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Binding of zinc and calcium to inositol phosphates (phytate) in vitro

Published online by Cambridge University Press:  09 March 2007

C. J. Simpson  and
A. Wise
C. J. Simpson
Affiliation:
Robert Gordon's Institute of Technology, Queen's Road, Aberdeen AB9 2PG
A. Wise
Affiliation:
Robert Gordon's Institute of Technology, Queen's Road, Aberdeen AB9 2PG
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Abstract

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Inositol compounds with three to five phosphate groups (IP3–IP5) were produced by hydrolysis of phytate (inositol hexaphosphate, IP6) and their binding affinities for calcium and zinc investigated at neutral pH with relative concentrations that had been found in a range of students' meals. Zn solubility was negligible at many of these concentrations, with less Zn bound to precipitates of Ca-IP6 than Ca-IP5. The capacity to precipitate Zn at these ratios fell between IP5 and IP3. Zn was partially desorbed by soluble chelators (histidine and picolinate), especially when it had been adsorbed to preformed Ca-IP precipitates. A lower proportion of Zn was accessible to soluble chelators from Ca-IP4 than the other compounds. IP3-IP4 were hydrolysed. by phytase more readily than IP5–IP6.

Keywords

ZincCalciumInositol phosphates
Type
Micronutrients
Information
British Journal of Nutrition , Volume 64 , Issue 1 , July 1990 , pp. 225 - 232
Copyright
Copyright © The Nutrition Society 1990

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