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The effect of acid peptic digestion on free and tissue-bound cobalamins

Published online by Cambridge University Press:  09 March 2007

J. F. Adams ,
Elizabeth H. Kennedy ,
J. Thomson  and
J. Williamson
J. F. Adams
Affiliation:
Southern General Hospital, Glasgow
Elizabeth H. Kennedy
Affiliation:
Southern General Hospital, Glasgow
J. Thomson
Affiliation:
Southern General Hospital, Glasgow
J. Williamson
Affiliation:
Southern General Hospital, Glasgow
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Abstract

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1. The extent of liberation of radioactive cobalamin in rabbit tissues incubated with acid and pepsin was evaluated by bag dialysis.

2. Between a half and two-thirds of the cobalamin—probably hydroxocobalamin—was dialysable after acid pepsin treatment and this process may be a factor in the absorption of cobalamins from foods.

3. Studies of pure cobalamin solutions at different concentrations gave apparently anomalous results, which may have been due to the adherence of cobalamin to the dialysis membrane. Measurement of the amount adherent to the membrane is an important factor in dialysis studies with cobalamins.

Type
Research Article
Information
British Journal of Nutrition , Volume 22 , Issue 1 , February 1968 , pp. 111 - 114
Copyright
Copyright © The Nutrition Society 1968

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