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Dietary intake of folate by adolescents and the potential effect of flour fortification with folic acid

Published online by Cambridge University Press:  09 March 2007

P. J. Moynihan ,
A. J. Rugg-Gunn ,
T. J. Butler  and
A. J. Adamson
P. J. Moynihan*
Affiliation:
The Dental School, and the Human Nutrition Research Centre, University of Newcastle, Newcastel upon Tyne, UK
A. J. Rugg-Gunn
Affiliation:
The Dental School, and the Human Nutrition Research Centre, University of Newcastle, Newcastel upon Tyne, UK
T. J. Butler
Affiliation:
The Dental School, and the Human Nutrition Research Centre, University of Newcastle, Newcastel upon Tyne, UK
A. J. Adamson
Affiliation:
The Dental School, and the Human Nutrition Research Centre, University of Newcastle, Newcastel upon Tyne, UK
*
*Corresponding author: Dr. Paula J. Moynihan, fax +44 191 222 5928, email [email protected]
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Abstract

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The UK Department of Health recently recommended that flour be fortified with folic acid, at 2400 μg/kg. The objectives of the present paper were: to determine the consequence of this on folic acid intake of adolescents; to determine the level of fortification necessary to achieve an intake of 400 μg/d in adolescent girls (the amount recommended periconceptionally); to estimate the consequence of fortification on folic acid intake of high flour consumers; and to report on folate intake of adolescents. Dietary intake of folate and flour were determined by analysis of an existing database of the diets of 379 English adolescents. The folic acid intake that would result from white flour fortification with folic acid at 2400 μg/kg was determined and the level of folic acid fortification necessary to achieve an intake of 400 μg/d in girls from this source was also calculated. Without flour fortification, 6·9 % of girls failed to reach the UK lower reference nutrient intake for total folate. Fortification of white flour with folic acid at 2400 μg/kg would result in an additional folic acid intake of 191(SEM 6) μg/d in girls. To ensure 97 % of girls received 400 μg/d from white flour, white flour would need to be fortified at a level of 10 430 μg/kg, resulting in intakes of 1260 μg/d from flour in the highest (97·5 centile) female white flour consumers and 1422 μg/d from flour in the highest (97·5 centile) male white flour consumers.

Keywords

Folic acid fortification of flourDietary total folateDietary flour intakeAdolescents
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 4 , October 2001 , pp. 529 - 534
Copyright
Copyright © The Nutrition Society 2001

References

Adamson, AJ, Rugg-Gunn, AJ, Butler, TJ, Appleton, DR & Hackett, AF (1992) Nutritional intake height and weight of 11–12-year-old Northumbrian children in 1990 compared with information obtained in 1980. British Journal of Nutrition 68, 543–563.Google Scholar
Boushey, CJ, Beresford, SAA, Omenn, GS & Motulsky, AG (1995) A quantitative assessment of plasma homocysteine as a risk factor for vascular disease. Journal of the American Medical Association 274, 1049–1057.CrossRefGoogle ScholarPubMed
Clark, NAC & Fisk, NM (1994) Compliance with the Department of Health recommendations: routine folate prophylaxis to prevent fetal neural tube defects. British Journal of Obstetrics and Gynaecology 101, 709–710.Google Scholar
Crawley, HF (1993) The role of breakfast cereals in the diets of 16–17 year-old teenagers in Britain. Journal of Human Nutrition and Dietetics 6, 205–216.Google Scholar
Czeizel, AE & Dudas, I (1992) Prevention of first occurrence of neural tube defects by periconceptional vitamin supplementation. New England Journal of Medicine 327, 1832–1835.Google Scholar
Danesh, J & Lewington, S (1998) Plasma homocysteine and coronary heart disease: systematic review of published epidemiological studies. Journal of Cardiovascular Risk 5, 229–232.CrossRefGoogle ScholarPubMed
Department of Health (1991) Dietary Reference Values for Food Energy and Nutrients in the United Kingdom. Report on Health and Social Subjects no 41. London: H.M. Stationery Office.Google Scholar
Department of Health (1992) Folic Acid and the Prevention of Neural Tube Defect. London: H.M. Stationery Office.Google Scholar
Department of Health (2000) Folic Acid and the Prevention of Disease. Report on Health and Social Subjects no 50. London: H.M. Stationery Office.Google Scholar
Dunn, G (1989) Design and Analysis of Reliability Studies. London: Edward Arnold.Google Scholar
Garrow, JS (1974) Energy Balance and Obesity in Man, p. 47. London: North Holland Publishing Company Limited.Google Scholar
Giovanucci, E, Stampfer, MJ, Colditz, GA, Hunter, DJ, Fuchs, C, Rosner, BA, Speizer, FE & Willet, WC (1998) Multivitamin use folate and colon cancer in women in the nurses' health study. Annals of International Medicine 129, 517–524.Google Scholar
Hackett, AF, Rugg-Gunn, AJ & Appleton, DR (1983) Use of a dietary diary and interview to estimate the food intake of children. Human Nutrition: Applied Nutrition 37, 293–300.Google Scholar
Holland, B, Unwin, ID & Buss, DH (1988) Cereals and Cereal Products. The Third Supplement to McCance and Widdowson's 'The Composition of Foods'. London: H.M. Stationery Office.Google Scholar
Holland, B, Unwin, ID & Buss, DH (1989) Milk and Milk Products. The Fourth Supplement to McCance and Widdowson's 'The Composition of Foods'. London: H.M. Stationery Office.Google Scholar
Hunter, R, Barnes, J, Oakeley, HF & Matthews, DM (1970) Toxicity of folic acid given in pharmacological doses to healthy volunteers. Lancet 1, 61–62.Google Scholar
Institute of Medicine (1998) Dietary Reference Intakes: Folate, other B Vitamins and Choline. Washington, DC: National Academy Press.Google Scholar
Jacques, PF, Selhub, J, Bostom, AG, Wilson, PWF & Rosenberg, IH (1999) The effect of folic acid fortification on plasma folate and total homocysteine concentrations. New England Journal of Medicine 340, 1449–1454.CrossRefGoogle ScholarPubMed
Kelly, P, McPartlin, J, Goggins, M, Weir, DG & Scott, JM (1997) Unmetabolised folic acid in serum: acute studies in subjects consuming fortified food and supplements. American Journal of Clinical Nutrition 65, 1790–1795.CrossRefGoogle Scholar
Kirke, PN, Daly, LE & Elwood, JH (1992) A randomised trial of low dose folic acid to prevent neural tube defects. Archives of Diseases of Childhood 67, 1442–1446.CrossRefGoogle ScholarPubMed
Laurence, KM, James, N, Miller, MH, Tennent, GB & Campbell, H (1981) Double-blinded randomised controlled trial of folate treatment before conception to prevent recurrence of neural tube defects. British Medical Journal 282, 1509–1511.CrossRefGoogle ScholarPubMed
Lawrence, JM, Petitti, DB, Watkins, M & Umekubo, MA (1999) Trends in serum folate after food fortification. Lancet 354, 915–916.CrossRefGoogle ScholarPubMed
Lucock, MD, Wild, J, Smithells, R & Hartley, R (1989) In vivo characterisation of the absorption and biotransformation of pteroylglutamin acid in man: A model for future studies. Biochemical Medicine and Metabolic Biology 42, 30–42.CrossRefGoogle Scholar
Malinow, MR, Duell, PB, Hess, DL, Anderson, PH, Kruger, WD, Phillipson, BE, Glkuckman, RA, Block, PC & Upson, BM (1998) Reduction of plasma homocysteine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease. New England Journal of Medicine 338, 1009–1015.CrossRefGoogle ScholarPubMed
Medical Research Council Vitamin Study Research Group (1991) Prevention of neural tube defects: results of the MRC Vitamin Study. Lancet 338, 132–137.Google Scholar
Moynihan, PJ, Adamson, AJ, Rugg-Gunn, AJ, Appleton, DR & Butler, TJ (1996) Dietary sources of calcium and the contribution of flour fortification to total calcium intake in the diets of Northumbrian adolescents. British Journal of Nutrition 75, 495–505.CrossRefGoogle ScholarPubMed
Paul, AA & Southgate, DAT (1978) McCance and Widdowson's 'The Composition of Foods', 4th ed. London: H.M. Stationery Office.Google Scholar
Register General (1980) Classification of Occupations 1980. Office of Populations Censuses and Surveys. London: H.M. Stationery Office.Google Scholar
Rugg-Gunn, AJ, Hackett, AF, Appleton, DR, Eastoe, JE, Dowthwaite, L & Wright, WG (1987) The water intake of 405 Northumbrian adolescents aged 12–14 years. British Dental Journal 162, 335–340.CrossRefGoogle ScholarPubMed
Ruxton, CHS, O'Sullivan, KR, Kirk, TR & Belton, NR (1996) The contribution of breakfast to the diets of a sample of 136 primary-schoolchildren in Edinburgh. British Journal of Nutrition 75, 419–431.Google Scholar
Simmer, K, Iles, CA, James, C & Thompson, RPH (1987) Are iron-folate supplements harmful? American Journal of Clinical Nutrition 45, 122–125.CrossRefGoogle ScholarPubMed
Tan, SP, Wenlock, RW & Buss, DH (1985) Immigrant Foods. Second supplement to McCance and Widdowson's 'The Composition of Foods'. London: H.M. Stationery Office.Google Scholar
Wild, J, Schorah, CJ, Maude, K & Levene, MI (1996) Folate intake in young women and their knowledge of pre-conceptional folate supplementation to prevent neural tube defects. European Journal of Obstetritics, Gynecology and Reproductive Biology 70, 185–189.CrossRefGoogle Scholar
Young, CM & Trulson, MF (1960) Methodology for dietary studies in epidemiological surveys II. Strengths and weaknesses of existing methods. American Journal of Public Health 50, 803.CrossRefGoogle ScholarPubMed