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An animal model to study iron availability from human diets

Published online by Cambridge University Press:  13 December 2007

B. S. Narasinga Rao ,
J. Siva Prasad  and
C. Vijaya Sarathy
B. S. Narasinga Rao
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad-500 007, India
J. Siva Prasad
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad-500 007, India
C. Vijaya Sarathy
Affiliation:
National Institute of Nutrition, Indian Council of Medical Research, Hyderabad-500 007, India
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Abstract

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1. The retention of ferric- and ferrous-iron was determined in guinea-pigs and monkeys using 55Fe and 59Fe.

2. The bioavailability of Fe from two typical Indian diets based on rice and wheat was determined in humans and monkeys using a 59Fe tracer and whole-body counting.

3. The retention ratio, ferric-Fe; ferrous-Fe was 0.90 in guinea-pigs and 0.33 in monkeys, indicating that monkeys absorb ferrous-Fe preferentially.

4. In monkeys retention of Fe from the test diets, as from ferrous ascorbate was lower than that in humans.

5. When food-Fe retention was expressed in relation to inorganic-Fe retention the value for retention ratio, food Fe: inorganic Fe in monkeys was similar to that in human subjects.

6. The results indicate that the monkey can be used as a model to study Fe absorption from human diets.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 37 , Issue 3 , May 1977 , pp. 451 - 456
Copyright
Copyright © The Nutrition Society 1977

References

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