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Causal associations of tea consumption on risk of pancreatic adenocarcinoma and the mediating role of vascular endothelial growth factor D levels

Published online by Cambridge University Press:  06 November 2024

Yonghao Ouyang Open the ORCID record for Yonghao Ouyang [Opens in a new window] ,
Beini Zhou ,
Lihua Chu ,
Xin Chen ,
Qiang Hao  and
Jiajia Lei
Yonghao Ouyang*
Affiliation:
Research Institute of General Surgery, Jinling Hospital, Nanjing 210000, People’s Republic of China
Beini Zhou
Affiliation:
Jiangxi Modern polytechnic college, Nanchang 330000, People’s Republic of China
Lihua Chu
Affiliation:
Jinggangshan University, Ji’an 3343000, People’s Republic of China
Xin Chen
Affiliation:
Jiangxi University Of Traditional Chinese Medicine, Nanchang 330000, People’s Republic of China
Qiang Hao
Affiliation:
Research Institute of General Surgery, Jinling Hospital, Nanjing 210000, People’s Republic of China
Jiajia Lei
Affiliation:
College of Food Science & Project Engineering, Wuhan Polytechnic University, Wuhan 430023, People’s Republic of China
*
*Corresponding author: Yonghao Ouyang, email 854449245@qq.com
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Abstract

Tea is one of the most widely consumed beverages in the world. However, the association between tea and risk of pancreatic adenocarcinoma remains controversial. This study aimed to investigate the causal relationship between tea consumption and risk of pancreatic adenocarcinoma and to explore their mediating effects. The two-sample Mendelian randomisation (MR) analysis showed an inverse causal relationship between tea intake and pancreatic adenocarcinoma (OR: 0·111 (0·02, 0·85), P < 0·04). To examine the mediating effects, we explored the potential mechanisms by which tea intake reduces the risk of pancreatic adenocarcinoma. Based on the oral bioavailability and drug-like properties in Traditional Chinese Medicine Systems Pharmacology database, we selected the main active ingredients of tea. We screened out the fifteen representative targeted genes by Pharmmapper database, and the gene ontology enrichment analysis showed that these targeted genes were related to vascular endothelial growth factor (VEGF) pathway. The two-step MR analysis of results showed that only VEGF-D played a mediating role, with a mediation ratio of 0·230 (0·066, 0·394). In conclusion, the findings suggest that VEGF-D mediates the effect of tea intake on the risk of pancreatic adenocarcinoma.

Keywords

Mendelian randomisationTea consumptionVascular endothelial growth factorPancreatic adenocarcinomaMediation
Type
Research Article
Information
British Journal of Nutrition , Volume 132 , Issue 11 , 14 December 2024 , pp. 1503 - 1512
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Copyright
© The Author(s), 2024. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work.

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