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Bioavailability of magnesium and calcium from cow's milk and soya-bean beverage in rats

Published online by Cambridge University Press:  09 March 2007

Elizabeth J. Brink ,
Pieter R. Dekker ,
Emerentia C. H. Van Beresteijn  and
Anton C. Beynen
Elizabeth J. Brink
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Pieter R. Dekker
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Emerentia C. H. Van Beresteijn
Affiliation:
Department of Nutrition, Netherlands Institute for Dairy Research, PO Box 20, 6710 BA Ede, The Netherlands
Anton C. Beynen
Affiliation:
Department of Laboratory Animal Science, State University, PO Box 80.166, 3508 TD Utrecht, The Netherlands Department of Human Nutrition, Agricultural University, PO Box 8129, 6700 EV Wageningen, The Netherlands
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Abstract

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The milk components lactose and casein enhance the apparent absorption of magnesium and possibly also of calcium, whereas phytate, which occurs in soya-bean products, has an inhibitory effect. This implies that soya-bean beverage v. cow's milk could lower bioavailability of Mg and Ca. This hypothesis was tested in two experiments with growing rats. Feeding soya-bean beverage v. cow's milk consistently lowered body-weight gain, enhanced bone turnover, as measured by increased plasma alkaline phosphatase (EC 3.1.3.1) activity and increased urinary hydroxyproline excretion, and decreased Mg and Ca concentrations in the femur. Because the mineral compositions of the soya-bean beverage and the cow's milk were different, the intake of Mg was higher in rats fed on soya-bean beverage, whereas that of Ca was higher in rats fed on cow's milk. Supplementation of the soya-bean beverage either with phosphorus and Ca or with P, Ca and methionine, to concentrations identical to those in milk, restored growth and bone mineralization. When using diets carefully balanced for Mg, Ca, P, sodium, potassium and methionine, soya-bean beverage v. cow's milk in the diets decreased apparent absorption and urinary excretion of Mg and Ca. Hydrolysis of lactose in milk decreased absorption and urinary excretion of Mg; it did not significantly affect Ca absorption but lowered urinary Ca excretion. The present study shows that soya-bean beverage v. milk depresses Mg and Ca bioavailability, as would be predicted on the basis of reported effects of their purified components.

Keywords

Cow's milkSoya-bean beverageMineral bioavailabilityRats
Type
Mineral Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 271 - 282
Copyright
Copyright © The Nutrition Society 1992

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