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Decrease in amylase (EC 3.4.21.4) synthesis in lactating rats

Published online by Cambridge University Press:  09 March 2007

Junji Mizoguchi  and
Tomonori Imamichi
Junji Mizoguchi
Affiliation:
Hatano Research Institute Food and Drug Safety Centre, 729–5 Ochiai, Hadano, Kanagawa 257, Japan
Tomonori Imamichi
Affiliation:
Department of Physiology, Nippon Veterinary and Zootechnical College, Kyonan-cho, Musashino, Tokyo 180, Japan
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Abstract

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1. The amylase (EC 3.4.21.4) and trypsin (EC 3.2.1.1) activities in the pancreas in rats during pregnancy, lactation and after the weaning period, and the secretory responses to a secretagogue (caerulein) in the exocrine pancreas of lactating rats were measured.

2. Trypsin activity increased as lactation progressed and reached twice that of unmated rats in the second half of the lactation period. The amylase activity fell before parturition and failed to recover even after the start of lactation and was significantly decreased throughout the lactation period.

3. The total amount of pancreatic juice produced in the lactating rats was significantly greater than that of unmated rats; the amylase output was significantly less than that of unmated rats.

4. When the pups were removed, amylase activity in the pancreas returned to the value in unmated rats. Furthermore, the amylase activity in lactating rats receiving a daily injection of insulin significantly exceeded that of normal lactating rats.

5 These results indicate that the decrease in amylase activity in lactating rats is due to the reduction of amylase synthesis and there is a possibility that insulin is required for normal or elevated rates of amylase synthesis in lactating rats.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 57 , Issue 2 , March 1987 , pp. 291 - 299
Copyright
Copyright © The Nutrition Society 1987

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