Hostname: page-component-cd9895bd7-q99xh Total loading time: 0 Render date: 2024-12-23T15:44:24.135Z Has data issue: false hasContentIssue false
  • English
  • Français

Determinants of plasma dihydrophylloquinone in men and women

Published online by Cambridge University Press:  08 March 2007

Arja T. Erkkilä ,
Alice H. Lichtenstein ,
Paul F. Jacques ,
Frank B. Hu ,
Peter W. F. Wilson  and
Sarah L. Booth
Arja T. Erkkilä
Affiliation:
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA Department of Clinical Nutrition, University of Kuopio, Kuopio, Finland
Alice H. Lichtenstein
Affiliation:
Cardiovascular Nutrition Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Paul F. Jacques
Affiliation:
Epidemiology Program, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
Frank B. Hu
Affiliation:
Department of Nutrition, Harvard School of Public Health, Boston, MA 02115 and Channing Laboratory, Boston, MA 02115, USA
Peter W. F. Wilson
Affiliation:
Medical University of South Carolina, Charleston, SC 29425 and the National Heart, Lung and Blood Institute's Framingham Heart Study, Framingham, MA 01701, USA
Sarah L. Booth*
Affiliation:
Vitamin K Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, 711 Washington Street, Boston, MA 02111, USA
*
*Corresponding author: Dr Sarah L. Booth, fax +1 617 556 3149, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Commercial hydrogenation results in the formation of trans fatty acids. An unintended consequence of the hydrogenation process is conversion of phylloquinone (vitamin K1) to dihydrophylloquinone. Plasma dihydrophylloquinone concentrations have yet to be characterized in population-based studies. Dietary determinants of plasma dihydrophylloquinone were estimated using a semi-quantitative food frequency questionnaire in 803 men and 913 women in the Framingham Offspring Study. Geometric mean dihydrophylloquinone intake was 21·3 (95 % CI 20·4, 22·3) μg/d in men and 19·4 (95 % CI 18·5, 20·2) μg/d in women. Detectable (>0·05 nmol/l) plasma dihydrophylloquinone concentrations were measured in 41 % and 30 % of men and women, respectively. The multivariate odds ratio (OR) of detectable plasma dihydrophylloquinone from the lowest to the highest quartile category of dihydrophylloquinone intake were 1 (referent), 1·13 (95 % CI 0·83, 1·53), 1·66 (95 % CI 1·21, 2·26) and 1·84 (95 % CI 1·31, 2·58), P for trend <0·001, adjusted for sex, age, body mass index, triacylglycerols, season and energy intake. Higher trans fatty acid intake was associated with higher multivariate OR for detectable plasma dihydrophylloquinone (OR comparing extreme quartiles 2·41 (95 % CI 1·59, 3·64), P for trend <0·001). There were limitations in the use of plasma dihydrophylloquinone, evident in the high proportion of the population that had non-detectable dihydrophylloquinone concentrations. Despite this caveat, higher plasma dihydrophylloquinone was associated with higher dihydrophylloquinone intake and higher trans fatty acid intake.

Keywords

DihydrophylloquinoneVitamin KTrans fatty acidsBiomarker
Type
Research Article
Information
British Journal of Nutrition , Volume 93 , Issue 5 , May 2005 , pp. 701 - 708
Copyright
Copyright © The Nutrition Society 2005

References

Booth, SL, Davidson, KW, Lichtenstein, AH & Sadowski, JA (1996a) Plasma concentrations of dihydro-vitamin K1 following dietary intake of a hydrogenated vitamin K1-rich vegetable oil. Lipids 31, 709–713.CrossRefGoogle ScholarPubMed
Booth, SL, Lichtenstein, AH, O'Brien-Morse, M, McKeoun, NM, Wood, RJ, Saltzman, E & Gundberg, CM (2001) Effects of a hydrogenated form of vitamin K on bone formation and resorption. Am J Clin Nutr 74, 783–790.CrossRefGoogle ScholarPubMed
Booth, SL, O'Brien-Morse, ME, Dallal, GE, Davidson, KW & Gundberg, CM (1999a) Response of vitamin K status to different intakes and sources of phylloquinone-rich foods: comparison of younger and older adults. Am J Clin Nutr 70, 368–377.CrossRefGoogle ScholarPubMed
Booth, SL, Pennington, JA & Sadowski, JA (1996b) Dihydro-vitamin K1: primary food sources and estimated dietary intakes in the American diet. Lipids 31, 715–720.CrossRefGoogle ScholarPubMed
Booth, SL & Suttie, JW (1998) Dietary intake and adequacy of vitamin K. J Nutr 128, 785–788.CrossRefGoogle ScholarPubMed
Booth, SL, Webb, DR & Peters, JC (1999b) Assessment of phylloquinone and dihydrophylloquinone dietary intakes among a nationally representative sample of US consumers using 14-day food diaries. J Am Diet Assoc 99, 1072–1076.CrossRefGoogle ScholarPubMed
Davidson, KW, Booth, SL, Dolnikowski, GG & Sadowski, JA (1996) The conversion of phylloquinone to 2',3'-dihydrophylloquinone during hydrogenation of vegetable oils. J Agric Food Chem 44, 980–983.CrossRefGoogle Scholar
Davidson, KW & Sadowski, JA (1997) Determination of vitamin K compounds in plasma or serum by high-performance liquid chromatography using postcolumn chemical reduction and fluorimetric detection. Methods Enzymol 282, 408–421.CrossRefGoogle ScholarPubMed
Dumont, JF, Peterson, J, Haytowitz, D & Booth, SL (2003) Phylloquinone and dihydrophylloquinone contents of mixed dishes, processed meats, soups and cheeses. J Food Compos Anal 16, 595–603.CrossRefGoogle Scholar
Erkkilä, AT, Lichtenstein, AH, Dolnikowski, GG, Grusak, MA, Jalbert, SM, Aquino, KA, Petersen, JW & Booth, SL (2004) Plasma transport of vitamin K in men using deuterium-labeled collard greens. Metabolism 53, 215–221.CrossRefGoogle ScholarPubMed
Federal, Register (2003) Food labeling: trans fatty acids in nutrition labeling, nutrient content claims, and health claims. Final rule. pp. 41433–41506. Food and Drug Administration, HHS.Google Scholar
Grundy, SM (1998) Hypertriglyceridemia, atherogenic dyslipidemia, and the metabolic syndrome. Am J Cardiol 81, 18B–25BCrossRefGoogle ScholarPubMed
Gundberg, CM, Nieman, SD, Abrams, S & Rosen, H (1998) Vitamin K status and bone health: an analysis of methods for determination of undercarboxylated osteocalcin. J Clin Endocrinol Metab 83, 3258–3266.Google ScholarPubMed
Kannel, WB, Feinleib, M, McNamara, PM, Garrison, RJ & Castelli, WP (1979) An investigation of coronary heart disease in families. The Framingham Offspring Study. Am J Epidemiol 110, 281–290.CrossRefGoogle ScholarPubMed
Koivu, T, Piironen, V, Lampi, A-M & Mattila, P (1999) Dihydrovitamin K 1 in oils and margarines. Food Chem 64, 411–414.CrossRefGoogle Scholar
Lamon-Fava, S, Sadowski, JA, Davidson, KW, O'Brien, ME, McNamara, JR & Schaefer, EJ (1998) Plasma lipoproteins as carriers of phylloquinone (vitamin K 1 ) in humans. Am J Clin Nutr 67, 1226–1231.CrossRefGoogle ScholarPubMed
Lichtenstein, AH, Ausman, LM, Jalbert, SM & Schaefer, EJ (1999) Effects of different forms of dietary hydrogenated fats on serum lipoprotein cholesterol levels. N Engl J Med 340, 1933–1940.CrossRefGoogle ScholarPubMed
McKeown, NM, Jacques, PF, Gundberg, CM, Petersen, JW, Tucker, KL, Kiel, DP, Wilson, PW & Booth, SL (2002) Dietary and nondietary determinants of vitamin K biochemical measures in men and women. J Nutr 132, 1329–1334.CrossRefGoogle ScholarPubMed
McNamara, JR & Schaefer, EJ (1987) Automated enzymatic standardized lipid analyses for plasma and lipoprotein fractions. Clin Chim Acta 166, 1–8.CrossRefGoogle ScholarPubMed
Mensink, RP & Katan, MB (1990) Effect of dietary trans fatty acids on high-density and low-density lipoprotein cholesterol levels in healthy subjects. N Engl J Med 323, 439–445.CrossRefGoogle ScholarPubMed
National Cholesterol Education Program (NCEP) Expert Panel (2002) Detection, evaluation, and treatment of high blood cholesterol in adults (Adult Treatment Panel III) final report. Circulation 106, 3143–3421.CrossRefGoogle Scholar
Peterson, JW, Muzzey, KL, Haytowitz, DB, Exler, J, Lemar, L & Booth, SL (2002) Phylloquinone (vitamin K 1 ) and dihydrophylloquinone content of fats and oils. JAOCS 79, 641–646.CrossRefGoogle Scholar
Rimm, EB, Giovannucci, EL, Stampfer, MJ, Colditz, GA, Libin, LB & Willett, WC (1992) Reproducibility and validity of an expanded self-administered semiquantitative food frequency questionnaire among male health professionals. Am J Epidemiol 135, 1114–1126.CrossRefGoogle ScholarPubMed
Sokoll, LJ & Sadowski, JA (1996) Comparison of biochemical indexes for assessing vitamin K nutritional status in a healthy adult population. Am J Clin Nutr 63, 566–573.CrossRefGoogle Scholar
Traber, MG & Jialal, I (2000) Measurement of lipid-soluble vitamins – further adjustment needed?. Lancet 355, 2013–2014.CrossRefGoogle ScholarPubMed
Willett, WC, Sampson, L, Stampfer, MJ, Rosner, B, Bain, C, Witschi, J, Hennekens, CH & Speizer, FE (1985) Reproducibility and validity of a semiquantitative food frequency questionnaire. Am J Epidemiol 122, 51–65.CrossRefGoogle ScholarPubMed