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Dietary magnesium intake can affect mechanical properties of rat carotid artery

Published online by Cambridge University Press:  09 March 2007

Pascal Laurant ,
Daniel Hayoz ,
Hans Brunner  and
Alain Berthelot
Pascal Laurant*
Affiliation:
Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
Daniel Hayoz
Affiliation:
Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
Hans Brunner
Affiliation:
Division of Hypertension, CHUV, 1011 Lausanne, Switzerland
Alain Berthelot
Affiliation:
Laboratoire Physiologie, Pharmacologie et Nutrition Préventive Expérimentale, UFR Médecine et Pharmacie, Place St-Jacques, 25030 Besançon Cedex, France
*
*Corresponding author: Pascal Laurant, fax +333 81 66 56 91, email [email protected]
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Abstract

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The purpose of the present study was to determine the effects of Mg deficiency and supplementation on the mechanical properties of the rat common carotid artery. The internal diameter and intra-arterial pressure of carotid artery were measured continuously using an echo-tracking device. Systolic, diastolic and mean intra-arterial pressures were not significantly different in Mg-deficient, -supplemented or control rats. Histological examination showed a larger cross-sectional area, increased intima-media thickness and a greater media:lumen value in carotid artery of Mg-deficient rats, indicating that Mg deficiency may directly stimulate growth and/or proliferation of arterial wall components. In addition, we observed a negative linear relationship between intima-media thickness and plasma Mg concentration, suggesting that increased Mg intake may counteract arterial wall hypertrophy. Neither Mg deficiency nor supplementation modified the arterial distensibility v. intra-arterial pressure curve or the Eincv. wall stress curve, indicating that dietary Mg intake did not modify wall stiffness in young rats. At mean intra-arterial pressure, the stress and Einc values were, however, significantly lower in Mg-deficient rats (P<0·05 in both cases); this finding could be related to the alteration in the geometry of the carotid artery. In conclusion, these findings suggest that Mg deficiency modifies the mechanical properties of the common carotid artery in young rats. Since Mg deficiency is considered a risk factor, these mechanical alterations could contribute to the development of atherosclerosis, hypertension and cardiovascular diseases.

Keywords

Magnesium intakeEcho trackingWall thicknessCalcium
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 5 , November 2000 , pp. 757 - 764
Copyright
Copyright © The Nutrition Society 2000

References

Altura, BM, Altura, BT, (1995) Role of magnesium in the pathogenesis of hypertension: relationship to its action on cardiac, vascular smooth muscle, and endothelial cells updated. [Laragh, JH and Brenner, BM]. In Hypertension: Pathophysiology, Diagnosis, and Management. 2nd ed. New York: Raven Press, pp. 1213–1242.Google Scholar
Altura, BM and Altura, BT (1995) Magnesium and cardiovascular biology: an important link between cardiovascular risk factors and atherogenesis. Cellular and Molecular Biology Research 4, pp. 347–359.Google Scholar
Altura, BM, Altura, BT, Carella, A, Gebrewold, A, Ising, H and Günther, T (1992) Noise-induced hypertension and magnesium in rats: relationship to microcirculation and calcium. Journal of Applied Physiology 72, pp. 194–202.CrossRefGoogle ScholarPubMed
Altura, BM, Altura, BT, Gebrewold, A, Ising, H and Günther, T (1984) Magnesium deficiency and hypertension: correlation between magnesium deficient diets and microcirculatory changes in situ. Science 223, pp. 1315–1317.Google Scholar
Altura, BT, Brust, M, Bloom, S, Barbour, RL, Stempak, JG and Altura, BM (1990) Magnesium dietary intake modulates blood lipid levels and atherogenesis. Proceedings of the National Academy of Sciences USA 87, pp. 1840–1844.CrossRefGoogle ScholarPubMed
Altura, BM, Zhang, A and Altura, BT (1993) Magnesium, hypertensive vascular diseases, atherogenesis, subcellular compartmentation of Ca2+ and Mg2+ and vascular contractility. Mineral and Electrolyte Metabolism 19, pp. 323–336.Google ScholarPubMed
Berthelot, A and Esposito, J (1983) Effects of dietary magnesium on the development of hypertension in the spontaneously hypertensive rat. Journal of the American College of Nutrition 4, pp. 343–353.Google Scholar
Bloom, S (1985) Coronary arterial lesions in Mg-deficient hamsters. Magnesium 4, pp. 82–95.Google Scholar
Bonithon-Kopp, C, Scarabin, PY, Taquet, A, Touboul, PJ, Malmejac, A and Guize, L (1991) Risk factors for early carotid atherosclerosis in middle-aged French women. Arteriosclerosis and Thrombosis 11, pp. 966–972.Google Scholar
Britton, WM and Stockstad, ELR (1970) Aorta and other soft tissue calcification in the magnesium-deficient rat. Journal of Nutrition 100, pp. 1501–1506.Google Scholar
Bussière, L, Mazur, A, Gueux, E, Nowacki, W and Rayssiguier, Y (1995) Triglyceride-rich lipoproteins from magnesium-deficient rats are more susceptible to oxidation by cells and promote proliferation of cultured vascular smooth muscle cells. Magnesium Research 8, pp. 151–158.Google ScholarPubMed
Caputo, L, Tedgui, A, Poitevin, P and Levy, BI (1992) In vitro assessment of diameter–pressure relationship in carotid arteries from normotensive and spontaneously hypertensive rats. Journal of Hypertension 10 (Suppl. 6), pp. 27–30.CrossRefGoogle ScholarPubMed
Cappuccio, FP, Markandu, ND, Beynon, GW, Shore, AC and Sampson, B (1985) Lack of effect of oral magnesium on high blood pressure: a double blind study. British Medical Journal 291, pp. 235–238.CrossRefGoogle ScholarPubMed
Cohen, L and Kitzes, R (1984) Magnesium sulfate in the treatment of variant angina. Magnesium 3, pp. 46–49.Google Scholar
Dobrin, PB (1983) Vascular mechanics. In Handbook of Physiology. vol. 3, sect. 2: The Cardiovascular System pp. 65–102. [Sheppard, JT and Abboud, FM]. Baltimore,MD: American Physiological Society.Google Scholar
Dyckner, T and Wester, PO (1983) Effect of magnesium on blood pressure. British Medical Journal 286, pp. 1847–1849.CrossRefGoogle ScholarPubMed
Eisenberg, MJ (1992) Mg deficiency and sudden death. American Heart Journal 124, pp. 544–549.Google Scholar
Fleckensteingrun, G (1996) Calcium antagonism in vascular smooth muscle cells. Pflügers Archiv 432, pp. R53–R60.Google Scholar
Folkow, B (1982) Physiological aspects of primary hypertension. Physiological Reviews 62, pp. 347–504.Google Scholar
(1995) ISIS-4: a randomized factorial trial assessing early oral captopril, oral mononitrate, and intravenous magnesium sulphate in 58 050 patients with suspected acute myocardial infarction. Lancet 345, pp. 669–685.Google Scholar
Galan, P, Preziosi, P, Durlach, V, Ribas, L, Bouzid, D, Fieux, B, Favier, A, Hercberg, S (1997) Dietary magnesium intake in French adult population. In Magnesium: Current Studies and New Developments. pp. 147–149. [Theophanides, T and Anastossopoulou, J]. Dordrecht, The Netherlands: Kluwer Academic Publishers.Google Scholar
Gueux, E, Azais-Braesco, V, Bussière, L, Grolier, P, Mazur, A and Rayssiguier, Y (1995) Effect of magnesium deficiency on triacylglycerol-rich lipoprotein and tissue susceptibility to peroxidation in relation to vitamin E content. British Journal of Nutrition 74, pp. 849–856.Google ScholarPubMed
Hayoz, D, Rutschmann, B, Perret, F, Niederberger, M, Tardy, Y, Mooser, V, Nussberger, J, Waeber, B and Brunner, HR (1992) Conduit artery compliance and distensibility are not necessarily reduced in hypertension. Hypertension 20, pp. 1–6.CrossRefGoogle Scholar
Heiss, G, Sharreu, AR, Barnes, R, Chambless, LE, Szklo, M, Alzola, C and (1991) Carotid atherosclerosis measured by B-mode ultrasound in populations: association with cardiovascular risk factors in the ARIC study. American Journal of Epidemiology 134, pp. 250–256.CrossRefGoogle ScholarPubMed
Itoh, K, Kawasaki, T and Nakamura, M (1997) The effect of high oral magnesium supplementation on blood pressure, serum lipids and related variables in apparently healthy Japanese subjects. British Journal of Nutrition 78, pp. 737–750.Google Scholar
Karppanen, H (1990) Epidemiologic evidence for considering magnesium deficiency as a risk factor for cardiovascular diseases. Magnesium Bulletin 12, pp. 80–86.Google Scholar
Kawano, Y, Matsuoka, H, Takishita, S and Omae, T (1998) Effects of magnesium supplementation in hypertensive patients. Assessment by office, home, and ambulatory blood pressures. Hypertension 32, pp. 260–265.CrossRefGoogle ScholarPubMed
Laurant, P, Kantelip, JP and Berthelot, A (1995) Dietary magnesium supplementation modifies blood pressure and cardiovascular function in mineralocorticoid-salt hypertensive rats but not in normotensive rats. Journal of Nutrition 125, pp. 830–841.Google ScholarPubMed
Laurant, P, Touyz, RM and Schiffrin, EL (1997) Effect of magnesium on vascular tone and reactivity in pressurized mesenteric resistance arteries from spontaneously hypertensive rats. Canadian Journal of Physiology and Pharmacology 75, pp. 293–300.Google Scholar
Laurant, P, Gueux, E, Dalle, M, Berthelot, A and Rayssiguier, Y (1999) Time-course change of the blood pressure level in magnesium-deficient Wistar rats. British Journal of Nutrition 82, pp. 243–251.CrossRefGoogle ScholarPubMed
Laurant, P, Hayoz, D, Brunner, HR and Berthelot, A (1999) Effect of dietary magnesium deficiency on blood pressure and mechanical properties of carotid artery in Wistar rats. Hypertension 33, pp. 1105–1110.CrossRefGoogle Scholar
Lerma, A, Planells, E, Aranda, P and Llopis, J (1995) Effect of magnesium deficiency on fatty acid composition of the erythrocyte membrane and plasma lipid concentration in rats. Journal of Nutritional Biochemistry 6, pp. 577–581.Google Scholar
Lichtman, AH, Segel, GB and Lichtman, MA (1983) The role of calcium in lymphocyte proliferation. Blood 61, pp. 413–422.CrossRefGoogle ScholarPubMed
Lucas, M, Leveno, K and Cunningham, F (1995) A comparison of magnesium sulfate with phenytoin for the prevention of eclampsia. New England Journal of Medicine 333, pp. 201–205.CrossRefGoogle ScholarPubMed
Luthringer, C, Rayssiguier, Y, Gueux, E and Berthelot, A (1988) Effect of moderate magnesium deficiency on serum lipids, blood pressure and cardiovascular reactivity in normotensive rats. British Journal of Nutrition 59, pp. 243–250.Google Scholar
Ma, J, Folsom, AR, Melnick, SL, Eckfeldt, JH, Sharrett, AR, Nabulsi, AA, Hutchinson, RG and Metcalf, PA (1995) Associations of serum and dietary magnesium with cardiovascular disease, hypertension, diabetes, insulin, and carotid arterial wall thickness: the ARIC study. Journal of Clinical Epidemiology 48, pp. 927–940.CrossRefGoogle ScholarPubMed
Marx, A and Neutra, RR (1997) Magnesium in drinking water and ischemic heart disease. Epidemiologic Reviews 19, pp. 258–272.Google Scholar
Muller, W, Iffland, R and Firsching, R (1993) Relationship between magnesium and elastic fibers. Magnesium Research 6, pp. 215–222.Google Scholar
Mulvany, MJ (1999) Vascular remodeling of resistance vessels: can we define this?. Cardiovascular Research 41, pp. 9–13.CrossRefGoogle Scholar
Nassir, F, Mazur, A, Giannoni, F, Gueux, E, Davidson, NO and Rayssiguier, Y (1995) Magnesium deficiency modulates hepatic lipogenesis and apolipoprotein gene expression in the rat. Biochemica et Biophysica Acta 1257, pp. 125–132.CrossRefGoogle ScholarPubMed
Niepper, HA (1974) Capillarographic criteria on the effect of magnesium orotate, EPL substances and clofibrate on the elasticity of blood vessels. Agressologie 15, pp. 73–78.Google Scholar
Orimo, H and Ouchi, Y (1990) The role of calcium and magnesium in the development of atherosclerosis. Experimental and clinical evidence. Annal of the New York Academy of Sciences 598, pp. 444–457.CrossRefGoogle ScholarPubMed
Rasmussen, HS, Aurup, P, Goldstein, K, McNair, P, Mortensen, PB, Larsen, OG and Lawaetz, H (1989) Influence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease. A double-blind, placebo controlled study. Archives of Internal Medicine 149, pp. 1050–1053.Google Scholar
Rayssiguier, Y and Gueux, E (1986) Magnesium and lipids in cardiovascular disease. Journal of the American College of Nutrition 5, pp. 507–519.Google Scholar
Rayssiguier, Y, Mazur, A, Gueux, E, Rock, E (1996) Magnesium deficiency affects lipid metabolism and atherosclerosis process by a mechanism involving inflammation and oxidative stress. In Current Research in Magnesium, pp. 251–255. [Halpern, MJ and Durlach, J, editors]. London: John Libbey & Co. Ltd.Google Scholar
Resnick, LM, Militianu, D, Cunnings, AJ, Pipe, JG, Evelhoch, JL and Soulen, RL (1997) Direct magnetic resonance determination of aortic distensibility in essential hypertension. Relation to age, abdominal visceral fat, and in situ intracellular free magnesium. Hypertension 30, pp. 654–659.CrossRefGoogle ScholarPubMed
Rock, E, Astier, C, Lab, C, Malpiech, C, Nowacki, W, Gueux, E, Mazur, A and Rayssiguier, Y (1995) Magnesium deficiency in rats induces a rise in plasma nitric oxide. Magnesium Research 8, pp. 237–242.Google ScholarPubMed
Saito, N, Okada, T, Moriki, T and Matsubayashi, K (1990) Long-term drinking of MgCl2 solution and arterial lesions in female SHRSP. Annals of the New York Academy of Sciences 598, pp. 527–529.Google Scholar
Seelig, MS (1964) The requirement of magnesium by the normal adult. American Journal of Clinical Nutrition 14, pp. 342–390.CrossRefGoogle ScholarPubMed
Seelig, MS (1989) Cardiovascular consequences of magnesium deficiency and loss; pathogenesis, prevalence and manifestations – magnesium and chloride loss in refractory potassium repletion. American Journal of Cardiology 63, pp. 4G–21G.Google Scholar
Shils, ES and Rude, RK (1996) Deliberations and evaluations of the approaches, endpoints and paradigms for magnesium deficiency recommendations. Journal of Nutrition 126, pp. 2398S–2403S.Google Scholar
Shivakumar, K and Prakash Kumar, B (1997) Magnesium deficiency enhances oxidative stress and collagen synthesis in vivo in the aorta of rats. International Journal of Biochemistry and Cell Biology 29, pp. 1273–1278.CrossRefGoogle ScholarPubMed
Weglicki, WB, Philips, TM, Freedman, AM, Cassidy, MM and Dickens, BF (1992) Magnesium deficiency elevates circulating levels of inflammatory cytokines and endothelin. Molecular Cell Biochemistry 110, pp. 169–173.Google Scholar
Woods, KL, Fletcher, S, Roffe, C and Haider, Y (1992) Intravenous magnesium sulphate in suspected acute myocardial infarction: results of the second Leicester Intravenous Magnesium Intervention Trial (LIMIT-2). Lancet 339, pp. 1553–1558.Google Scholar
Yokoyama, S, Smith, TL, Kawano, KKH and Kummerow, FA (1996) Effect of magnesium on secretion of platelet-derived growth factor by cultured human arterial smooth muscle cells. Magnesium Research 9, pp. 93–99.Google ScholarPubMed
Zanchi, A, Wiesel, P, Aubert, JP, Brunner, HR and Hayoz, D (1997) Time course changes of the mechanical properties of the carotid artery in renal hypertensive rats. Hypertension 29, pp. 1199–1203.Google Scholar
Zemel, PC, Zemel, MB, Urberg, M, Douglas, FL, Geiser, P and Sowers, JR (1990) Metabolic and hemodynamic effects of magnesium supplementation in patients with essential hypertension. American Journal of Clinical Nutrition 51, pp. 665–669.CrossRefGoogle ScholarPubMed
Zhang, A, Cheng, TPO and Altura, BM (1992) Magnesium regulates intracellular free ionized calcium concentration and cell geometry in vascular smooth muscle cells. Biochemica et Biophysica Acta 1134, pp. 25–29.CrossRefGoogle ScholarPubMed