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Comparison of urinary 5-L-oxoproline (L-pyroglutamate) during normal pregnancy in women in England and Jamaica

Published online by Cambridge University Press:  09 March 2007

Alan A Jackson ,
Chandarika Persaud ,
Geoff Werkmeister ,
Irene S. M McClelland ,
Asha Badaloo  and
Terrence Forrester
Alan A Jackson
Affiliation:
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX
Chandarika Persaud
Affiliation:
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX
Geoff Werkmeister
Affiliation:
Department of Obstetrics and Gynaecology, University of Southampton, Princess Anne Hospital, Coxford Road, Southampton SO16 5YA
Irene S. M McClelland
Affiliation:
Institute of Human Nutrition, University of Southampton, Bassett Crescent East, Southampton SO16 7PX
Asha Badaloo
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica
Terrence Forrester
Affiliation:
Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston 7, Jamaica
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Abstract

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Urinary 5-L-oxoproline was measured during normal pregnancies in Southampton, England and Kingston, Jamaica. The CV of 5-L-oxoproline excretion in urine, determined over 7 d in a non-pregnant woman and three pregnant women, was 10–36%. Compared with non-pregnant women, urinary 5-L-oxoproline increased three to four times from early pregnancy in women in Southampton, a highly significant difference, and remained elevated at similar levels during mid and late pregnancy. For women in Kingston, the excretion of 5-L-oxoproline was similar to that of Southampton women in the non-pregnant group and during early pregnancy. However, there was a progressive increase in the excretion of 5-L-oxoproline as pregnancy advanced and by late pregnancy excretion was from three to ten times greater than the average for the non-pregnant women. There was a significant difference between the women in Southampton and the women in Kingston during mid and late pregnancy, with women in Kingston excreting twice as much 5-L-oxoproline during late pregnancy. If the excretion of 5-L-oxoproline is a measure of glycine insdciency, the results would indicate that in some pregnancies the ability of the mother to provide glycine for herself and the developing fetus is marginal or inadequate and the constraint appears more marked in Jamaica than in England.

Keywords

Glycine5-L-OxoprolineAmino acidsPregnancy
Type
Human and Clinical Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 2 , February 1997 , pp. 183 - 196
Copyright
Copyright © The Nutrition Society 1997

References

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