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Cardiovascular β-adrenoceptor sensitivity of undernourished subjects

Published online by Cambridge University Press:  09 March 2007

M. Prem Jayarajan  and
P. S. Shetty
M. Prem Jayarajan
Affiliation:
Department of Physiology, Nutrition Research Centre (ICMR), St John's Medical College, Bangalore 560 034, India
P. S. Shetty
Affiliation:
Department of Physiology, Nutrition Research Centre (ICMR), St John's Medical College, Bangalore 560 034, India
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Abstract

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1. Eleven normal-weight male subjects (weight/height2 (W/H2) 19.0-225) from a good socio-economic background and on ad lib. food intake, and eight undernourished male labourers (W/H2 16.4–18.6) on low energy intakes, were studied.

2. Comparison of cardiovascular responses to increasing single doses of the β-agonist, isoproterenol, showed a significantly greater positive chronotropic dose response in the undernourished subjects.

3. Cardiovascular responses to head-up tilt were similar in both the normal-weight and undernourished subjects.

4. Undernourished individuals may show an increase in β-adrenoceptor sensitivity which may be akin to a denervation type of supersensitivity as a result of a nutrition-related reduction in sympathetic activity.

Type
Clinical and Human Nutrition papers
Information
British Journal of Nutrition , Volume 58 , Issue 1 , July 1987 , pp. 5 - 11
Copyright
Copyright © The Nutrition Society 1987

References

REFERENCES

Aarons, R. D., Nies, A. S., Gal, J., Hegstrand, L. R. & Molinoff, P. B. (1980). Journal of Clinical Investigation 65, 949–957.CrossRefGoogle Scholar
Arnold, J. M. O. & McDevitt, D. G. (1983). British Journal of Clinical Pharmacology 15, 423–429.CrossRefGoogle Scholar
Bristow, M. R., Ginsberg, R., Minobe, W., Cubicciotti, R. S., Sageman, W. S., Lurie, K., Billingham, M. E., Harrison, D. C. & Stinson, E. B. (1982). New England Journal of Medicine 307, 205–211.CrossRefGoogle Scholar
Chopra, I. J., Chopra, U., Smith, S. R., Reza, M. & Solomon, D. H. (1975). Journal of Clinical Endocrinology and Metabolism 41, 1043–1049.CrossRefGoogle Scholar
Chopra, I. J. & Smith, S. R. (1975). Journal of Clinical Endocrinology and Metabolism 40, 221–227.CrossRefGoogle Scholar
Cleaveland, C. R., Rangno, R. E. & Shand, R. G. (1972). Archives of Internal Medicine 130, 47–52.CrossRefGoogle Scholar
Colucci, W. S., Alexander, R. W., Williams, G. H., Rude, R. E., Holman, B. L., Konstan, M. A., Wynne, J., Mudge, G. H. Jr & Braunwald, E. (1981). New England Journal of Medicine 305, 185–190.CrossRefGoogle Scholar
Crandall, D. L., Lai, M. F., Huggins, F. J., Tanikella, T. K. & Cervoni, P. (1983). American Journal of Physiology 244, H444–H448.Google Scholar
Danforth, E. Jr (1983). American Journal of Clinical Nutrition 38, 1006–1017.CrossRefGoogle Scholar
Davies, B., Sudera, D., Sagnella, G., Marchesi-Saviotti, M., Mathias, C., Bannister, R. & Sever, P. (1982). Journal of Clinical Investigation 69, 779–784.CrossRefGoogle Scholar
Dunlop, D. & Shanks, R. G. (1968). British Journal of Pharmacology and Chemotherapy 32, 201–218.CrossRefGoogle Scholar
Durnin, J. V. G. A. & Womersley, J. (1974). British Journal of Nutrition 32, 77–92.CrossRefGoogle Scholar
Fraser, J., Nadeau, J., Robertson, D. & Wood, A. J. J. (1981). Journal of Clinical Investigation 67, 1777–1784.CrossRefGoogle Scholar
George, C. F., Conolly, M. E., Fenyvesi, T., Briant, R. & Dollery, C. T. (1972). Archives of Internal Medicine 130, 361–364.CrossRefGoogle Scholar
Gerber, J. G. & Nies, A. S. (1979). New England Journal of Medicine 301, 1234–1235.CrossRefGoogle Scholar
Ginsberg, A. M., Clutter, W. E., Shah, S. D. & Cryer, P. E. (1981). Journal of Clinical Investigation 67, 1785–1791.CrossRefGoogle Scholar
Jung, R. T., Shetty, P. S., Barrand, M. A., Callingham, B. A. & James, W. P. T. (1979). British Medical Journal i, 12–13.CrossRefGoogle Scholar
Lefkowitz, R. J., Caron, M. G. & Stiles, G. L. (1984). New England Journal of Medicine 310, 1570–1579.Google Scholar
Motulsky, H. J. & Insel, P. A. (1982). New England Journal of Medicine 307, 18–29.CrossRefGoogle Scholar
Shetty, P. S. (1984). Human Nutrition: Clinical Nutrition 38C, 443–451.Google Scholar
Shetty, P. S. & Jayarajan, M. P. (1987). Proceedings of the VI Annual Conference of the Indian Association of Biomedical Scientists (In the Press).Google Scholar
Shetty, P. S., Jung, R. T. & James, W. P. T. (1979). Lancet i, 77–79.CrossRefGoogle Scholar
Williams, L. T., Lefkowitz, R. J., Watanabe, A. M., Hathway, D. R. & Besch, H. R. (1977). Journal of Biological Chemistry 252, 2787–2789.CrossRefGoogle Scholar
Young, J. B. & Landsberg, L. (1977 a). Nature 269, 615–617.CrossRefGoogle Scholar
Young, J. B. & Landsberg, L. (1977 b). Science 196, 1473–1475.CrossRefGoogle Scholar
Young, J. B. & Landsberg, L. (1979). American Journal of Physiology 236, E524–E533.Google Scholar