Hostname: page-component-cd9895bd7-gbm5v Total loading time: 0 Render date: 2024-12-25T02:49:15.309Z Has data issue: false hasContentIssue false

Changes with malnutrition in the concentration of plasma vitamin D binding protein in growing rats

Published online by Cambridge University Press:  09 March 2007

Christopher J. Laing*
Affiliation:
Faculty of Veterinary Science, University of Sydney 2006, Australia
David R. Fraser
Affiliation:
Faculty of Veterinary Science, University of Sydney 2006, Australia
*
*Corresponding author:Dr Christopher J. Laing, present address, Department of Genetics, 760 Clinical Research Building, University of Pennsylvania, 415 Curie Boulevard, Philadelphia, PA 19104-6144, USA, fax +1 215 573 5809, email [email protected]
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

The work presented here examines the possible effects of nutritional deficiencies on the characteristics of the plasma transport protein for vitamin D and its metabolites (vitamin D binding protein, DBP) in the growing rat. Deficiencies in both dietary protein intake and dietary energy intake may decrease the concentration of DBP in the circulation, although plasma DBP was not affected by dietary Ca deficiency. None of the dietary factors examined appears to influence the affinity of DBP for its major ligand, 25-hydroxycholecalciferol (25(OH)D3). Protein-deficient rats seemed to have difficulty in maintaining adequate concentrations of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) in the circulation. The sensitivity of DBP to dietary protein and energy intake may constitute a novel mechanism that may help to explain the observed associations between malnutrition and the development of metabolic bone disease, through alterations to the cellular availability of vitamin D ligands to DBP.

Type
Research Article
Copyright
Copyright © The Nutrition Society 2002

References

Akpede, GO, Omotara, BA & Ambe, JP (1999) Rickets and deprivation: a Nigerian study. Journal of the Royal Society of Health 119, 216222.CrossRefGoogle ScholarPubMed
Blomhoff, R, Green, MH, Green, JB, Berg, T & Norum, KR (1991) Vitamin A metabolism: new perspectives on absorption, transport and storage. Physiological Reviews 71, 951990.CrossRefGoogle ScholarPubMed
Bouillon, R, Van Baelen, H & DeMoor, P (1977 a) 25-Hydroxyvitamin D and its binding protein in maternal and cord serum. Journal of Clinical Endocrinology and Metabolism 45, 679684.CrossRefGoogle ScholarPubMed
Bouillon, R, Verstuyf, A, Zhao, J, Tan, B & Van Baelen, H (1996) Nonhypercalcemic vitamin D analogs: interactions with the vitamin D-binding protein. Hormone Research 45, 117121.CrossRefGoogle ScholarPubMed
Bradford, MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry 72, 248254.CrossRefGoogle ScholarPubMed
Brissenden, J & Wilson Cox, D (1978) Electrophoretic and quantitative assessment of vitamin D-binding protein (group specific component) in inherited rickets. Journal of Laboratory and Clinical Medicine 91, 455462.Google ScholarPubMed
Clements, MR, Johnson, L & Fraser, DR (1987) A new mechanism for induced vitamin D deficiency in calcium deprivation. Nature 324, 6265.CrossRefGoogle Scholar
Coon, WW & Iob, VL (1964) The liver and protein metabolism. In The Liver and Portal Hypertension, pp. 127151 [Child, C, editor]. Philadelphia, PA: WB Saunders.Google Scholar
Fraser, DR & Emtage, JS (1976) Vitamin D in the avian egg. Its molecular identity and mechanism of incorporation into yolk. Biochemical Journal 160, 671682.CrossRefGoogle ScholarPubMed
Gregoriadis, G (1975) Catabolism of glycoproteins. In Lysosomes in Biology and Pathology, pp. 265294 [Dingle, J and Dean, JT, editors]. Amsterdam: North Holland Publishing Company.Google Scholar
Haddad, JG, Fraser, DR & Lawson, DEM (1981) Vitamin D binding protein. Turnover and fate in the rabbit. Journal of Clinical Investigation 67, 15501560.CrossRefGoogle ScholarPubMed
Halloran, BP, Bikle, DD, Levens, MJ, Castro, ME, Globus, RK & Holton, E (1986) Chronic 1,25-dihydroxyvitamin D3 administration in the rat reduces the serum concentration of 25-hydroxyvitamin D by increasing metabolic clearance rate. Journal of Clinical Investigation 78, 622628.CrossRefGoogle ScholarPubMed
Hay, A & Watson, G (1976) The plasma transport proteins of 25-hydroxycholecalciferol in fish, amphibians, reptiles, and birds. Comparative Biochemistry and Physiology 53B, 167172.Google Scholar
Hoffenberg, R (1972) Measurement of the synthesis of liver-produced plasma proteins with special reference to their regulation by dietary protein and amino acid supply. Proceedings of the Nutrition Society 31, 265272.CrossRefGoogle ScholarPubMed
Jacobs, R & Ray, R (1968) Studies of vitamin D binding in normal and rachitic serum. Clinical Orthopaedics 56, 275281.CrossRefGoogle ScholarPubMed
Kaysen, GA (1988) Albumin metabolism in the nephrotic syndrome: the effect of dietary protein intake. American Journal of Kidney Diseases 12, 461480.CrossRefGoogle ScholarPubMed
Kirsch, RE & Saunders, SJ (1972) Nutrition and the liver. South African Medical Journal 46, 20722078.Google ScholarPubMed
Kuhn, RW (1988) Corticosteroid-binding globulin interacts with target cells and plasma membranes. Annals of the New York Academy of Sciences 538, 146158.CrossRefGoogle ScholarPubMed
Lichenstein, HS, Lyons, DE, Wurfel, MM, Johnson, DA, McGinley, MD, Leidli, JC, Trollinger, DB, Mayer, JP, Wright, SD & Zukoswki, MM (1994) Afamin is a new member of the albumin, α-fetoprotein, and vitamin D-binding protein gene family. Journal of Biological Chemistry 269, 1814918154.CrossRefGoogle ScholarPubMed
Licht, P (1994) The relation of the dual thyroxine/vitamin D-binding protein (TBP/DBP) of emydid turtles to the vitamin D-binding proteins of other vertebrates. General and Comparative Endocrinology 94, 215224.CrossRefGoogle Scholar
Lulseged, S & Fitwi, G (1999) Vitamin D deficiency rickets: socio-demographic and clinical risk factors in children seen at a referral hospital in Addis Ababa. East African Medical Journal 76, 457461.Google Scholar
Mason, R & Posen, S (1977) Some problems associated with assay of 25-hydroxycholecalciferol in human serum. Clinical Chemistry 23, 806810.CrossRefGoogle Scholar
Mendel, CM (1989) The free hormone hypothesis: a physiologically based mathematical model. Endocrine Reviews 10, 232274.CrossRefGoogle ScholarPubMed
Morgenthaler, JJ & Nydegger, UE (1984) Synthesis, distribution and catabolism of human plasma proteins in plasma exchange. International Journal of Artificial Organs 7, 2734.CrossRefGoogle ScholarPubMed
Pettifor, JM, Bikle, DD, Cavaleros, M, Zachen, D, Kamdar, MC & Ross, FP (1995) Serum levels of free 1,25-dihydroxyvitamin D in vitamin D toxicity. Annals of Internal Medicine 122, 511513.CrossRefGoogle ScholarPubMed
Reinhardt, TA & Hollis, RL (1986) 1,25-dihydroxyvitamin D microassay employing radioreceptor techniques. Methods in Enzymology 123, 176185.CrossRefGoogle ScholarPubMed
Reinholz, GG & DeLuca, HF (1998) Inhibition of 25-hydroxyvitamin D3 production by 1,25-dihydroxyvitamin D3 in rats. Archives of Biochemistry and Biophysics 355, 7783.CrossRefGoogle ScholarPubMed
Rikkers, H & DeLuca, H (1967) An in vivo study of the carrier proteins of 3H-vitamins D3 and D4 in rat serum. American Journal of Physiology 213, 380386.CrossRefGoogle Scholar
Rosner, W (1990) The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocrine Reviews 11, 8091.CrossRefGoogle ScholarPubMed
Rothschild, MA, Oratz, M & Schreiber, SS (1975) Regulation of albumin metabolism. Annual Review of Medicine 26, 91104.CrossRefGoogle ScholarPubMed
Safadi, FF, Thornton, P, Magiera, H, Hollis, BW, Gentile, M, Haddad, JG, Liebhaber, SA & Cooke, NE (1999) Osteopathy and resistance to vitamin D toxicity in mice null for vitamin D binding protein. Journal of Clinical Investigation 103, 239251.CrossRefGoogle ScholarPubMed
Sainz, RD, Calvert, CC & Baldwin, RL (1986) Relationships among dietary protein, feed intake and tissue protein turnover in lactating rats. Journal of Nutrition 116, 18201829.CrossRefGoogle ScholarPubMed
Sakuma, K, Ohyama, T, Sogawa, K, Fujii-Kuriyama, Y & Matsumura, Y (1987) Low protein–high energy diet induces repressed transcription of albumin mRNA in rat liver. Journal of Nutrition 117, 11411148.CrossRefGoogle ScholarPubMed
Seshadri, MS, Frankel, TL, Lissner, D, Mason, RS & Posen, S (1985) Bioactive parathyroid hormone in the rat: effects of calcium and calcitriol. Endocrinology 117, 24172423.CrossRefGoogle ScholarPubMed
Siiteri, PK, Murai, JT, Hammond, GL, Nisker, JA, Raymoure, WJ & Kuhn, RW (1982) The serum transport of steroid hormones. Recent Progress in Hormone Research 38, 457503.Google ScholarPubMed
Soliman, AT, Madina, EH & Morsi, MR (1996) Radiological, biochemical, and hormonal changes in malnourished children with rachitic manifestations. Journal of Tropical Pediatrics 42, 3437.CrossRefGoogle ScholarPubMed
Straus, DS (1994) Nutritional regulation of hormones and growth factors that control mammalian growth. FASEB Journal 8, 612.CrossRefGoogle ScholarPubMed
Swillens, S (1995) Interpretations of binding curves obtained with high receptor concentrations: practical aid for computer analysis. Molecular Pharmacology 47, 11971203.Google ScholarPubMed
Tavill, AS (1972) The synthesis and degradation of liver-produced proteins. Gut 13, 225241.CrossRefGoogle ScholarPubMed
Walter, EA, Scariano, JK, Easington, CR, Polaco, AM, Hollis, BW, Dasgupta, A, Pam, S & Glew, RH (1997) Rickets and protein malnutrition in northern Nigeria. Journal of Tropical Pediatrics 43, 98102.CrossRefGoogle ScholarPubMed
Waterlow, JC, Garlick, PJ & Millward, DJ (1978) Protein Turnover in Mammalian Tissues and in the Whole Body, pp. 4246, 5683, 610616, 711, 715718. Amsterdam: Elsevier/North-Holland Biomedical Press.Google Scholar
Whicher, J & Spence, C (1987) When is serum albumin worth measuring? Annals of Clinical Biochemistry 24, 572580.CrossRefGoogle ScholarPubMed
Woloszczuk, W (1985) Determination of vitamin D binding protein by Scatchard analysis and estimation of a free 25-hydroxy-vitamin D index. Clinica Chimica Acta 145, 2735.CrossRefGoogle ScholarPubMed
Yamamoto, N, Naraparaju, VR & Asbell, SO (1996) Deglycosylation of serum vitamin D3-binding protein leads to immunosuppression in cancer patients. Cancer Research 56, 28272831.Google ScholarPubMed