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Cholecalciferol supplementation alters gut function and improves digestibility in an underground inhabitant, the naked mole rat (Heterocephulus gluber), when fed on a carrot diet

Published online by Cambridge University Press:  09 March 2007

Shlomo Yahav  and
Rochelle Buffenstein
Shlomo Yahav
Affiliation:
MRC Mineral Metabolism Research Unit, Department of Paediatrics, University of the Witwatersrand, Baragwanath Hospital, Johannesburg, PO Bertsham 2013, South Africa
Rochelle Buffenstein
Affiliation:
Physiology Department, University of the Witwatersrand, Medical School, 7 York Road, Parktown, Johannesburg 2193, South Africa
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Abstract

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Naked mole rats (Heterocephalus glaber) lead a strictly subterranean existence and appear to be naturally deficient in cholecalciferol (D3). Oral supplementation with D3 (Ds) led to a 1.8-fold increase in food intake and the associated enlargement (1.4-fold) of the caecum. The effect of Ds, and the concomitant increase in food intake, on caecal fermentation efficiency when animals were fed on a carrotbased diet was determined by measuring the rate of both gas production and short-chain fatty acid (SCFA) production. Microbial-controlled fermentation processes in the caecum were enhanced with Ds when compared with animals not receiving a D3 supplement (Dn). Both the rates of gas production (Dn 10.76 (SE 0.77), Ds 15.20 (SE 1.77) ml/g dry matter (DM) per h) and SCFA production (Dn 463.0 (SE 33.7), Ds 684.3 (SE 74.8) μmol/g DM per h) increased more than 1.4-fold per g DM caecal substrate. These factors contributed to the higher digestibility of the food in Ds animals. The larger quantity of energy available to D3-replete naked mole rats was not used in anabolic processes, for these animals maintained mass. These findings suggest that metabolic rate in D3-replete animals was elevated. Thus, despite improved gut function, D3-replete animals may be disadvantaged by their higher energy and food requirements in their natural milieu.

Keywords

CholecalciferolCaecal fermentationMole rats
Type
Vitamin Metabolism
Information
British Journal of Nutrition , Volume 69 , Issue 1 , January 1993 , pp. 233 - 241
Copyright
Copyright © The Nutrition Society 1993

References

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