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Dietary indices of atherogenicity and thrombogenicity and ischaemic heart disease risk: the Caerphilly Prospective Study

Published online by Cambridge University Press:  09 March 2007

A. M. Fehily ,
J. E. Pickering ,
J. W. G. Yarnell  and
P. C. elwood
A. M. Fehily
Affiliation:
Medical Research Council Epidemiology Unit, Llundough Hospital, Penarth, South Glmzorgan CF6 IXX
J. E. Pickering
Affiliation:
Medical Research Council Epidemiology Unit, Llundough Hospital, Penarth, South Glmzorgan CF6 IXX
J. W. G. Yarnell
Affiliation:
Medical Research Council Epidemiology Unit, Llundough Hospital, Penarth, South Glmzorgan CF6 IXX
P. C. elwood
Affiliation:
Medical Research Council Epidemiology Unit, Llundough Hospital, Penarth, South Glmzorgan CF6 IXX
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Abstract

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The aim of the study was to investigate whether proposed dietary scores of atherogenicity and thrombogenicity predict ischaemic heart disease (IHD) risk in a community sample of men aged 45–59 years. Dietary scores were calculated from consumption of various fatty acids, estimated from 7 d weighed intake data obtained from 665 men. Investigation of associations with blood lipids, lipoproteins and haemostatic factors revealed positive associations with low-density-lipoprotein cholesterol (P < 0·05) and white cell count (P < 0·05), and a negative association with antithrombin III (P = 0·05), after taking into account the effects of age, body mass index and smoking. During a 5-year follow-up period, there were twenty-one new IHD events among the 512 men in whom there was no evidence of IHD at baseline. Men with higher atherogenicity or thrombogenicity scores at baseline tended to have a higher risk of subsequent IHD. The trend was consistent but not statistically significant. A similar trend was observed for total saturates, and an inverse trend for total polyunsaturates, expressed as a percentage of total fatty acids. It is, therefore, concluded that proposed dietary indices of atherogenicity and thrombogenicity may be weak predictors of IHD risk, but that these scores are unlikely to be substantially better predictors than more simple approaches such as intakes of total saturates. To enhance the predictive ability, more complex formulas which take into account other dietary factors as well as fatty acid intakes would probably be required.

Keywords

Fatty acidsDietIschaemic heart disease
Type
Diet and Coronary Heart Disease
Information
British Journal of Nutrition , Volume 71 , Issue 2 , February 1994 , pp. 249 - 257
Copyright
Copyright © The Nutrition Society 1994

References

REFERENCES

Armitage, P. (1977). Statistica1 Methods in Medical Research, pp. 427–433. Oxford: Blackwell Scientific Publications.Google Scholar
Bonanome, A. & Grundy, S. M. (1988). Effect of dietary stearic acid on plasma cholesterol level and lipoprotein levels. New England Journal of Medicine 318, 1244–1248.CrossRefGoogle ScholarPubMed
Burr, M. L. (1989). Fish and the cardiovdscukir system. Progress in Food and Nutrition Science 13, 291–316.Google ScholarPubMed
Burr, M. L., Fehily, A. M., Gilbert, J. F., Rogers, S., Holliday, R. M., Sweetnam, P. M., Elwood, P. C. & Deadman, N. M. (1989). Effects of changes in fat, fish and fibre intakes on death and myocardial reinfarction: Diet and Reinfarction Trial (DART). Lancet 2, 757–761.CrossRefGoogle ScholarPubMed
Caerphilly and Speedwell Collaborative Group (1984). Caerphilly and Speedwell collaborative heart disease studies. Journal of Epidetniology and Community Health 38, 259–262.CrossRefGoogle Scholar
Fehily, A. M., Phillips, K. M. & Sweetnam, P. M. (1984). A weighed dietary survey of men in Caerphilly, South Wales. Human Nutrition Applied Nutrition 38A, 270–276.Google Scholar
Fehily, A. M., Yarnell, J. W. G., Bolton, C. H. & Butland, B. K. (1988). Dietary determinants of blood lipids and lipoproteins: the Caerphilly study. European Journal of Clinical Nutrition 42, 405–413.Google ScholarPubMed
Fehily, A. M., Yarnell, J. W. G., Pickering, J. & Elwood, P. C. (1992 a). Coronary heart disease and dietary factors. Lancet 339, 987–988.CrossRefGoogle ScholarPubMed
Fehily, A. M., Yarnell, J. W. G., Sweetnam, P. M. & Elwood, P. C. (1992 b). Diet and incident ischaemic heart disease: the Caerphilly study. British Journal of Nutrition 69, 303–314.CrossRefGoogle Scholar
Friedman, G. D., Klatsky, A. L. & Siegelaub, A. B. (1974). The leucocyte count as a predictor of myocardial infarction. New England Journal of Medicine 290, 1275–1278.CrossRefGoogle ScholarPubMed
Friedman, G. D., Tekawa, I., Grimm, R. H., Manolio, T., Shaman, S. G. & Sidney, S. (1990). The leucocyte count: correlates and relationship to coronary risk factors. The CARDIA study. International Journal of Epidemiology 19, 889–893.CrossRefGoogle ScholarPubMed
Garcia-Palmieri, M. R.Sorlie, P.Tillotson, J.Costas, R., Cordero, E. & Rodriguez, M. (1980). Relationship of dietary intake to subsequent coronary heart disease incidence: the Puerto Rico Heart Health Programme. American Journal of Clinical Nutrition 33, 1818–1827.CrossRefGoogle Scholar
Gordon, T., Kagan, A., Garcia-Palmieri, M., Kannel, W. B., Zukel, W. J., Tillotson, J., Sorlie, P. & Hjortland, M. (1981). Diet and its relation to coronary heart disease and death in three populations. Circulation 63, 500–515.CrossRefGoogle ScholarPubMed
Grimm, R. H., Neaton, J. D. & Ludwig, W. (1985). Prognostic importance of the white cell count for coronary. cancer and all cause mortality. Journal of American Medical Association 254, 1932–1937.CrossRefGoogle ScholarPubMed
Gurr, M. I., Borlak, N. & Ganatra, S. (1989). Dietary fat and plasma lipids. Nutrition Research Reviews 2, 63–86.CrossRefGoogle ScholarPubMed
Hansen, L. K., Grimm, R. H. & Neaton, J. D. (1990). The relationship of white blood cell count to other cardiovscular risk factors. International Journal of Epidemiology 19, 881–888.CrossRefGoogle Scholar
Hedner, U. & Nilsson, I. M. (1973). Antithrombin III in a clinical material. Thrombosis Research 3, 631–641.CrossRefGoogle Scholar
Hornstra, G. & Lussenberg, R. N. (1975). Relationship between the type of dietary fatty acid and the arterial thrombus tendency in rats. Atherosclerosis. 22, 499–516.CrossRefGoogle ScholarPubMed
Keys, A., Anderson, J. T. & Grande, F. (1965). Serum cholesterol response to changes in the diet. IV. Particular saturated fatty acids in the diet. Metabolism 14, 776–787.CrossRefGoogle ScholarPubMed
Kromhout, D. & Coulander, C. L. (1984). Diet. prevalence and 10-year mortality from coronary heart disease in 871 middle-aged men. The Zutphen study. American journal of Epidemology 119, 733–741.CrossRefGoogle ScholarPubMed
Kushi, L. H., Lew, R. A., Stare, F. J., Ellison, C. R., El Lozy, M., Bourke, G., Daly, L., Graham, I., Hickey, N., Mulcahy, R. & Kevaney, J. (1985). Diet and 20-year mortality from coronary heart disease: the Ireland-Boston diet-heart study. New England Journal of Medicine 312, 811–818.CrossRefGoogle ScholarPubMed
Lopez-Virella, M. F.. Stone, P.. Ellis, S. & Colwell, J. A. (1977). Cholesterol determination by three different methods. Clinical Chemistry, 23, 882–884.CrossRefGoogle Scholar
McGee, D. L., Reed, D. M.. Yam, K.. Kagan, A. & Tillotsoii, J. (1984). Ten-year incidence of coronary heart disease in the Honolulu heart programme: relationship to nutrient intake. American Journal of Epidemiology, 119, 667–676.CrossRefGoogle ScholarPubMed
Meade, I. W.Cooper, J., Miller, G. J., Howarth, D. J. & Stirling, Y. (1991). Antithrombin 111 and arterial disease. Lancet, 338, 850–851.CrossRefGoogle Scholar
Miettinen, T. A.Naukkarinen, V., Huttunen, J. K., Mattiln, S. & Kumlin, T. (1982). Fatty acid composition of serum lipids predicts myocardial infarction. British Medical Journal 285, 993–995.CrossRefGoogle ScholarPubMed
Morris, J. N., Marr, J. W. & Clayton, D. G. (1977). Diet and heart: a postscript. British Medical Journal, 2, 1307–1312.CrossRefGoogle Scholar
O'Brien, J. R., Etherington, M. D. & Jamieson, S. (1976 a). Acute platelet changes after large meals of saturated and unsaturated fats. Lancet, 1, 878–880.CrossRefGoogle ScholarPubMed
O'Bricn, J. R.Etherington, M. D., Jamieson, S.Lawford, P.Susaex, J. & Lincoln, S. V. (1975). Heparin neutralising activity test in the diagnosis of acute myocardial infarction. Journal of Clinical Pathology, 28, 975–979.CrossRefGoogle Scholar
O'Brien, J. R., Etherington, M. D., Jamieson, S., Vergroeson, A. J. & Ten Haar, F. T. (1976 b). Effect of a diet of polyunsaturated fats on some platelet function tests. Lancet 2, 995–997.CrossRefGoogle ScholarPubMed
Paul, A. A., Southgate, D. A. T. & Russell, J. (1980). First Suppliment to McCance and Widdowson's the Composition of Foods. London: HM Stationery Office.Google Scholar
Posner, B. M., Cobb, J. L., Bellanger, A. J., Cupples, L. A., D'Agostino, R. B. & Stokes, J. (1991). Dietary lipid predictors of coronary heart diseasc in men: the Framingham study. Archives of Internal Medicine, 151, 1181–1187.CrossRefGoogle Scholar
Rogers, S., Yarnell, J. W. G. & Fehily, A. M. (1988). Nutritional determinants of haemostatic factors in the Caerphilly study. European Journal of Clinical Nutrition, 42, 197–205.Google ScholarPubMed
Rose, G. & Blackburn, H. (1968). Cardiovascular Survey Methods. WHO Monograph Series, no. 56. Geneva: WHO.Google ScholarPubMed
Schwartz, J. & Wciss, S. T. (1991). Host and environmental factors influencing the peripheral blood leucocyte count. American Journal of Epidemiology, 134, 1402–1409.CrossRefGoogle Scholar
Shekelle, R. B., MacMillan Shryock, A., Paul, O., Lepper, M., Stainler, J., Liu, S. & Raynor, W. J. (1981). Diet, serum cholesterol and death from coronary heart disease. New England Journal of Medicine 304, 65–70.CrossRefGoogle ScholarPubMed
Thorp, J. M., Horsfall, G. B. & Stone, M. C. (1967). A new red-sensitive micro-nephelometer. Medical and Biological Engineering, 5, 51–56.CrossRefGoogle Scholar
Ulbricht, T. L. V. & Southgate, D. A. T. (1991). Coronary heart disease: seven dietary factors. Lancet 338, 985–992.CrossRefGoogle ScholarPubMed
Verstraete, M. & Vermylen, J. (1984). Thrombosis. Oxford: Pergamon Press.Google Scholar
Weiss, S. J. (1989). Tissue destruction by neutrophils. New Englmd Journal of Medicine 320, 365–375.Google ScholarPubMed
Yarnell, J. W. G., Baker, I. A., Sweetnam, P. M., Bainton, D., O'Brien, J. R., Whitehead, P. J. & Elwood, P. C. (1991). Fibrinogen, viscosity and white cell count are major risk factors for ischaemic heart disease. The Caerphilly and Speedwell Collaborative Heart Disease Studies. Circulation 83, 836–844.CrossRefGoogle ScholarPubMed
Yarnell, J. W. G., Sweetnam, P. M., Elwood, P. C., Eastham, R., Gilmour, R. A., O'Brien, J. R. & Etherington, M. D. (1985). Haemostatic factors and ischaemic heart disease. The Caerphilly study. British Heart Journal 53, 483–487.CrossRefGoogle ScholarPubMed
Zalokar, J. D., Richard, J. L. & Clande, J. R. (1981). Leucocyte count, smoking and myocardial infarction. New England Journal of Medicine 304, 465–468.CrossRefGoogle ScholarPubMed