Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-25T01:00:17.918Z Has data issue: false hasContentIssue false
  • English
  • Français

Cross-over study of the influence of bicarbonate-rich mineral water on urinary composition in comparison with sodium potassium citrate in healthy male subjects

Published online by Cambridge University Press:  09 March 2007

Torsten Keßler  and
Albrecht Hesse
Torsten Keßler*
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
Albrecht Hesse
Affiliation:
Division of Experimental Urology, Department of Urology, University of Bonn, Sigmund-Freud-Str. 25, 53105 Bonn, Germany
*
*Corresponding author: Dr Torsten Keßler, fax +49 228 287 6344, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

Urine volume is the greatest risk factor for nephrolithiasis. High fluid intake is the first general advice given to stone-forming patients for the prevention of their recurrence. The aim of the present study was to evaluate the influence of bicarbonate-rich mineral water (1715 mg bicarbonate/l) on urinary-stone risk factors in comparison with sodium potassium citrate, a well-established treatment for urinary stones. The mineral water and sodium potassium citrate were administered in equimolar concentrations, with respect to the alkali load. All investigations were carried out in healthy male subjects aged 23–38 years. The study followed a cross-over design. All subjects received a standardized diet during the cross-over phase, which was formulated according to the dietary recommendations of the German Society of Nutrition (). On the loading day of the cross-over phase, fruit tea was substituted for either mineral water or sodium potassium citrate dissolved in fruit tea. The treatment offered during the second part of the cross-over phase was continued for a 4-week follow-up under normal dietary conditions. During the cross-over phase, there was a significant increase in urinary pH (P<0·001). There was also a significant increase in the excretion of citric acid (P<0·01), a decrease in the excretion of oxalic acid, and therefore a decrease in the relative supersaturations for calcium oxalate and uric acid. In the follow-up phase also, the relative supersaturations decreased and there were beneficial effects on the other urinary variables. The effect of the bicarbonate-rich mineral water was similar to that of the sodium potassium citrate, which suggests that it could be useful in the prevention of the recurrence of calcium oxalate and uric acid stones.

Keywords

Mineral waterCalcium oxalateUric acid
Type
Research Article
Information
British Journal of Nutrition , Volume 84 , Issue 6 , December 2000 , pp. 865 - 871
Copyright
Copyright © The Nutrition Society 2000

References

Barcelo, P, Wuhl, O, Servitge, E, Rousad, A & Pak, CYC (1993) Randomized double-blind study of potassium citrate in idiopathic hypocitraturic calcium nephrolithiasis. Journal of Urology 150, 1761–1764.CrossRefGoogle ScholarPubMed
Borghi, L, Meschi, T, Amato, F, Briganti, A & Giannini, A (1996) Urinary volume, water and recurrences in idiopathic calcium nephrolithiasis: a 5-year randomized prospective study. Journal of Urology 155, 829–843.CrossRefGoogle ScholarPubMed
Consensus Conference (1988) Prevention and treatment of kidney stones. Journal of the American Medical Association 260, 977–981.CrossRefGoogle Scholar
Deutsche Gesellschaft fü Ernährung (1996) In Empfehlungen für die Nährstoffzufuhr (Recommendations for Nutrient Intake). Frankfurt, Germany: Deutsche Gesellschaft f¨r Ernährung.Google Scholar
Finlayson, B (1977) Calcium stones: some physical and clinical aspects. In Calcium Metabolism in Renal Failure and Nephrolithiasis 337–382.Google Scholar
Hesse, A & Bach, D (editors) (1982) Harnsteine: Pathobiochemie und Klinisch-chemische Diagnostik (Urinary stones: Pathobiochemical and Clinical Chemical Diagnostics). Stuttgart and New York: Thieme Verlag.Google Scholar
Hesse, A & Siener, R (1997) Current aspects of epidemiology and nutrition in urinary stone disease. World Journal of Urology 15, 165–171.CrossRefGoogle ScholarPubMed
Hesse, A, Siener, R, Heynck, H & Jahnen, A (1993) The influence of dietary factors on the risk of urinary stone formation. Scanning Microscopy 7, 1119–1128.Google ScholarPubMed
Hesse, A, Tiselius, HG & Jahnen, A (1997) Urinary Stones. Diagnosis, Treatment, and Prevention of Recurrence. Basel: Karger.Google Scholar
Hönow, R, Bongartz, D & Hesse, A (1997) An improved HPLC-enzyme-reactor method for the determination of oxalic acid in complex matrices. Clinica Chimica Acta 261, 131–139.CrossRefGoogle ScholarPubMed
Pak, CYC, Sakhaee, K, Crowther, C & Brinkley, L (1980) Evidence justifying a high fluid intake in treatment of nephrolithiasis. Annals of Internal Medicine 93, 36–39.CrossRefGoogle ScholarPubMed
Parivar, F, Low, RK & Stoller, ML (1996) The influence of diet on urinary stone disease. Journal of Urology 155, 432–440.CrossRefGoogle ScholarPubMed
Rodgers, A (1997) Effect of mineral water containing calcium and magnesium on calcium oxalate urolithiasis risk factors. Urologia Internationalis 58, 93–99.CrossRefGoogle ScholarPubMed
Rodgers, A (1999) Effect of cola consumption on urinary biochemical and physicochemical risk factors associated with calcium oxalate urolithiasis. Urological Research 27, 77–81.CrossRefGoogle ScholarPubMed
Sakhaee, K, Nicar, M, Hill, K & Pak, CYC (1983) Contrasting effects of potassium citrate and sodium citrate therapies on urinary chemistries and crystallization of stone-forming salts. Kidney International 24, 348–352.CrossRefGoogle ScholarPubMed
Simpson, DP (1983) Citrate excretion: a window on renal metabolism. American Journal of Physiology 244, F223–F234.Google ScholarPubMed
Tiselius, HG (1997) Risk formulas in calcium oxalate urolithiasis. World Journal of Urology 15, 176–185.CrossRefGoogle ScholarPubMed
Trinchieri, A (1996) Epidemiology of urolithiasis. Archivio Italiano di Urologia e Andrologia 68, 203–249.Google ScholarPubMed
Vahlensieck, W (1986) Review: The importance of diet in urinary stones. Urological Research 14, 283–288.CrossRefGoogle ScholarPubMed
Wabner, CL & Pak, CYC (1993) Effect of orange juice consumption on urinary stone risk factors. Journal of Urology 149, 1405–1408.CrossRefGoogle ScholarPubMed
Weiss, GH, Sluss, PM & Linke, CA (1992) Changes in urinary magnesium, citrate, and oxalate levels due to cola consumption. Urology 39, 331–333.CrossRefGoogle ScholarPubMed
Werness, PG, Brown, CM, Smith, LH & Finlayson, B (1985) Equil 2: a basic computer program for the calculation of urinary saturation. Journal of Urology 134, 1242–1244.CrossRefGoogle Scholar