Hostname: page-component-cd9895bd7-dk4vv Total loading time: 0 Render date: 2024-12-18T15:42:33.780Z Has data issue: false hasContentIssue false
  • English
  • Français

Effect of acetic acid feeding on the circadian changes in glycogen and metabolites of glucose and lipid in liver and skeletal muscle of rats

Published online by Cambridge University Press:  08 March 2007

Takashi Fushimi  and
Yuzo Sato
Takashi Fushimi*
Affiliation:
Central Research Institute, Mizkan Group Corporation, 2–6 Nakamura-cho, Handa Aichi 475-8585, Japan
Yuzo Sato
Affiliation:
Department of Health Science, Faculty of Psychological and Physical Sciences, Aichi Gakuin University, Nisshin, Japan
*
*Corresponding author: Dr Takashi Fushimi, fax +81 569 24 5028, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The aim of the present study is to investigate the effect of acetic acid feeding on the circadian changes in glycogen concentration in liver and skeletal muscle. Rats were provided meal once daily (09.00–13.00 hours) for 10d. On the 11th day, they were either killed immediately or given 9g diet containing either 0 (control) or 0·7g/kg-diet acetic acid beginning at 09.00 hours for 4h, as in the previous regimen. Rats in the fed group were killed at 4, 8 or 24h after the start of feeding. At 4h after the start of feeding, the acetic acid group had significantly greater liver and gastrocnemius muscle glycogen concentrations (P<0·05). Also, at this same point, liver xylulose-5-phosphate, a key stimulator of glycolysis, the ratio of fructose-1,6-bisphosphate to fructose-6-phosphate in skeletal muscle, which reflects phosphofructokinase-1 activity, and liver malonyl-CoA, an allosteric inhibitor of carnitine palmitoyl-transferase, were significantly lower in the acetic acid group than in the control group (P<0·05). In addition, the acetic acid group had a significantly lower serum lactate concentration and lower ratio of insulin to glucagon than the control group at the same point (P<0·05). We conclude that a diet containing acetic acid may enhance glycogen repletion but not induce supercompensation, a large increase in the glycogen level that is beneficial in improving performance, in liver and skeletal muscle by transitory inhibition of glycolysis. Further, we indicate the possibility of a transient enhancement of fatty acid oxidation in liver by acetic acid feeding.

Keywords

Acetic acidGlycogen repletionGlycolysisFatty acid oxidation
Type
Research Article
Information
British Journal of Nutrition , Volume 94 , Issue 5 , November 2005 , pp. 714 - 719
Copyright
Copyright © The Nutrition Society 2005

References

Carnona, A, Mishima, PT, Avery, EH & Freedland, RA (1991) Time course changes in glycogen accretion, 6-phosphogluconate, fructose-2,6-bisphosphate, and lipogenesis upon refeeding a high sucrose diet to starved rats. Int J Biochem 23, 455–460.Google Scholar
Casazza, JP & Veech, RL (1986) The measurement of xylulose 5-phosphate, ribulose 5-phosphate, and combined sedoheptulose 7-phosphate and ribose 5-phosphate in liver tissue. Anal Biochem 159, 243–248.CrossRefGoogle ScholarPubMed
Chang, C, Ohshima, T & Koizumi, C (1994) Changes in the composition of free amino acids, organic acids and lipids during processing and ripening of ‘Hatahata-zushi', a fermented fish product of sandfish (Arctoscopus japonicus). J Sci Food Agric 66, 75–82.Google Scholar
Claus, TH, El-Maghrabi, MR, Regen, DM, Stewart, HB, McGrane, M, Kountz, PD, Nyfeles, F, Pilkis, J & Pilkis, SJ (1984) The role of fructose 2,6-bisphosphate in the regulation of carbohydrate metabolism. Curr Top Cell Regul 23, 57–86.CrossRefGoogle ScholarPubMed
Dagley, S (1974) Citrate UV spectrophotometric determination. In Methods of Enzymatic Analysis, pp. 1562–1565 [Bergmeyel, Ho, editor]. New York: Academic Press.Google Scholar
DeBuysere, MS & Olson, MS (1983) The analysis of acetyl-coenzyme A derivatives by reverse-phase high-performance liquid chromatography. Anal Biochem 133, 373–379.Google Scholar
El-Maghrabi, MR, Claus, TH, Piliks, J, Fox, E & Piliks, SJ (1982) Regulation of rat liver fructose 2,6-bisphosphatase. J Biol Chem 257, 7603–7607.Google Scholar
Fujii, T, Sasaki, T & Okuzumi, M (1992) Chemical composition and microbial flora of saba-narezushi (fermented mackerel with rice) (in Japanese). Nippon Suisan Gakkaishi 58, 891–894.CrossRefGoogle Scholar
Fushimi, T, Tayama, K, Fukaya, M, Kitakoshi, K, Nakai, N, Tsukamoto, Y & Sato, Y (2001) Acetic acid feeding enhances glycogen repletion in liver and skeletal muscle of rats. J Nutr 131, 1973–1977.Google Scholar
Fushimi, T, Tayama, K, Fukaya, M, Kitakoshi, K, Nakai, N, Tsukamoto, Y & Sato, Y (2002) The efficacy of acetic acid for glycogen repletion in rat skeletal muscle after exercise. Int J Sports Med 23, 218–222.CrossRefGoogle ScholarPubMed
Hers, HG & Van Schaftingen, E (1984) Protein phosphorylation in the control of glycolysis and gluconeogenesis in the liver. Adv Cyclic Nucleotide Protein Phosphorylation Res 17, 343–349.Google ScholarPubMed
Holloszy, JO, Kohrt, WM & Hansen, PA (1998) The regulation of carbohydrate and fat metabolism during and after exercise. Front Biosci 3, D1011–D1027.Google Scholar
Holness, MJ, Schuster-Bruce, MJ & Sugden, MC (1988) Skeletal-muscle glycogen synthesis during the starved-to-fed transition in the rat. Biochem J 254, 855–859.Google Scholar
Hue, L, Sorbino, F & Bosca, L (1984) Difference in glucose sensitivity of liver glycolysis and glycogen synthesis. Biochem J 224, 779–786.Google Scholar
Kasamatsu, T, Yoshimura, N, Morioka, S & Hashimoto, T (1996) Relationship of the number of consumed food items with nutritional status and obesity (in Japanese). Eiyougakuzasshi 54, 19–26.CrossRefGoogle Scholar
Kawaguchi, T, Osatomi, K, Yamashita, H, Kabashima, T & Uyeda, K (2002) Mechanism for fatty acid ‘sparing’ effect on glucose-induced transcription. J Biol Chem 277, 3829–3835.Google Scholar
Kuwajima, M, Newgard, CB, Foster, DW & McGarry, JD (1984) Time course and significance of changes in hepatic fructose-2,6-bisphosphate levels during refeeding of fasted rats. J Clin Invest 74, 1108–1111.Google Scholar
Liu, YQ & Uyeda, K (1996) A mechanism for fatty acid inhibition of glucose utilization in liver. J Biol Chem 271, 8824–8830.CrossRefGoogle ScholarPubMed
Lo, S, Russell, JC & Taylor, AW (1970) Determination of glycogen in small tissue samples. J Appl Physiol 28, 234–236.CrossRefGoogle ScholarPubMed
Lowry, OH & Passonneau, JV (editors) (1972) A collection of metabolite analysis. In A Flexible System of Enzymatic Analysis, pp. 146–218.Google Scholar
McGarry, JD & Brown, NF (1997) The mitochondrial carnitine palmitoyltransferase system. From concept to molecular analysis. Eur J Biochem 244, 1–14.CrossRefGoogle ScholarPubMed
McGarry, JD, Kuwajima, M, Newgard, CB & Foster, DW (1987) From dietary glucose to liver glycogen: the full circle round. Ann Rev Nutr 7, 51–73.CrossRefGoogle ScholarPubMed
Mine, H, Yamagami, Y & Ohno, N (1982) Studies in food seasoning (part 3) ‘Takikomi-zushi’ (in Japanese). Rep Res Matsuyama Shinonome Jr Coll 13, 81–88.Google Scholar
Murase, M, Kimura, Y & Nagata, Y (1995) Determination of portal short-chain fatty acids in rats fed various dietary fibers by capillary gas chromatography. J Chromatogr B 664, 415–420.CrossRefGoogle ScholarPubMed
Nishimura, M & Uyeda, K (1995) Purification and characterization of a novel xylulose 5-phosphate-activated protein phosphatase catalyzing dephosphorylation of fructose-6-phosphate,2-kinase:fructose-2,6-bisphosphatase. J Biol Chem 270, 26341–26346.Google Scholar
Okuda, K & Hayashi, K (1994) Validity and limit of dietary guideline ‘try to take 30 kinds of food a day’ (in Japanese). Konan Women's Univ Kennkyu Kiyo 31, 255–266.Google Scholar
Passonneau, JV & Lowry, OH (editors) (1993) Glycogen synthase. In Enzymatic Analysis: A Practical Guide, pp. 268–269. Totowa, NJ: Humana Press.Google Scholar
Pomare, EW, Branch, WJ & Cummings, JH (1985) Carbohydrate fermentation in the human colon and its relation to acetate concentrations in venous blood. J Clin Invest 75, 1448–1454.CrossRefGoogle ScholarPubMed
Ren, H, Endo, H, Watanabe, E & Hayashi, T (1997) Chemical and sensory characteristics of Chinese, Korean and Japanese vinegars. J Tokyo Univ Fisheries 84, 1–11.Google Scholar
Rodger, G, Hastings, R, Cryne, C & Bailey, J (1984) Diffusion properties of salt and acetic acid into herring and their subsequent effect on the muscle tissue. J Food Sci 49, 714–720.Google Scholar
Ross, BD & Krebs, HA (1967) Carbohydrate metabolism of the perfused rat liver. Biochem J 105, 869–875.Google Scholar
Seitz, HJ, Müller, MJ & Nordmeyer, P (1976) Concentration of cyclic AMP in rat liver as a function of the insulin/glucagon ratio in blood under standardized physiological conditions. Endocrinology 99, 1313–1318.Google Scholar
Seus, I & Martin, M (1993) The influence of marinating with food acids on the composition and sensory properties of beef. Fleischwirtsch 73, 292–295.Google Scholar
Shimbo, S, Kimura, K, Imai, Y, Yasumoto, M, Yamamoto, K, Watanabe, T, Iwami, O, Ikeda, M & Nakatsuka, H (1994) Number of food items as an indicator of nutrient intake. Ecol Food Nutr 32, 197–206.Google Scholar
Struck, E & Ashmore, J (1966) Wieland O Effects of glucagons and long chain fatty acids on glucose production by isolated perfused rat liver. Adv Enzyme Regul 4, 219–224.Google Scholar
Uyeda, K, Furuya, E & Richards, CS (1982) Yokoyama M Fructose-2,6-P2, chemistry and biological function. Mol Cell Biochem 48, 97–120.Google Scholar
Wakelam, MJO & Pette, D (1982) The control of glucose 1,6-phosphate by developmental state and hormonal stimulation in culutured muscle tissue. Biochem J 204, 765–769.Google Scholar
Williamson, JR & Krebs, HA (1961) Acetoacetate as fuel of respiration in the perfused rat heart. Biochem J 80, 540–547.CrossRefGoogle ScholarPubMed
Winder, WW & Hardie, DG (1999) AMP-activated protein kinase, a metabolic master switch: possible roles in Type 2 diabetes. Am J Physiol 277, E1–E10.Google Scholar