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Aversion-preference patterns in amino acid- or protein-deficient rats: a comparison with previously reported responses to thiamin-deficient diets

Published online by Cambridge University Press:  09 March 2007

Gilles Fromentin ,
Dorothy W. Gietzen  and
Stylianos Nicolaidis
Gilles Fromentin
Affiliation:
Laboratoire de neurobiologie des régulations, CNRS UPR 9054, Collège de France, 11 place Marcellin Berthelot, F75231 Paris cedex 05, France
Dorothy W. Gietzen
Affiliation:
Department of Anatomy, Physiology and Cell Biology, School of Veterinary Medicine and Food Intake Laboratory, University of California, Davis, CA 95616, USA
Stylianos Nicolaidis
Affiliation:
Laboratoire de neurobiologie des régulations, CNRS UPR 9054, Collège de France, 11 place Marcellin Berthelot, F75231 Paris cedex 05, France
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Abstract

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The purpose of the present experiments was to extend previous data on the strategy used by adult rats to select feed appropriately when faced with diets devoid of protein or an essential amino acid (EAA), and to compare this strategy with that used when facing vitamin (thiamin) deficiency. Rats fed on either balanced or deficient (EAA or protein) diets were offered a choice between a novel deficient and a familiar (deficient or corrected) diet and their choice was monitored. It was shown that protein- and EAA-deficient rats acquired an aversion for their corresponding familiar devoid diet, which by itself promoted a neophilia for the novel diet. This neophilia was not non-specific because protein-deficient rats facing a choice between a protein-devoid and an EAA-devoid diet did exhibit neophilia but only in the short term (less than 5h), and then switched to a preference for the familiar protein-devoid diet. These results show that, in contrast to the case of vitamin deficiency, the protein- or EAA-devoid diet-induced neophilia can be rapidly reversed if the novel feed happens to be more deleterious than the familiar, inappropriate one. This behaviour suggests the existence of sensitive mechanisms able to reveal within a short time the EAA inadequacy of the ingested feed and to adapt the choice for the most appropriate feeds more promptly than in the face of thiamin deficiency. Thus it appears that balancing EAA is more urgent than balancing thiamin.

Keywords

Dietary choiceNutrient-preferenceConditioned taste aversionThiaminSpecific appetites
Type
General Nutrition
Information
British Journal of Nutrition , Volume 77 , Issue 2 , February 1997 , pp. 299 - 314
Copyright
Copyright © The Nutrition Society 1997

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