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Dietary phosphate-dependent growth is not mediated by changes in plasma phosphate concentration

Published online by Cambridge University Press:  18 November 2009

A. Landsman ,
D. Lichtstein ,
M. Bacaner  and
A. Ilani
A. Landsman
Affiliation:
Department of Physiology, The Hebrew University Hadassah Medical, Jerusalem, Israel
D. Lichtstein
Affiliation:
Department of Physiology, The Hebrew University Hadassah Medical, Jerusalem, Israel
M. Bacaner
Affiliation:
Department of Physiology, The University of Minnesota, Minneapolis, MN, USA
A. Ilani*
Affiliation:
Department of Physiology, The Hebrew University Hadassah Medical, Jerusalem, Israel
*
*Corresponding author: Dr A. Ilani, fax +972 2 643 9736, email [email protected]
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Abstract

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The present study was undertaken in order to assess the role of dietary phosphate in growth. A diet deficient in phosphate led to a suppression of growth in juvenile rats. The phenomenon is similar to that described for diets deficient in other essential single components such as Mg, Zn or K. However, unlike the other constituents, dietary phosphate restriction affected the growth rate much more than it altered the serum phosphate concentration; addition of phosphate to the drinking water of rats fed a low-phosphate diet restored the growth rate without a concomitant change in serum phosphate concentration. The suppression of growth rate by the deletion of phosphate was associated with a delayed decrease in food intake. This finding implies that the variation in appetite was secondary to the change in growth. The increase in body weight following phosphate supplementation was associated with a concomitant increment in food intake. The phosphate-dependent growth was, however, evident also in rats that were pair-fed with those that were not supplied with phosphate. It is concluded that dietary phosphate-dependent growth is not mediated by changes in phosphate concentrations in the extracellular fluid. It is plausible that signals arising from receptors for phosphate in the digestive system constitute part of the growth control apparatus in rats.

Keywords

Dietary phosphateLow phosphate dietGrowthIntestinal signalsAppetiteFood intake
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 2 , August 2001 , pp. 217 - 223
Copyright
Copyright © The Nutrition Society 2001

References

Ames, BN (1966) Assay for inorganic phosphate, total phosphate and phosphatases. Methods in Enzymology 8, 115–118.CrossRefGoogle Scholar
Carey, RM (1978) Evidence for a splanchnic sodium input monitor regulating renal sodium excretion in man. Circulation Research 43, 19–23.Google Scholar
Caverzasio, J & Bonjour, JP (1985) Mechanism of rapid phosphate (Pi) transport adaptation to a single low Pi meal in rat renal brush border membrane. Pflugers Archiv 404, 227–231.Google Scholar
Creutzfeldt, W (1980) Insulinotropic factors of the gut; the broadening incretin concept. Gastroenterology 78, 1631–1632.CrossRefGoogle ScholarPubMed
Dorup, I, Flyvbjerg, A, Everts, ME & Clausen, T (1991) Role of insulin-like growth factor-1 and growth hormone in growth inhibition induced by magnesium and zinc deficiencies. British Journal of Nutrition 66, 505–521.CrossRefGoogle ScholarPubMed
Ebert, R & Creutzfeldt, W (1987) Gastrointestinal peptides and insulin secretion. Diabetes Metabolism Reviews 3, 1–26.CrossRefGoogle ScholarPubMed
Flyvbjerg, A, Marshall, SM, Frystyk, J, Rasch, R, Bornfeldt, KE, Arnqvist, H, Jensen, PK, Pallesen, G & Orskov, H (1992) Insulin-like growth factor I in initial renal hypertrophy in potassium-depleted rats. American Journal of Physiology 262, F1023–F1031.Google Scholar
Furman, S, Lichtstein, D & Ilani, A (1997) Sodium-dependent transport of phosphate in neuronal and related cells. Biochimica et Biophysica Acta 1325, 34–40.CrossRefGoogle ScholarPubMed
Keesey, RE & Hirvonen, MD (1997) Body weight set-points: determination and adjustment. Journal of Nutrition 127 Suppl., 1875S–1883S.Google Scholar
Levi, M, Lotscher, M, Sorribas, V, Custer, M, Arar, M, Kaissling, B, Murer, H & Biber, J (1994) Cellular mechanisms of acute and chronic adaptation of rat renal P(i) transporter to alterations in dietary P(i). American Journal of Physiology 267, F900–F908.Google Scholar
McIntyre, N, Holdsworth, CD & Turner, DS (1965) Intestinal factors in the control of insulin secretion. Journal of Clinical Endocrinology 25, 1317–1324.CrossRefGoogle ScholarPubMed
Mu, JY, Hansson, GC, Bergstrom, G & Lundgren, O (1995) Renal sodium excretion after oral and intravenous sodium loading in sodium-deprived normotensive and spontaneously hypertensive rats. Acta Physiologica Scandinavica 153, 169–177.CrossRefGoogle ScholarPubMed
Muhlbauer, RC, Bonjour, JP & Fleisch, H (1987) Effects of glucagon on renal and extrarenal handling of inorganic phosphate in mice: evidence for inorganic phosphate mobilizing activity. Mineral and Electrolyte Metabolism 13, 45–50.Google ScholarPubMed
Murer, H, Werner, A, Reshkin, S, Wuarin, F & Biber, J (1991) Cellular mechanisms in proximal tubular reabsorption of inorganic phosphate. American Journal of Physiology 260, C885–C899.Google Scholar
Obika, LF, Fitzgerald, EM, Gleason, SD, Zucker, A & Schneider, EG (1981) Lack of evidence for gastrointestinal control of sodium excretion in unanesthetized rabbits. American Journal of Physiology 240, F94–F100.Google ScholarPubMed
Orentreich, N, Matias, JR, DeFelice, A & Zimmerman, JA (1993) Low methionine ingestion by rats extends life span. Journal of Nutrition 123, 269–274.Google Scholar
Roberge, JN & Brubaker, PL (1993) Regulation of intestinal proglucagon-derived peptide secretion by glucose-dependent insulinotropic peptide in a novel enteroendocrine loop. Endocrinology 133, 233–240.CrossRefGoogle Scholar
Sweeny, JM, Seibert, HE, Woda, C, Schulkin, J, Haramati, A & Mulroney, SE (1998) Evidence for induction of a phosphate appetite in juvenile rats. American Journal of Physiology 275, R1358–R1365.Google ScholarPubMed
Thorens, B & Waeber, G (1993) Glucagon like peptide-I and the control of insulin secretion in the normal and in NIDDM. Diabetes 42, 1219–1225.CrossRefGoogle ScholarPubMed
Trohler, U, Bonjour, JP & Fleisch, H (1976) Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. Journal of Clinical Investigation 57, 264–273.CrossRefGoogle Scholar