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Dietary fibre and sterol metabolism in the rat

Published online by Cambridge University Press:  24 July 2007

B. Morgan ,
Monique Heald ,
Sandra D. Atkin ,
J. Green  and
E. B. Chain
B. Morgan
Affiliation:
Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey
Monique Heald
Affiliation:
Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey
Sandra D. Atkin
Affiliation:
Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey
J. Green
Affiliation:
Beecham Research Laboratories, Nutritional Research Centre, Walton Oaks, Tadworth, Surrey
E. B. Chain
Affiliation:
Department of Biochemistry, Imperial College of Science and Technology, London
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Abstract

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1. Sterol metabolism was studied in rats fed on a semi-synthetic fibre-free diet and in rats fed on diets containing cellulose (200 or 100 g/kg) or sugar-cane fibre (bagasse) at the same levels.

2. Rats fed on the diets containing cellulose or bagasse produced significantly greater quantities of faeces than did rats fed on the fibre-free diet.

3. Rats given bagasse excreted more bile acid and more neutral sterol in their faeces than did rats fed on cellulose or on the fibre-free diet.

4. After 28 d, hepatic synthesis of cholesterol (from acetate) and cholesterol 7α-hydroxylase activity were significantly higher in animals fed on bagasse than in animals fed on the other two diets.

5. No significant differences in serum cholesterol levels were seen in rats fed on any of the three diets.

6. Food consumption was not substantially altered by the inclusion of bagasse or cellulose in the diets, although the efficiency of foodstuff utilization was generally lower.

7. Bagasse adsorbed substantial quantities of cholic acid in vitro, whereas cellulose did not. The lignin fraction prepared from bagasse contributed only slightly to the total bile acid-binding capacity of bagasse.

8. The results are discussed in the light of possible effects of dietary fibre on sterol metabolism in man.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 32 , Issue 2 , September 1974 , pp. 447 - 455
Copyright
Copyright © The Nutrition Society 1974

References

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