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Dietary modulation of the human gut microflora using prebiotics

Published online by Cambridge University Press:  11 January 2019

Glenn R. Gibson
Glenn R. Gibson*
Affiliation:
Microbiology Department, Institute of Food Research, Reading, UK
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Abstract

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The human colonic flora has both beneficial and pathogenic potentials with respect to host health. There is now much interest in manipulation of the microbiota composition in order to improve the potentially beneficial aspects. The prebiotic approach dictates that non-viable food components are specifically fermented in the colon by indigenous bacteria thought to be of positive value, e.g. bifidobacteria, lactobacilli. Any food ingredient that enters the large intestine is a candidate prebiotic. However, to be effective, selectivity of the fermentation is essential. Most current attention and success has been derived using non-digestible oligosaccharides. Types primarily being looked at include those which contain fructose, xylose, soya, galactose, glucose and mannose. In particular, fructose-containing oligosaccharides, which occur naturally in a variety of plants such as onion, asparagus, chicory, banana and artichoke, fulfil the prebiotic criteria. Various data have shown that fructo-oligosaccharides (FOS) are specifically fermented by bifidobacteria. During controlled feeding studies, ingestion of these prebiotics causes bifidobacteria to become numerically dominant in faeces. Recent studies have indicated that a FOS dose of 4g/d is prebiotic. To exploit this concept more fully, there is a need for assessments of (a) improved determination of the gut microbiota composition and activity; (b) the use of molecular methodologies to assess accurately prebiotic identities and develop efficient bacterial probing strategies; (c) the prebiotic potential of raw and processed foods; and (d) the health consequences of dietary modulation.

Keywords

Gut floraPrebioticsFermentation
Type
Research Article
Information
British Journal of Nutrition , Volume 80 , supplement S2: Pre- and Probiotics: Where are We Today? , October 1998 , pp. S209 - S212
Copyright
Copyright © The Nutrition Society 1998

References

Buddington, RK, Williams, CH, Chen, SC & Witherly, SA (1996) Dietary supplementation of neosugar alters the fecal flora and decreases activities of some reductive enzymes in human subjects. American Journal of Clinical Nutrition 63, 709–716.Google Scholar
Cummings, JH & Macfarlane, GT (1991) A review: the control and consequences of bacterial fermentation in the human colon. Journal of Applied Bacteriology 70, 443–459.Google Scholar
Dixon, MF (1992) Helicobacter pylori and chronic gastritis. In Helicobacter pylori and Gastroduodenal Disease, 2nd edn, pp. 124–139 [Rathbone, BJ & Heatley, RV, editors]. Oxford: Blackwell Scientific Publications.Google Scholar
Finegold, SM, Sutter, VL & Mathisen, GE (1983) Normal indigenous intestinal flora. In Human Intestinal Microflora in Health and Disease, pp. 3–31 [Hentges, DJ, editor]. London: Academic Press.Google Scholar
Fuller, R [editor] (1992) Probiotics: The Scientific Basis. London: Chapman & Hall.Google Scholar
Fuller, R [editor] (1997) Probiotics 2: Applications and Practical Aspects. London: Chapman & Hall.Google Scholar
Gibson, GR, Beatty, EB, Wang, X & Cummings, JH (1995) Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology 108, 975–982.Google Scholar
Gibson, GR & Macfarlane, GT [editors] (1995) Human Colonic Bacteria. Role in Physiology, Pathology and Nutrition. CRC Press, Boca Raton.Google Scholar
Gibson, GR & Roberfroid, MB (1995) Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. Journal of Nutrition 125, 1401–1412.Google Scholar
Hidaka, H, Eida, T, Takiwaza, T, Tokunga, T & Tashiro, Y (1986) Effects of fructooligosaccharides on intestinal flora and human health. Bifidus Microflora 5, 37–50.Google Scholar
Holdeman, LV, Good, IJ & Moore, WEC (1976) Human fecal flora: variation in bacterial composition within individuals and a possible effect of emotional stress. Applied Environmental Microbiology 31, 359–375.Google Scholar
Kleessen, B, Sykura, B, Zunft, H-J & Blaut, M (1997) Effects of inulin and lactose on fecal microflora, microbial activity, and bowel habit in elderly constipated persons. American Journal of Clinical Nutrition 65, 1397–1402.Google Scholar
Macfarlane, GT & Gibson, GR (1994) Metabolic interactions between colonic bacteria and the host. In Human Health: the Contribution of Microorganisms, pp. 17–52 [Gibson, SAW, editor]. London: Springer-Verlag.Google Scholar
Moore, WEC & Holdeman, LV (1974) Human fecal flora: the normal flora of 20 Japanese-Hawaiians. Applied and Environmental Microbiology 27, 961–979.Google Scholar
Park, SF & Kroll, RG (1993) Expression of listeriolysin and phosphatidylinositol-specific phospholipase C is repressed by the plant-derived molecule cellobiose in Listeria monocytogenes . Molecular Microbiology 8, 653–661.Google Scholar
Parsonnet, J, Friedman, GD, Vandersteen, DP, Chang, Y, Vogelman, JH, Orentreich, N & Sibley, RK (1991) Helicobacter pylori and the risk of gastric carcinoma. New England Journal of Medicine 325, 1127–1131.Google Scholar
Simon, GL & Gorbach, SL (1982) Bacteriology of the colon. In The Colon: Structure and Function, pp. 103–114 (Bustos-Fernandez, L, editor]. London: Plenum Medical.Google Scholar
Wyatt, JI (1992) Helicobacter pylori, duodenitis and duodenal ulceration. In Helicobacter pylori and Gastroduodenal Disease, 2nd edn, pp. 140–149 [Rathbone, BJ & Heatley, RV, editors]. Oxford: Blackwell Scientific Publications.Google Scholar
Zopf, D & Roth, S (1996) Oligosaccharide anti-infective agents. Lancet 347, 1017–1021.Google Scholar