 495–500.CrossRefGoogle Scholar
Blaustein, M. P. (1977). American Journal of Physiology 232, C165–C173.CrossRefGoogle Scholar
Bligh, E. C. & Dyer, W. J. (1959). Canadian Journal of Biochemistry and Physiology 37, 911–917.CrossRefGoogle Scholar
Box, B. M. & Mogenson, G. J. (1982). Nutrition Research 2, 619–627.CrossRefGoogle Scholar
Burstyn, P. G. & Firth, W. R. (1975). Cardiovascular Research 9, 807–810.CrossRefGoogle Scholar
Burstyn, P. G. & Husbands, D. R. (1980). Cardiovascular Research 14, 185–191.CrossRefGoogle Scholar
Carroll, K. K. (1961). Nature 191, 377–378.CrossRefGoogle Scholar
Dickens, P., Dusting, G. J., Doyle, A. E. & Martin, T. J. (1982). Clinical and Experimental Pharmacology and Physiology 9, 253–257.CrossRefGoogle Scholar
Düsing, R., Scherhag, R., Glanzer, K., Büdde, U. & Kramer, H. (1983). American Journal of Physiology 244, H228–H233.Google Scholar
Dusting, G. J., Davies, W., Drysdale, T. & Doyle, A. E. (1981). Clinical and Experimental Pharmacology and Physiology 8, 435–440.CrossRefGoogle Scholar
Edmondson, R. P. S., Thomas, R. D., Hilton, P. J., Patrick, J. & Jones, N. F. (1975). Lancet i, 1003–1005.CrossRefGoogle Scholar
Hamlyn, J. M., Ringel, R., Schaeffer, J., Levinson, P. D., Hamilton, B. P., Kowarski, A. A. & Blaustein, M. P. (1982). Nature 300, 650–652.CrossRefGoogle Scholar
Heagerty, A. M., Milner, M., Bing, R. F., Thurston, H. & Swales, J. D. (1982). Lancet ii, 894–896.CrossRefGoogle Scholar
Hunt, S. C., Williams, R. R., Smith, J. B., Ash, K. O. & Kuida, H. (1986). CIinical and Experimental Hypertension A7, 1409–1426.Google Scholar
Iacono, J. M., Dougherty, R. M. & Puska, P. (1982). Hypertension 4 (Suppl. III), 34–42.CrossRefGoogle Scholar
Iacono, J. M., Puska, P., Dougherty, R. M., Pietinen, P., Vartiainen, E., Leino, U., Mutanen, M. & Moisio, S. (1983). American Journal of Clinical Nutrition 38, 860–869.CrossRefGoogle Scholar
Innis, S. M. & Clandinin, M. T. (1981 a). Biochemical Journal 193, 155–167.CrossRefGoogle Scholar
Innis, S. M. & Clandinin, M. T. (1981 b). Biochemical Journal 198, 167–175.CrossRefGoogle Scholar
Jones, R. B., Patrick, J. & Hilton, P. J. (1981). Clinical Science 61, 313–316.CrossRefGoogle Scholar
Klausner, R. D., Kleinfeld, A. M., Hoover, A. M. & Karnovsky, M. J. (1980). Journal of Biological Chemistry 255, 1286–1294.CrossRefGoogle Scholar
Mason, J. C., Poston, L. & Hilton, P. J. (1985). Clinical Science 68, 11–14.CrossRefGoogle Scholar
Poston, L., Sewell, R. B., Wilkinson, S. P., Richardson, P. J., Williams, R., Clarkson, E. M., acGregor, G. A. & De Wardener, H. E. (1981). British Medical Journal 282, 847–849.CrossRefGoogle Scholar
Puska, P., Nissinen, A., Vartiainen, E., Dougherty, R., Mutanen, M., Iacono, J. M., Korhonen, H. J., Pietinen, P., Leino, U. & Moisio, S. (1983). Lancet i, 1–5.CrossRefGoogle Scholar
Puska, P., Nissinen, A., Pietinen, P. & Iacono, J. (1985). Scandinavian Journal of Clinical and Laboratory Investigation 176 (Suppl.), 62–80.Google Scholar
Tosteson, D. C., Adragna, N., Bizet, I., Solomon, H. & Canessa, M. (1981). Clinical Science 61 (Suppl. 7), 5s–10s.CrossRefGoogle Scholar
Wahle, K. W. J. (1983). Proceedings of the Nutrition Sociery 42, 273–287.CrossRefGoogle Scholar
Wexler, B. C. (1981). Endocrinology 108, 981–989.CrossRefGoogle Scholar