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Dietary treatment of thrombogenic disorders related tothe metabolic syndrome

Published online by Cambridge University Press:  09 March 2007

Peter Marckmann
Peter Marckmann*
Affiliation:
Research Department of Human Nutrition, The Royal Veterinary and Agricultural University, Rolighedsvej 30, DK-1958, Frederiksberg C, Denmark
*
*Corresponding author: P. Marckmann, fax +45 3528 2483, email [email protected]
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Abstract

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The increased risk of coronary heart disease associated with the metabolic syndrome may be partially explained by prothrombotic deviations of the haemostatic system. Individuals with insulin resistance, dyslipidaemia and obesity are characterized by elevated plasma fibrinogen and factor VII coagulant activity levels and raised concentrations of plasminogen-activator inhibitor, the main inhibitor of endogenous fibrinolysis. These haemostatic abnormalities may be corrected with dietary treatment of the underlying clinical disorder. Dietary trials of diseased and healthy volunteers suggest that the optimal antithrombotic diet is a low-fat diet with a high content of foods rich in complex carbohydrates and dietary fibre. The dietary fatty acid composition has a profound effect on blood lipids, but seems of minor importance for the haemostatic system.

Keywords

Coronary heart diseaseFactor VIIFibrinolysisDietLipids: Dietary fibre
Type
Research Article
Information
British Journal of Nutrition , Volume 83 , Issue S1 , June 2000 , pp. S121 - S126
Copyright
Copyright © The Nutrition Society 2000

References

Almendingen, K, Seljeflot, I, Sandstad, B, Pedersen, JI (1996) Effects of partially hydrogenated fish oil, partially hydrogenated soybean oil, and butter on hemostatic variables in men. Arteriosclerosis, Thrombosis and Vascular Biology 16, 375–380.CrossRefGoogle ScholarPubMed
Allman-Farinelli, MA, Hall, D, Kingham, K, Pang, D, Petocz, P, Favalaro, EJ (1999) Comparison of the effects of two low fat diets with different α-linolenic: linoleic acid ratios on coagulation and fibrinolysis. Atherosclerosis 142, 159–168.CrossRefGoogle ScholarPubMed
Astrup, T (1958) The haemostatic balance. Thrombosis et Diathesis Haemorrhagica 2, 347–357.Google ScholarPubMed
Avellone, G, Garbo, VD, Cordova, R, Scaffidi, L, Bompiani, GD (1998) Effects of mediterranean diet on lipid, coagulative and fibrinolytic parameters in two randomly selected population samples in Western Sicily. Nutrition, Metabolism and Cardiovascular Diseases 8, 287–296.Google Scholar
Brace, LD, Gittler-Buffa, C, Miller, GJ, Cole, TG, Schmeisser, D, Prewitt, TE, Bowen, PE (1994) Factor VII coagulant activity and cholesterol changes in premenopausal women consuming a long-term cholesterol-lowering diet. Arteriosclerosis and Thrombosis 14, 1284–1289.CrossRefGoogle ScholarPubMed
Charles, MA, Morange, P, Eschwege, E, André, P, Vague, P, Juhan-Vague, I (1998) Effect of weight change and metformin on fibrinolysis and the von Willebrand factor in obese nondiabetic subjects. Diabetes Care 21, 1967–1972.CrossRefGoogle ScholarPubMed
Folsom, AR, Wu, KK, Davis, CE, Conlan, MG, Sorlie, PD, Szklo, M (1991) Population correlates of plasma fibrinogen and factor VII, putative cardiovascular risk factors. Atherosclerosis 91, 191–205.CrossRefGoogle ScholarPubMed
Folsom, AR, Qamhieh, HT, Wing, RR, Jeffery, RW, Stinson, VL, Kuller, LH, Wu, KK (1993) Impact of weight loss on plasminogen activator inhibitor (PAI-1), factor VII, and other hemostatic factors in moderately overweight adults. Arteriosclerosis and Thrombosis 13, 162–169.CrossRefGoogle ScholarPubMed
Fuster, V, Badimon, L, Badimon, JJ, Chesebro, JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes. New England Journal of Medicine 326, 212–250.Google ScholarPubMed
Fuster, V, Badimon, L, Badimon, JJ, Chesebro, JH (1992) The pathogenesis of coronary artery disease and the acute coronary syndromes. New England Journal of Medicine 326, 310–318.Google ScholarPubMed
Heinrich, J, Wahrburg, U, Martin, H, Assmann, G (1990) The effect of diets rich in mono- or polyunsaturated fatty acids on lipid metabolism and haemostasis. Fibrinolysis 4, (Suppl. 2), 76–78.CrossRefGoogle Scholar
Järvi, AE, Karlström, BE, Granfeldt, YE, Björck, IE, Asp, NGL, Vessby, B (1999) Improved glycemic control and lipid profile and normalized fibrinolytic activity on a low-glycemic index diet in type 2 diabetic patients. Diabetes Care 22, 10–18.CrossRefGoogle ScholarPubMed
Jespersen, J (1988) Pathophysiology and clinical aspects of fibrinolysis and inhibition of coagulation. Experimental and clinical studies with special to women on oral contraceptives and selected groups of thrombosis prone patients. Danish Medical Bulletin 35, 1–33.Google ScholarPubMed
Juhan-Vague, I, Alessi, MC, Vague, P (1991) Increased plasma plasminogen activator inhibitor 1 levels. A possible link between insulin resistance and atherothrombosis. Diabetologia 34, 457–462.CrossRefGoogle Scholar
Juhan-Vague, I, Thompson, SG, Jespersen, J (1993) Involvement of the hemostatic system in the insulin resistance syndrome. A study of 1500 patients with angina pectoris. Arteriosclerosis and Thrombosis 13, 1865–1873.CrossRefGoogle ScholarPubMed
Juhan-Vague, I, Alessi, MC, Vague, P (1996) Thrombogenic and fibrinolytic factors and cardiovascular risk in non-insulin-dependent diabetes mellitus. Annals of Medicine 28, 371–380.CrossRefGoogle ScholarPubMed
Larsen, LF, Bladbjerg, EM, Jespersen, J, Marckmann, P (1997) Effects of dietary fat quality and quantity on postprandial activation of blood coagulation factor VII. Arteriosclerosis, Thrombosis and Vascular Biology 17, 2904–2909.CrossRefGoogle ScholarPubMed
Larsen, LF, Jespersen, J, Marckmann, P (1999) Are olive oil diets antithrombotic? Diets enriched with either olive, rapeseed or sunflower oil affect postprandial factor VII differently. American Journal of Clinical Nutrition 70, 976–982.CrossRefGoogle ScholarPubMed
Lindahl, B, Nilsson, TK, Asplund, K, Hallmans, G (1998) Intense nonpharmacological intervention in subjects with multiple cardiovascular risk factors: decreased insulin levels but only a minor effect on plasma plasminogen activator inhibitor activity. Metabolism 47, 384–390.CrossRefGoogle Scholar
Lindahl, B, Nilsson, TK, Jansson, JH, Asplund, K, Hallmans, G (1999) Improved fibrinolysis by intense lifestyle intervention. A randomized trial in subjects with impaired glucose tolerance. Journal of Internal Medicine 246, 105–112.CrossRefGoogle ScholarPubMed
Marckmann, P (1995) Diet, blood coagulation and fibrinolysis. Danish Medical Bulletin 42, 410–425.Google ScholarPubMed
Marckmann, P &, Jespersen, J (1996) Low-fat/high-fiber diets and coagulation/fibrinolysis. In Nutrition, Genetics, and Heart Disease, pp. 50–61 [G, Bray, DH, Ryan, editors]. Baton Rouge, LA: Louisiana State University Press.Google Scholar
Marckmann, P, Sandström, B, Jespersen, J (1992) The variability of and associations between measures of blood coagulation, fibrinolysis and blood lipids. Atherosclerosis 96, 235–244.CrossRefGoogle ScholarPubMed
Marckmann, P, Sandström, B, Jespersen, J (1992) Fasting blood coagulation and fibrinolysis of young healthy adults unchanged by reduction in dietary fat content. Arteriosclerosis and Thrombosis 12, 201–205.CrossRefGoogle ScholarPubMed
Marckmann, P, Sandström, B &, Jespersen, J (1992 c) Dietary n-3 and n-6 polyunsaturated fatty acids affect the fibrinolytic system differently. In Essential Fatty Acids and Eicosanoids, pp. 325–329 [Sinclair, A, Gibson, RE, editors]. Champaign, IL: American Oil Chemists' Society.Google Scholar
Marckmann, P, Sandström, B, Jespersen, J (1993) Favorable long-term effect of a low-fat/high-fiber diet on human blood coagulation and fibrinolysis. Arteriosclerosis and Thrombosis 13, 505–511.CrossRefGoogle ScholarPubMed
Marckmann, P, Sandström, B, Jespersen, J (1994) Low-fat high-fiber diet favorably affects several independent risk markers of ischemic heart disease. Observations on blood lipids, coagulation, and fibrinolysis from a trial of middle-aged Danes. American Journal of Clinical Nutrition 59, 935–939.CrossRefGoogle ScholarPubMed
Marckmann, P, Bladbjerg, EM, Jespersen, J (1997) Dietary fish oil (4 g daily) and cardiovascular risk markers in healthy men. Arteriosclerosis, Thrombosis and Vascular Biology 17, 3384–3391.CrossRefGoogle ScholarPubMed
Marckmann, P, Bladbjerg, EM, Jespersen, J (1998) Diet and blood coagulation factor VII — a key protein in arterial thrombosis. European Journal of Clinical Nutrition 52, 75–84.CrossRefGoogle ScholarPubMed
Marckmann, P, Toubro, S, Astrup, A (1998) Sustained improvement in blood lipids, coagulation and fibrinolysis after major weight loss in obese subjects. European Journal of Clinical Nutrition 52, 329–333.CrossRefGoogle ScholarPubMed
Marckmann, P, Raben, A, Astrup, A (2000) Ad libitum intake of low-fat diets rich in either starchy foods or sucrose: effects on blood lipids, factor VII coagulant activity, and fibrinogen Metabolism.CrossRefGoogle Scholar
Mavri, A, Stegnar, M, Krebs, M, Sentocnik, JT, Geiger, M, Binder, BR (1999) Impact of adipose tissue on plasma plasminogen activator inhibitor-1 in dieting obese women. Arteriosclerosis, Thrombosis and Vascular Biology 19, 1582–1587.CrossRefGoogle ScholarPubMed
Meade, TW, Chakrabarti, R, Haines, AP, North, WRS, Stirling, Y (1979) Characteristics affecting fibrinolytic activity and plasma fibrinogen concentrations. British Medical Journal 1, 153–156.CrossRefGoogle ScholarPubMed
Meade, TW, Brozovic, M, Chakrabarti, R, Haines, AP, Imeson, JD, Mellows, S, Miller, GJ, North, WRS, Stirling, Y, Thompson, SG (1986) Haemostatic function and ischaemic heart disease: principal results of the Northwick Park Heart Study. Lancet ii, 533–537.CrossRefGoogle Scholar
Miller, GJ (1993) Hyperlipidemia and hypercoagulability. Progress in Lipid Research 32, 61–69.CrossRefGoogle ScholarPubMed
Miller, GJ, Martin, JC, Mitropoulos, KA, Reeves, BE, Thompson, RL, Meade, TW, Cooper, JA, Cruickshank, JK (1991) Plasma factor VII is activated by postprandial triglyceridaemia, irrespective of dietary fat composition. Atherosclerosis 86, 163–171.CrossRefGoogle ScholarPubMed
Miller, GJ, Mitropoulos, KA, Nanjee, MN, Howarth, DJ, Martin, JC, Esnouf, MP, Reeves, BEA, Miller, NE, Cooper, JA (1998) Very low activated factor VII and reduced factor VII antigen in familial abetalipoproteinaemia. Thrombosis and Haemostasis 80, 233–238.Google ScholarPubMed
Mitropoulos, KA, Miller, GJ, Watts, GF, Durrington, PN (1992) Lipolysis of triglyceride-rich lipoproteins activates coagulant factor XII: a study in familial lipoprotein-lipase deficiency. Atherosclerosis 95, 119–125.CrossRefGoogle ScholarPubMed
Mennen, L, de Maat, M, Meijer, G, Zock, P, Grobbee, D, Kok, F, Kluft, C, Schouten, E (1998) Factor VIIa response to a fat-rich meal does not depend on fatty acid composition: a randomized controlled trial. Arteriosclerosis, Thrombosis and Vascular Biology 18, 599–603.CrossRefGoogle Scholar
Mutanen, M, Aro, A (1997) Coagulation and fibrinolysis factors in healthy subjects consuming high stearic or trans fatty acid diets. Thrombosis and Haemostasis 77, 99–104.Google ScholarPubMed
Reaven, G (1988) Role of insulin resistance in human disease. Diabetes 37, 1595–1607.CrossRefGoogle ScholarPubMed
Roche, HM, Zampelas, A, Knapper, JM, Webb, D, Brooks, C, Jackson, KG, Wright, JW, Gould, B, Kafatos, A, Gibney, MJ, Williams, CM (1998) Effect of long-term olive oil dietary intervention on postprandial triacylglycerol and factor VII metabolism. American Journal of Clinical Nutrition 68, 522–560.CrossRefGoogle ScholarPubMed
Sanders, TAB, Miller, GJ, de Grassi, T, Yahia, N (1996) Post-prandial activation of coagulant factor VII by long-chain dietary fatty acids. Thrombosis and Haemostasis 76, 369–71.Google ScholarPubMed
Schmidt, E.B (1997) n-3 fatty acids and the risk of coronary heart disease. Danish Medical Bulletin 44, 1–22.Google ScholarPubMed
Simpson, HCR, Meade, TW, Stirling, Y, Mann, JI, Chakrabarti, R, Woolf, L (1983) Hypertriglyceridaemia and hypercoagulability. Lancet i, 786–789.CrossRefGoogle Scholar
Tholstrup, T, Marckmann, P, Jespersen, J, Sandström, B (1994) A fat high in stearic acid favorably affects blood lipids and factor VII coagulant activity in comparison to fats high in palmitic acid and high in myristic and lauric acid. American Journal of Clinical Nutrition 59, 371–377.CrossRefGoogle Scholar
Tholstrup, T, Marckmann, P, Hermansen, J, Hølmer, G, Sandström, B (1999) Effect of modified dairy fat on fasting and postprandial haemostatic variables in healthy young men. British Journal of Nutrition 82, 105–113.CrossRefGoogle ScholarPubMed
Thompson, SG, Kienast, J, Pyke, SDM, Haverkate, F, Van de Loo, JCW (1995) Hemostatic factors and the risk of myocardial infarction or sudden death in patients with angina pectoris. New England Journal of Medicine 332, 635–641.CrossRefGoogle ScholarPubMed