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Dental and metabolic effects of lactitol in the diet of laboratory rats

Published online by Cambridge University Press:  09 March 2007

T. H. Grenby  and
A. Phillips
T. H. Grenby
Affiliation:
Department of Oral Medicine and Pathology, United Medical and Dental Schools, Guy's Hospital, LondonSEI 9RT
A. Phillips
Affiliation:
Department of Oral Medicine and Pathology, United Medical and Dental Schools, Guy's Hospital, LondonSEI 9RT
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Abstract

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1. Because so little is known about the properties of lactitol as a possible alternative bulk sweetener to sucrose, it was tested in two large-scale experiments in laboratory rats. Matched groups of caries-active Osborne-Mendel rats were fed on uniform diets containing lactitol and compared with a sucrose control in both experiments, plus a xylitol control in the first experiment.

2. In the early stages of the experiments weight gains and food utilization were better on the sucrose than on the lactitol regimens. Body-fat storage was higher on the sucrose than on the polyol regimens.

3. At the end of 8 weeks the mandibular molars were examined for dental plaque accumulation and dental caries. The dental caries scores when 160 g sucrose/kg in the diet was replaced by lactitol were lower by a highly significant margin, bringing them down to the same low level as those on a 160 g xylitol/kg regimen.

4. Testing lactitol in a manufactured food product, shortbread biscuits, in comparison with ordinary sucrose biscuits, showed differences in plaque scores (significant) and caries levels (highly significant), with 60% fewer lesions on the lactitol regimen.

5. The results confirm the low cariogenic potential of lactitol, but show metabolic differences compared with sucrose.

Type
Nutrient Substitutes
Information
British Journal of Nutrition , Volume 61 , Issue 1 , January 1989 , pp. 17 - 24
Copyright
Copyright © The Nutrition Society 1989

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