Hostname: page-component-586b7cd67f-2plfb Total loading time: 0 Render date: 2024-11-23T21:29:23.787Z Has data issue: false hasContentIssue false
  • English
  • Français

Diet composition and lipoprotein lipase (EC 3.1.1.34) activity in human obesity

Published online by Cambridge University Press:  09 March 2007

Lori A. Smolin ,
Mary B. Grosvenor ,
David J. Handelsman  and
Jo Anne Brasel
Lori A. Smolin
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
Mary B. Grosvenor
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
David J. Handelsman
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
Jo Anne Brasel
Affiliation:
Division of Endocrinology, Metabolism and Nutrition, Departments of Pediatrics and Medicine, UCLA School of Medicine and Harbor- UCLA Medical Center, Torrance, California 90509, USA
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Adipose tissue lipoprotein lipase (EC 3.1.1.34; AT-LPL), a rate-limiting enzyme in triglyceride storage in adipose tissue, is hormonally regulated and may be important in the maintenance of obesity.

2. In twelve obese women, AT-LPL activity was measured before weight loss, during weight loss and after 1 and 2 weeks of weight maintenance on either a high-carbohydrate or a high-protein diet.

3. When related to tissue weight, AT-LPL activity during the 2 weeks of weight maintenance was higher than the initial AT-LPL activity; there was no difference when activity was expressed per cell.

4. Changes in AT-LPL activity were not affected by diet composition. AT-LPL activity correlated with insulin levels and a change in the insulin sensitivity of AT-LPL was observed after weight loss.

Type
Clinical and Human Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 13 - 21
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Bosello, O., Cigolini, M., Battaggia, A., Ferrari, F., Micciolo, R., Olivetti, R. & Corsato, M. (1984). International Journal of Obesity 8, 213–220.Google Scholar
Bray, G. A. & Campfield, A. (1975). Metabolism: Clinical & Experimental 24, 99–117.CrossRefGoogle Scholar
Brunzell, J. D. & Greenwood, M. R. C. (1983). In Biochemical Pharmacology of Metabolic Disease States, pp. 175–189 [Curtis-Prior, T. B., editor]. Amsterdam: Elsevier, North Holland.Google Scholar
Dahms, W. T., Nilsson-Ehle, P., Garfinkel, A. S., Atkinson, R. L., Bray, G. A. & Schotz, M. C. (1981). International Journal of Obesity 5, 81–84.Google Scholar
Dixon, W. J. [editor] (1983). BMDP Statistical Software. Berkeley, CA: University of California Press.Google Scholar
Folch, J., Lees, M. & Sloane-Stanley, G. H. (1957). Journal of Biological Chemistry 226, 497–509.CrossRefGoogle Scholar
Guy-Grand, B. & Bigorie, B. (1975). Hormonal and Metabolic Research 7, 471–475.Google Scholar
Heitanen, E. & Greenwood, M. R. C. (1977). Journal of Lipid Research 18, 480–490.Google Scholar
Hirsch, J. & Gallian, E. (1968). Journal of Lipid Research 9, 110–119.CrossRefGoogle Scholar
Hollenberg, C. H. (1966). Journal of Clinical Investigation 45, 205–216.CrossRefGoogle Scholar
Kissebah, A. H., Vydelingum, N., Murray, R., Evans, D. J., Hartz, A. J., Kalkhoff, R. K. & Adams, P. W. (1982). Journal of Clinical Endocrinology and Metabolism 54, 254–260.CrossRefGoogle Scholar
Kolterman, O.G., Insel, J., Saekow, M. & Olefsky, J. M. (1980). Journal of Clinical Investigation 65, 1272–1284.Google Scholar
Lascuncion, M. A. & Herrera, E. (1983). Biochemical Journal 210, 639–643.Google Scholar
Lithell, H. & Boberg, J. (1978). International Journal of Obesity 2, 47–54.Google Scholar
Metropolitan Life Insurance Height & Weight Tables (1983). Statistics Bulletin 64, 9.Google Scholar
Nilsson-Ehle, P. & Schotz, M. C. (1976). Journal of Lipid Research 17, 536–541.Google Scholar
Olefsky, J. M. (1976). Journal of Clinical Investigation 57, 1165–1172.Google Scholar
Pykälistö, O.J., Smith, P. H. & Brunzell, J. D. (1975). Journal of Clinical Investigation 56, 1108–1117.CrossRefGoogle Scholar
Rebuffe-Serive, M., Basdevant, A. & Guy-Grand, B. (1983). American Journal of Clinical Nutrition 37, 974–980.CrossRefGoogle Scholar
Reitman, J. S., Kosmakos, F. C. & Howard, B. V. (1982). Journal of Clinical Investigation 70, 791–797.Google Scholar
Sadur, C. N., Yost, T. J. & Eckel, R. H. (1984). Journal of Clinical Endocrinology and Metabolism 59, 1176–1182.CrossRefGoogle Scholar
Schwartz, R. S. & Brunzell, J. D. (1978). Lancet i, 1230–1231.Google Scholar
Schwartz, R. S. & Brunzell, J. D. (1981). Journal of Clinical Investigation 67, 1425–1430.Google Scholar
Sims, E. A. H., Danforth, E., Horton, E. S., Bray, G. A., Glennon, J. A. & Salans, L. (1973). Recent Progress in Hormonal and Metabolic Research 29, 457–487.Google Scholar
Sörbris, R., Peterson, B. G. & Nilsson-Ehle, P. (1981). European Journal of Clinical Investigation 11, 491–498.Google Scholar
Taskinen, M. -R. & Nikkilä, E. A. (1977). Acta Medica Scandinavia 202, 399–408.Google Scholar
Taskinen, M. -R. & Nikkilä, E. A. (1979). Diabetologia 17, 351–356.Google Scholar
Taskinen, M. -R. & Nikkilä, E. A. (1981). Metabolism 30, 810–817.CrossRefGoogle Scholar
Taylor, K. G., Golton, D. J. & Holdsworth, G. (1979). Diabetologia 16, 313–322.Google Scholar