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Effect of consumption of soy isoflavones on behavioural, somatic and affective symptoms in women with premenstrual syndrome

Published online by Cambridge University Press:  08 March 2007

M. Bryant ,
A. Cassidy ,
C. Hill ,
Jonathan Powell ,
Duncan Talbot  and
L. Dye
M. Bryant
Affiliation:
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
A. Cassidy
Affiliation:
School of Medicine, Health Policy & Practice, University of East Anglia, Norwich NR4 755, UK
C. Hill
Affiliation:
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
Jonathan Powell
Affiliation:
Unilever R&D, Colworth, Sharnbrook, Bedfordshire, MK44 1LQ, UK
Duncan Talbot
Affiliation:
Unilever R&D, Colworth, Sharnbrook, Bedfordshire, MK44 1LQ, UK
L. Dye*
Affiliation:
BioPsychology Group, Institute of Psychological Sciences, University of Leeds, Leeds, LS2 9JT, UK
*
*Corresponding author: Dr Louise Dye, fax +44 (0)113 343 5749, email [email protected]
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Abstract

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Up to 80 % of the Western female population experience premenstrual syndrome (PMS). Long-term pharmacological therapy is unacceptable to most women, and is not warranted for moderate symptoms. Nutritional therapies are popular, but lack a clear evidence base. Anecdotal evidence suggests beneficial effects of soy isoflavones because of their influence on endogenous oestrogen and actions on specific tissues. The effect of isolated soya protein (ISP) containing 68 mg/d (aglycone equivalents) soy isoflavones (IF) on premenstrual symptom severity was studied in a seven-menstrual cycle, double-blind, placebo-controlled, crossover intervention study in twenty-three women with prospectively confirmed PMS aged 18–35 years and BMI 19–30 kg/m2. ISP containing IF or milk protein placebo was consumed for two complete menstrual cycles. ISP containing IF (genistein, daidzein, equol) were measured in 24 h urine samples. After two cycles of ISP containing IF intervention, total symptoms (F(2,36) 8·20, P=0·000) and physical symptoms (F(2,36) 8·18, P=0·000) were significantly reduced compared with baseline after both active and placebo treatments, although differences between active and placebo treatment were non-significant. Specific premenstrual symptoms, headache (F(2,32) 4·10, P=0·026) and breast tenderness (F(2,32) 4·59, P=0·018), were reduced from baseline after soy IF, but not milk protein placebo. Cramps (F(2,32) 4·15, P=0·025) and swelling (F(2,32) 4·64, P=0·017) were significantly lower after active treatment compared with placebo. Concentrations of genistein and daidzein were increased following soy IF consumption, but equol production did not enhance symptom reduction. The present study showed that ISP containing IF may have potential to reduce specific premenstrual symptoms via non-classical actions.

Keywords

Phyto-oestrogenPMSNutrientMenstrualHormoneSoy
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 5 , May 2005 , pp. 731 - 739
Copyright
Copyright © The Nutrition Society 2005

References

Ashby, CR, Carr, LA, Cook, CL & Steptoe, MM (1988) Alteration of platelet serotonergic mechanisms and monoamine oxidase activity in premenstrual syndrome. Biol Psychiatry 24, 225–233.CrossRefGoogle ScholarPubMed
Brienholt, V & Larsen, JP (1998) Detection of weak estrogenic flavonoids using a recombinant yeast strain and a modified MCF7 cell profileration assay. Chem Res Toxicol 11, 622–629.CrossRefGoogle Scholar
Bryant, M & Dye, L (2004) Nutrient interventions for Premenstrual Syndrome (PMS): a review of the evidence for their efficacy. Curr Topics Nutraceutical Res 2, 201–219.Google Scholar
Burke, BE, Olson, RD & Cusack, BJ (2002) Randomized, controlled trial of phytoestrogen in the prophylactic treatment of menstrual migraine. Biomed Pharmacother 56, 283–288.Google Scholar
Cassidy, A, Bingham, S & Setchell, KD (1994) Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr 60, 333–340.CrossRefGoogle Scholar
Cassidy, A, Bingham, S & Setchell, K (1995) Biological effects of isoflavones in young women: importance of the chemical composition of soyabean products. Br J Nutr 74, 587–601.CrossRefGoogle ScholarPubMed
Cassidy, A & Foughnan, M (2000) Phyto-oestrogens throughout the life cycle. Proc Nutr Soc 59, 489–496.Google Scholar
Cohen, J & Cohen, P (1983) Applied Multiple Regression/Correlation Analysis for Behavioural Sciences. Hillsdale: Erlbaum.Google Scholar
Freeman, E, DeRubeis, R & Rickels, K (1996) Reliability and validity of a daily diary for premenstrual syndrome. Psychiatry Res 62, 97–106.Google Scholar
Freeman, EW (2003) Premenstrual syndrome and premenstrual dysphoric disorder: definitions and diagnosis. Psychoneuroendocrinology 28, 25–37.CrossRefGoogle Scholar
Freeman, EW & Rickels, K (1999) Characteristics of placebo responses in medical treatment of premenstrual syndrome. Arch Gen Psychiatry 156, 1403–1408.Google Scholar
Halbreich, U (2003) The etiology, biology, and evolving pathology of premenstrual syndromes. Psychoneuroendocrinology 28, 55–99.CrossRefGoogle ScholarPubMed
Hill, CE & Dye, L (2003) Phytoestrogens and cognitive performance: a review of the evidence. Curr Topics Nutraceutical Res 1, 203–212.Google Scholar
Ingram, DM, Hickling, C, West, L, Mahe, LJ & Dunbar, PM (2002) A double-blind randomized controlled trial of isoflavones in the treatment of cyclical mastalgia. The Breast 11, 170–174.Google Scholar
Ishiwata, N, Uesugi, S, Uehara, M & Watanabe, S (2005) Effects of soy isoflavones on premenstrual syndrome. Proceedings of the International Soy and Health Conference. Br J Nutr (In the Press).Google Scholar
Korzekwa, MI & Steiner, M (1999) Assessment and treatment of premenstrual syndromes. Prim Care Update Ob Gyns 6, 153–162.Google Scholar
Kuiper, GG, Enmark, E, Pelto-Huikkp, M, Nilsson, S & Gustafasson, JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93, 5925–5930.Google Scholar
Kurzer, MS (2002) Hormonal effects of soy in premenstrual women and men. J Nutr 132 570S – 573SCrossRefGoogle Scholar
Lephart, ED, Galindo, E & Bu, LH (2003) Stress (hypothalamic–pituitary–adrenal axis) and pain response in male rats exposed lifelong to high vs. low phytoestrogen diets. Neurosci Lett 342, 65–68.CrossRefGoogle ScholarPubMed
Lephart, ED, West, TW, Weber, SW, Rhees, R, Setchell, K, Aldercreutz, H & Lund, T (2001) Neurobehavioural effects of dietary soy phytoestrogens. Neurotoxicol Teratol 24, 5–16.CrossRefGoogle Scholar
Mallett, AK & Rowland, IR (1988) Factors affecting the gut microflora. In Role of the Gut Flora in Toxicity and Cancer, pp.347 – 382 [Rowland, IR, editors]. London: Academic Press.Google Scholar
Maskarinec, G, Franke, AA, Williams, AE, Hebshi, S, Oshiro, C, Murphy, S & Stanczyk, FZ (2004) Effects of a 2-year randomized soy intervention on sex hormone in premenstrual women. Cancer Epidemiol Biomarkers Prev 13, 1736–1744.CrossRefGoogle Scholar
McFadyen, IJ, Chetty, U, Setchell, KDR, Zimmer-Nechemias, L, Stanley, E & Miller, WR (2000) A randomized double blind–cross over trial of soya protein for the treatment of cyclical breast pain. Breast 9, 271–276.CrossRefGoogle ScholarPubMed
Mortola, JF (1992) Issues in the diagnosis and research of premenstrual syndrome. Clin Obstet Gyn 35, 587–597.Google Scholar
Mortola, JF (1996) Premenstrual Syndrome. Trends Endocrinol Metab 7, 184–189.Google Scholar
Muse, KN, Cetel, NS, Futterman, LA & Yen, SSC (1984) The premenstrual syndrome: effects of ‘medical ovariectomy’. N Engl J Med 311, 1345–1349.CrossRefGoogle ScholarPubMed
National Institute of Mental Health (1983) NIMH Premenstrual Syndrome Workshop Guidelines. Rockville, MD: National Institute of Mental HealthGoogle Scholar
Pearlstein, T & Steiner, M (2000) Non-antidepressant treatment of premenstrual syndrome. J Clin Psychiatry 61, 22–27.Google ScholarPubMed
Reid, RL & Yen, SSC (1981) The effect of [beta]-endorphin on arginine-induced growth hormone and prolactin release. Life Sci 29, 2641–2647.Google Scholar
Rowland, IR, Faughnan, M, Hoey, L, Wahala, K, Williamson, G & Cassidy, A (2003) Bioavailability of phyto-oestrogens. Br J Nutr 89, S34–S58.CrossRefGoogle ScholarPubMed
Rowland, IR, Wiseman, H, Sanders, TA, Adlercreutz, H & Bowey, EA (2000) Interindividual variation in metabolism of soy isoflavones and lignans: influence of habitual diet on equol production by the gut microflora. Nutr Cancer 36, 27–32.CrossRefGoogle ScholarPubMed
Rubinow, DR (1992) The Premenstrual Syndrome: new views. J Am Med Assoc 268, 1908–1912.CrossRefGoogle ScholarPubMed
Rubinow, DR & Schmidt, PJ (1995) The treatment of Premenstrual Syndrome – forward into the past. N Engl J Med 332, 1574–1575.Google Scholar
Schnurr, PP (1989) Measuring amount of symptom change in the diagnosis of premenstrual syndrome. J Consult Clin Psychol 1, 227–283.Google Scholar
Setchell, K, Brown, N & Lydeking-Olsen, (2002) The clinical importance of the metabolite equol – a clue to the effectiveness of soy and its isoflavones. J Nutr 132, 3577–3584.Google Scholar
Setchell, K & Cassidy, A (1999) Dietary isoflavones: biological effects and relevance to human health. J Nutr 129, 758–767.CrossRefGoogle ScholarPubMed
Setchell, KD, Borriello, SP, Hulme, P, Kirk, DN & Axelson, M (1984) Nonsteroidal estrogens of dietary origin: possible roles in hormone-dependent disease. Am J Clin Nutr 40, 569–578.CrossRefGoogle ScholarPubMed
Singh, B, Berman, B, Simpson, R & Annechild, A (1998) Incidence of premenstrual syndrome and remedy usage: a national probability sample study. Altern Ther Health Med 4, 75–79.Google Scholar
Steiner, M, Coote, M, Wilkins, A & Dunn, E (1997) Biological correlates of irritability in women with premenstrual dysphoria. Euro Neuropsychopharmacol 7 S172CrossRefGoogle Scholar
Tabachnick, BG & Fidell, LS (1996) Using Multivariate Statistics, 3rd ed. New York: Harper Collins.Google Scholar
VanStrien, T, Frijters, J, Bergers, G & Defares, P (1986) The Dutch Eating Behavior Questionnaire (DEBQ) for assessment of restrained, emotional and external eating behavior. Int J Eat Disord 5, 295–315.3.0.CO;2-T>CrossRefGoogle Scholar
Walker, A (1995) Theory and methodology in premenstrual syndrome research. Soc Sci Med 41, 793–800.Google Scholar
Wu, AH, Stanczyk, FZ, Hendrich, S, Murphy, PA, Zhang, C, Wan, P & Pike, MC (2000) Effects of soy foods on ovarian function in premenopausal women. Br J Cancer 82, 1879–1886.CrossRefGoogle ScholarPubMed
Xu, X, Duncan, AM, Merz, BE & Kurzer, MS (1998) Effects of soy isoflavones on estrogen and phytoestrogen metabolism in premenopausal women. Cancer Epidemiol Biomarkers Prev 7, 1101–1108.Google ScholarPubMed