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Effect of dietary phytic acid on zinc absorption in the healthy elderly, as assessed by serum concentration curve tests

Published online by Cambridge University Press:  09 March 2007

François Couzy ,
Robert Mansourian ,
Arielle Labate ,
Sylvie Guinchard ,
Dirk H. Montagne  and
Henri Dirren
François Couzy*
Affiliation:
Nestlé Research Centre – NESTEC Ltd., PO Box 44, CH-1000 Lausanne 26, Switzerland
Robert Mansourian
Affiliation:
Nestlé Research Centre – NESTEC Ltd., PO Box 44, CH-1000 Lausanne 26, Switzerland
Arielle Labate
Affiliation:
Nestlé Research Centre – NESTEC Ltd., PO Box 44, CH-1000 Lausanne 26, Switzerland
Sylvie Guinchard
Affiliation:
Nestlé Research Centre – NESTEC Ltd., PO Box 44, CH-1000 Lausanne 26, Switzerland
Dirk H. Montagne
Affiliation:
Nestlé Research & Development Centre, Sonnrainstrasse 19, PO Box 12, CH-3510 Konolfingen 1, Switzerland
Henri Dirren
Affiliation:
Nestlé Research Centre – NESTEC Ltd., PO Box 44, CH-1000 Lausanne 26, Switzerland
*
*Corresponding author: Dr F. Couzy, fax +41 21 785 85 56, email [email protected]
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Abstract

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Zn absorption was investigated in healthy elderly subjects aged 71–78 years and in young subjects aged 23–43 years using serum concentration curve (SCC) tests. Both groups had similar Zn and protein status. The increase in serum Zn was monitored for 180 min after ingestion of 200ml of soya milk enriched with 50mg of Zn. Three levels of phytic acid were used: 0g/200ml (totally dephytinized soya milk), 0.13 g/200ml (half dephytinized), and 0.26 g/200ml (natural phytic acid content). In a first study the effect of 0 v. 0.26 g/200 ml phytic acid was compared in 10 elderly and 10 young subjects, each subject receiving both treatments. In a second study soya milks with 0 and 0.13 g/200ml were tested in nine elderly and ten young subjects, again receiving both treatments. Mean areas under the curve of the SCC tests conducted with the 0 g/200 ml soya milk were found to be the same in both studies. Phytic acid strongly depressed Zn absorption in both studies (P ≤ 0.05), but to a greater extent at the 0.26 g/200ml level. No difference was found between the groups of young and elderly subjects. Therefore, no significant effect of aging on Zn absorption, as evaluated by the SCC test, or on the inhibitory effect of phytic acid was detected.

Keywords

Zinc absorptionElderlyPhytic Acid
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , Issue 2 , February 1998 , pp. 177 - 182
Copyright
Copyright © The Nutrition Society 1998

References

Aamodt, RL, Rumble, WF & Henkin, RI (1983) Zinc absorption in humans. Effects of age, sex, and food. In Nutritional Bioavail-ability of Zinc, pp. 61–82 [Inglett, GE, editor]. Washington DC: American Chemical Society.CrossRefGoogle Scholar
August, D, Janghorbani, M & Young, VR (1989) Determination of zinc and copper absorption at three dietary Zn-Cu ratios by using stable isotope methods in young adult and elderly subjects. American Journal of Clinical Nutrition 50, 1457–1463.CrossRefGoogle ScholarPubMed
Baghurst, KI & Record, SJ (1987) The vitamin and mineral intake of a free-living young elderly Australian population in relation to total diet and supplementation practices. Human Nutrition: Applied Nutrition 41A, 327–337.Google Scholar
Bales, CW, Steinman, LC, Freeland-Graves, JH, Stone, JM & Young, RK (1986) The effect of age on plasma zinc uptake and taste acuity. American Journal of Clinical Nutrition 44, 664–669.CrossRefGoogle ScholarPubMed
Bogden, JD, Oleske, JM, Munves, EM, Lavenhar, MA, Bruening, KS, Kemp, FW, Holding, KJ, Denny, TN & Louria, DB (1987) Zinc and immunocompetence in the elderly: baseline data on zinc nutriture and immunity in unsupplemented subjects. American Journal of Clinical Nutrition 46, 101–109.CrossRefGoogle ScholarPubMed
Bogden, JD, Oleske, JM, Lavenhar, MA, Munves, EM, Kemp, FW, Bruening, KS, Holding, KJ, Denny, TN, Guarino, MA & Holland, BK (1990) Effects of one year of supplementation with zinc and other micronutrients on cellular immunity in the elderly. Journal of the American College of Nutrition 9, 214–225.CrossRefGoogle ScholarPubMed
Bremner, I & Beattie, JH (1990) Metallothionein and the trace minerals. Annual Review of Nutrition 10, 63–83.CrossRefGoogle ScholarPubMed
Bunker, VW, Hinks, LJ, Lawson, MS & Clayton, BE (1984) Assessment of zinc and copper status of healthy elderly people using metabolic balance studies and measurement of leucocyte concentrations. American Journal of Clinical Nutrition 40, 1096–1102.CrossRefGoogle ScholarPubMed
Couzy, F, Lafargue, P & Guezennec, CY (1990) Zinc metabolism in the athlete: influence of training, nutrition and other factors. International Journal of Sports Medicine 4, 263–266.CrossRefGoogle Scholar
Couzy, F, Kastenmayer, P, Mansourian, R, Guinchard, S, Munoz-Box, R & Dirren, H (1993) Zinc absorption in the healthy elderly and the effect of diet. American Journal of Clinical Nutrition 58, 690–694.CrossRefGoogle ScholarPubMed
Faure, H, Favier, A, Tripier, M & Arnaud, J (1990) Determination of the major zinc fractions in human serum by ultrafiltration. Biological Trace Element Research 24, 25–37.CrossRefGoogle ScholarPubMed
Fickel, JJ, Freeland-Graves, JH & Roby, MJ (1986) Zinc tolerance tests in zinc deficient and zinc supplemented diets. American Journal of Clinical Nutrition 43, 47–58.CrossRefGoogle ScholarPubMed
Gardiner, PE, Ottaway, JM, Fell, GS & Burns, RR (1981) The application of gel filtration and electrothermal atomic absorption spectrometry to the speciation of protein-bound zinc and copper in human blood serum. Analytica Chimica Acta 124, 281–294.CrossRefGoogle Scholar
Gersovitz, M, Munro, HN, Udall, J & Young, VR (1981) Albumin synthesis in young and elderly subjects using a new stable isotope methodology: response to level of protein intake. Metabolism 29, 1075–1086.CrossRefGoogle Scholar
Haider, M & Haider, SQ (1984) Assessment of protein-calorie malnutrition. Clinical Chemistry 30, 1286–1299.CrossRefGoogle ScholarPubMed
Hambidge, KM, Goodall, MJ, Stall, C & Pritts, J (1989) Post-prandial and daily changes in plasma zinc. Journal of Trace Elements and Electrolytes in Health and Disease 3, 55–57.Google ScholarPubMed
Harland, BF & Oberleas, D (1987) Phytate in foods. World Review of Nutrition and Dietetics 52, 235–259.CrossRefGoogle ScholarPubMed
Kruse–Jarres, JD (1989) The significance of zinc for humoral and cellular immunity. Journal of Trace Elements and Electrolytes in Health and Disease 3, 1–8.Google ScholarPubMed
Makower, RU (1970) Extraction and determination of phytic acid in beans (Phaseolus vulgaris). Cereal Chemistry 47, 288–295.Google Scholar
National Research Council (1989) Recommended Dietary Allowances. Washington, DC: National Academy of Sciences.Google Scholar
Pekarek, RS, Wannemacher, RW & Beisel, WR (1972) The effect of Leucocytic Endogenous Mediator (LEM) on the tissue distribution of zinc and iron. Proceedings of the Society for Experimental Biology and Medicine 140, 685–688.CrossRefGoogle ScholarPubMed
Prasad, AS, Oberleas, D & Halsted, JA (1965) Determination of zinc in biological fluids by atomic absorption spectrophotometry in normal and cirrhotic subjects. Journal of Laboratory and Clinical Medicine 66, 508–516.Google ScholarPubMed
Puri, P, Kenny, D & Guiney, EJ (1981) The need to consider changes in plasma proteins in interpreting post-operative plasma zinc changes. Clinica Chimica Acta 110, 341–344.CrossRefGoogle ScholarPubMed
Rolland-Cachera, MF, Cole, TJ, Sempé, M, Tichet, J, Rossignol, C & Charraud, A (1991) Body Mass Index variations: centiles from birth to 87 years. European Journal of Clinical Nutrition 45, 13–21.Google Scholar
Russell, RM (1986) Implications of gastric atrophy for vitamin and mineral nutriture. In Nutrition and Aging, pp. 59–69 [Hutchinson, ML and Munro, HN, editors]. New York: Academic Press.CrossRefGoogle Scholar
Sahyoun, NR, Otradovec, CL, Hartz, SC, Jacob, RA, Peters, H, Russell, RM & McGandy, RB (1988) Dietary intakes and biochemical indicators of nutritional status in an elderly, institutionalized population. American Journal of Clinical Nutrition 47, 524–533.CrossRefGoogle Scholar
Srinavas, U, Braconier, JH, Jeppson, B, Abdulla, M, Akesson, B & Ockerman, PA (1988) Trace element alterations in infectious diseases. Scandinavian Journal of Laboratory and Clinical Medicine 48, 495–500.CrossRefGoogle Scholar
Swanson, CA, Mansourian, R, Dirren, H & Rapin, C-H (1988) Zinc status of healthy elderly adults: response to supplementation American Journal of Clinical Nutrition 48, 343–349.Google Scholar
Thomas, AJ, Bunker, VW, Hinks, LJ, Sodha, D, Mullee, MA & Clayton, BE (1988) Energy, protein, zinc and copper status of twenty-one elderly inpatients: analysed dietary intakes and biochemical indices. British Journal of Nutrition 59, 181–191.CrossRefGoogle ScholarPubMed
Thomson, ABR & Keelan, M (1986) The aging gut. Canadian Journal of Physiology and Pharmacology 64, 30–38.CrossRefGoogle ScholarPubMed
Turnlund, JR, Durkin, N, Costa, F & Margen, S (1986) Stable isotope studies of zinc absorption and retention in young and elderly men. Journal of Nutrition 116, 1239–1247.CrossRefGoogle Scholar
Wada, L, Turnlund, JR & King, JC (1985) Zinc utilization in young men fed adequate and low zinc intakes. Journal of Nutrition 115, 1345–1354.CrossRefGoogle ScholarPubMed
Watson, MS (1988) Plasma zinc uptake and test acuity (Letter to the Editor). American Journal of Clinical Nutrition 47, 336–344.CrossRefGoogle Scholar
Weigand, E & Kirchgessner, M (1980) Total true efficiency of zinc utilization: determination and homeostatic dependence upon the zinc supply status in young rats. Journal of Nutrition 110, 469–480.CrossRefGoogle ScholarPubMed
Williams, RJP (1989) An introduction to the biochemistry of zinc. In Zinc in Human Biology, pp. 15–32. [Mills, CF, editor]. Berlin:Springer Verlag.CrossRefGoogle Scholar