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Dose-dependent effect of capsaicin on endurance capacity in rats

Published online by Cambridge University Press:  09 March 2007

Tae-Woong Oh  and
Fukio Ohta
Tae-Woong Oh*
Affiliation:
Department of Sports Sciences, School of Human Sciences, Waseda University, Japan
Fukio Ohta
Affiliation:
Department of Sports Sciences, School of Human Sciences, Waseda University, Japan
*
*Corresponding author:Dr Tae-Woong Oh, fax +81 (42) 947 6808, email [email protected]
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Abstract

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The present study was designed to determine the effects of various levels of capsaicin (CAP) on endurance capacity in forty-nine male Sprague–Dawley rats, aged 4 weeks, which were assigned to four groups. Rats were given orally either control (0) or 6, 10 or 15 mg CAP/kg body weight 2 h before exercise by stomach intubations using a round-ended needle. The rats in each group were divided into two subgroups for resting or swimming exercise. Swimming exercise was performed with a weight corresponding to 3 % body weight attached to the tail, and endurance capacity was evaluated by swimming time to exhaustion. The highest dose (15 mg/kg) of CAP significantly (P < 0·05) increased endurance performance time and caused plasma non-esterified fatty acid to rise significantly by about 1·4-fold compared with that of non-CAP treated rats at exhaustion (P < 0·05). The highest dose of CAP had no effect on liver and gastrocnemius muscle glycogen (white and red) in resting rats, but significantly increased glycogen contents of both muscles at exhaustion (P < 0·05). At rest, plasma noradrenalin levels of the rats receiving the highest dose were greater than that of non-CAP-treated rats and remained greater until exhaustion. The effects of CAP on endurance capacity have received little attention and have conveyed conflicting impressions. Kim et al. (1997) failed to show the maximal effect of 10 mg/kg doses of CAP on swimming endurance time in mice. The influences of various doses of CAP on endurance capacity were still unclear. Matsuo et al. (1996) reported that the intake of CAP have little sparing effect on glycogen in the liver and soleus muscles at rest and during exercise in rats previously fed a CAP-containing diet ad libitum for 1 week. Our present results suggest more than the highest dose of CAP (15 mg/kg) can cause the increase of endurance capacity, which might be induced through the sparing of muscle glycogen and the rise of non-esterfied fatty acids following the increase of circulating catecholamine.

Keywords

CapsaicinCatecholamineSwimmingEndurance capacityNon-esterified fatty acid
Type
Research Article
Information
British Journal of Nutrition , Volume 90 , Issue 3 , September 2003 , pp. 515 - 520
Copyright
Copyright © The Nutrition Society 2003

References

Azevedo, JL, Linderman, JK, Lehman, SL & Brooks, GA (1998) Training decreases muscle glycogen turnover during exercise. Eur J Appl Physiol 78, 479–486.CrossRefGoogle ScholarPubMed
Conlee, RK, Rennie, MJ & Winder, WW (1976) Skeletal muscle glycogen content: diurnal variation and effects of fasting. Am J Physiol 231, 614–618.CrossRefGoogle ScholarPubMed
Costill, DL, Dalsky, GP & Fink, WJ (1978) Effects of caffeine ingestion on metabolism and exercise performance. Med Sci Sports 10, 155–158.Google ScholarPubMed
Dawson, CA & Horvath, SM (1970) Swimming in small laboratory animals. Med Sci Sports Exerc 2, 51–78.CrossRefGoogle ScholarPubMed
Graham, TE & Spriet, LL (1991) Performance and metabolic responses to a high caffeine dose during prolonged exercise. J Appl Physiol 71, 2292–2298.CrossRefGoogle ScholarPubMed
Issekutz, B & Vranic, M (1980) Role of glucagons in regulation of glucose production in exercising dogs. Am J Physiol 238, E13–E20.Google ScholarPubMed
Ivy, JL, Costill, DL, Fink, WJ & Lower, RW (1979) Influence of caffeine and carbohydrate feeding on endurance performance. Med Sci Sports 11, 6–11.CrossRefGoogle ScholarPubMed
Kawada, T, Watanabe, T, Takaishi, T, Tanaka, T & Iwai, K (1986) Capsaicin-induced beta-adrenergic, action on, energy metabolism in, rats: influence of, capsaicin on, oxygen consumption, the respiratory, quotient, and substrate utilization. Exp Biol Med 183, 250–256.CrossRefGoogle ScholarPubMed
Kim, KM, Kawada, T, Ishihara, K, Inoue, K & Fushiki, T (1997) Increase in swimming endurance capacity of mice by capsaicin-induced adrenal catecholamine secretion. Biosci Biotechnol Biochem 61, 1718–1723.CrossRefGoogle Scholar
Klein, S, Coyle, EF & Wolfe, RR (1993) Fat metabolism during low-intensity exercise in endurance-trained and untrained men. Am J Physiol 267, E934–E940.Google Scholar
Leighton, B & Foot, EA (1995) The role of the sensory peptide calcitonin-gene-related peptide(s) in skeletal muscle carbohydrate metabolism: effects of capsaicin and resiniferatoxin. Biochem J 307, 707–712.CrossRefGoogle ScholarPubMed
Lim, K, Yoshioka, M, Kikuzato, S, et al. (1997) Dietary red pepper ingestion increases carbohydrate oxidation at rest and during exercise in runners. Med Sci Sports Exerc 29, 355–361.CrossRefGoogle ScholarPubMed
Lo, SJ, Russell, C & Taylor, AW (1970) Determination of glycogen in small tissue samples. J Appl Physiol 28, 234–236.CrossRefGoogle ScholarPubMed
Matsuo, T, Yoshioka, M & Suzuki, M (1996) Capsaicin in diet does not affect glycogen contents in the liver and skeletal muscle of rats before and after exercise. J Nutr Sci Vitaminol (Tokyo) 42, 249–256.CrossRefGoogle Scholar
Oh, TW (2001) Effects of capsaicin administration on brown adipose tissue oxygen consumption in Wistar–Kyoto and spontaneously hypertensive rat. Hum Sci Res 10, 229–239.Google Scholar
Wachtel, RE (1999) Capsaicin. Reg Anesth Pain Med 24, 361–363.CrossRefGoogle ScholarPubMed
Wasserman, DH, Lavina, H, Lickley, A & Vranic, M (1984) Interactions between glucagons and other counterregulatory hormones during normoglycemic and hypoglycemic exercise in dogs. J Clin Invest 74, 1404–1473.CrossRefGoogle ScholarPubMed
Wasserman, DH, Spalding, JA, Lacy, DB, Colburn, CA, Goldstein, RE & Cherrington, AD (1989 a) Glucagon is a primary controller of hepatic glycogenolysis and gluconeogenesis during muscular work. Am J Physiol 257, E108–E117.Google ScholarPubMed
Wasserman, DH, Williams, PE, Lacy, DB, Goldstein, RE & Cherrington, AD (1989 b) Exercise-induced fall in insulin and hepatic carbohydrate metabolism during muscular work. Am J Physiol 256, E500–E509.Google ScholarPubMed
Winder, WW (1986) Effect of intravenous caffeine on liver glycogenolysis during prolonged exercise. Med Sci Sports Exerc 18, 192–196.CrossRefGoogle ScholarPubMed
Wolfe, RR, Nadel, ER, Shaw, JHF, Stephenson, LA & Wolfe, MH (1986) Role of changes in insulin and glucagons in glucose homeostasis in exercise. J Clin Invest 77, 900–907.CrossRefGoogle ScholarPubMed