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Dietary ascorbic acid and muscle carnitine (β-OH-γ-(trimethylamino) butyric acid) in guinea-pigs

Published online by Cambridge University Press:  25 February 2008

R. E. Hughes
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
R. J. Hurley
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
Eleri Jones
Affiliation:
University of Wales Institute of Science and Technology, Cardiff, Wales
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Abstract

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Tissue ascorbic acid (AA) contents of approximately 12 and 100% saturation respectively were produced in two groups of guinea-pigs. The ‘low-AA’ group had significantly lower muscle carnitine concentrations than the ‘high-AA’group. There was no concomitant emergence of the symptoms customarily regarded as characteristic of hypovitaminosis C. It is concluded that muscle carnitine (β-OH-γ-(trimethylamino) butyric acid) is a highly-sensitive indicator of tissue AA contents; this could account for the lassitude and fatigue reported to precede the emergence of frank scurvy in man.

Type
Short Papers
Copyright
Copyright © The Nutrition Society 1980

References

Barnes, M. J. (1975). Ann. N.Y. Acad. Sci. 258, 264.CrossRefGoogle Scholar
Bremer, J. (1977). Trends in Biochem. Sci. 2, 207.Google Scholar
Crandon, J. H., Lund, C. G. & Dill, D. B. (1940). New Engl. J. Med. 223, 353.CrossRefGoogle Scholar
Engel, A. G., Banker, B. Q. & Eiben, R. M. (1977). J. Neurol. Neurosurg. Psychiat. 40, 313.CrossRefGoogle Scholar
Hughes, R. E. (1965). Br. J. Nutr. 19, 307.CrossRefGoogle Scholar
Hulse, J. D., Ellis, S. R. & Henderson, L. M. (1978). J. biol. Chem. 263, 1654.CrossRefGoogle Scholar
Khan, L. & Bamji, M. S. (1979). J. Nutr. 109, 24.CrossRefGoogle Scholar
Lind, J. (1753). A Treatise of the Scurvy, p. 148. Edinburgh, London: A. Millar.Google Scholar
Marquis, N. R. & Fritz, I. B. (1964). J. Lipid Res. 5, 184.CrossRefGoogle Scholar
Wahlefeld, A. W. (1974). In Methods of Enzymatic Analysis, 2nd Engl. ed., p. 1831, [Bergmeyer, H. V. editor]. New York and London: Verlag Chemie Weinheim and Academic Press.CrossRefGoogle Scholar
Williams, Rh. S. & Hughes, R. E. (1972). Br. J. Nutr. 28, 167.CrossRefGoogle Scholar
Woodall, J. (1639). The Surgeons Mate or Military and Domestique Surgery, p. 162. London: Nicholas Bourne.Google Scholar