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An abnormality of the bone marrow associated with vitamin E deficiency in sheep

Published online by Cambridge University Press:  25 March 2008

R. J. Kimber  and
Shirley H. Allen
R. J. Kimber
Affiliation:
Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia
Shirley H. Allen
Affiliation:
Institute of Medical and Veterinary Science, Frome Road, Adelaide, South Australia 5000, Australia
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Abstract

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1. Sheep fed on a maintenance ration of wheaten-hay chaff or of wheaten-hay chaff–lucerne-hay chaff (1:1, w/w) became deficient or incipiently deficient in vitamin E.

2. Degenerative changes were observed in bone marrow and muscle, and liver function was impaired in some animals. These abnormalities were not influenced by the vitamin B12 status of the animals or by a shortage of cobalt in the rumen.

3. Plasma ascorbic acid levels may not have been optimum, and folic acid may not have been fully utilized by some sheep.

4. Liver function responded fairly rapidly to α-tocopheryl acetate, but skeletal muscle had not returned to normal after 28 weeks of treatment. A variable trend towards normal cellularity was found in bone marrow following supplementation with α-tocopheryl acetate.

5. A secondary deficiency or, alternatively, inefficient excretion or metabolism of a toxic material, may occur in vitamin E deficiency as a result of degenerative changes in the absorptive or excretory areas of the intestinal tract and be responsible for the bone marrow abnormality.

Type
General Nutrition
Information
British Journal of Nutrition , Volume 33 , Issue 3 , May 1975 , pp. 357 - 371
Copyright
Copyright © The Nutrition Society 1975

References

Alderson, N. E., Mitchell, G. E. Jr, Little, C. O., Warner, R. E. & Tucker, R. E. (1971). J. Nutr. 101, 655.CrossRefGoogle Scholar
Allen, S. H. (1956). Biochem. J. 63, 461.CrossRefGoogle Scholar
Babson, A. L., Shapiro, P. O., Williams, P. A. R. & Phillips, G. E. (1962). Clinica chim. Acta 7, 199.CrossRefGoogle Scholar
Baker, H., Herbert, V., Frank, O., Pasher, I., Hutner, S. H., Wasserman, L. R. & Sobotka, H. (1959). Clin. Chem. 5, 275.CrossRefGoogle Scholar
Brown, R. G., Sharp, B. A., Young, L. G. & Van Dreumel, A. (1971). Can. J. Anim. Sci. 51, 537.CrossRefGoogle Scholar
Carpenter, M. P. (1967). Fedn Proc. Fedn Am. Socs exp. Biol. 26, 475.Google Scholar
Cawthorne, M. A., Bunyan, J., Sennitt, M. V., Green, J. & Grasso, P. (1970). Br. J. Nutr. 24, 357.CrossRefGoogle Scholar
Coffman, J. R. & Garner, H. E. (1972). J. Am. vet. med. Ass. 161, 1280.Google Scholar
Crane, F. L. & Barr, R. (1971). Meth. Enzym. 18C, 137.CrossRefGoogle Scholar
Dawbarn, M. C., Hine, D. C. & Smith, J. (1957). Aust.J. exp. Biol. med. Sci. 35, 273.CrossRefGoogle Scholar
Diplock, A. T. & Haslewood, G. A. D. (1967). Biochem. J. 104, 1004.CrossRefGoogle Scholar
Dooley, P. C., Hecker, J. F. & Webster, M. E. D. (1972). Aust. J. exp. Biol. med. Sci. 50, 745.CrossRefGoogle Scholar
Edgar, J. A. (1969). Experientia 25, 1214.CrossRefGoogle Scholar
Fleck, A. & Morrison, B. A. (1970). Clinica chim. Acta 30, 751.CrossRefGoogle Scholar
Folkers, K. (1969). Int. Z. VitamForsch. 39, 334.Google Scholar
Gourlay, G. K., Savage, J. & Stock, B. H. (1975). Aust. J. pharm. Sci. (In the Press.)Google Scholar
Hansen, L. G. & Warwick, W. J. (1966). Am. J. clin. Path. 46, 133.CrossRefGoogle Scholar
Hemming, F. W. & Pennock, J. F. (1965). In Biochemistry of Quinones p. 287 [Morton, R. A., editor]London and New York: Academic Press.Google Scholar
Hochella, N. J. & Weinhouse, S. (1965). Analyt. Biochem. 13, 322.CrossRefGoogle Scholar
Hoffman, W. S. (1970). The Biochemistry of Clinical Medicine 4th ed., p. 795. Chicago: Year Book Medical Publishers Inc.Google Scholar
Hogan, J. P., Weston, R. H. & Lindsay, J. R. (1968). Aust. J. biol. Sci. 21, 1263.CrossRefGoogle Scholar
Ibbotson, R. N., Allen, S. H. & Gurney, C. W. (1970). Aust. J. exp. Biol. med. Sci. 48, 161.CrossRefGoogle Scholar
Imami, R. H., Reiser, S. & Christiansen, P. A. (1970). J. Nutr. 100, 101.CrossRefGoogle Scholar
Jáuregui-Adell, J. (1966). Adv. Protein Chem. 21, 387.CrossRefGoogle Scholar
Jeffery, E. H. & Diplock, A. T. (1972). Biochem. J. 130, 12P.CrossRefGoogle Scholar
Mapson, L. W. (1967). In The Vitamins Vol. 1, 2nd ed., p. 369 [Sebrell, W. H. Jr and Harris, R. S., editors]New York and London: Academic Press.Google Scholar
Marston, H. R. (1970). Br. J. Nutr. 24, 615.CrossRefGoogle Scholar
Mervyn, L. & Morton, R. A. (1959). Biochem. J. 72, 106.CrossRefGoogle Scholar
Nair, P. P., Mezey, E., Murty, H. S., Quartner, J. & Mendeloff, A. I. (1971). Archs intern. Med. 128, 411.CrossRefGoogle Scholar
Owen, J. A. & Iggo, B. (1956). Biochem. J. 62, 675.CrossRefGoogle Scholar
Pennington, R. J. (1971). Adv. clin. Chem. 14, 409.CrossRefGoogle Scholar
Peterkofsky, B. (1972). Archs Biochem. Biophys. 152, 318.CrossRefGoogle Scholar
Pope, A. L., Phillips, P. H. & Bohstedt, G. (1947). J. Anim. Sci. 6, 334.CrossRefGoogle Scholar
Porter, F. S. & Fitch, C. D. (1966). Scand. J. Haemat. 3, 175.CrossRefGoogle Scholar
Poukka, R. (1968). Br. J. Nutr. 22, 423.CrossRefGoogle Scholar
Roels, O. A. (1967). PresentKnowledge in Nutrition 3rd ed., p. 84. NewYork: The Nutrition Foundation Inc.Google Scholar
Rosalki, S. B. (1967). J. Lab. clin. Med. 69, 696.Google Scholar
Schwarz, K. & Baumgartner, W. (1969). In The Fat-Soluble Vitamins p. 317 [DeLuca, H. F. and Suttie, J. W., editors]Madison, Milwaukee and London: University of Wisconsin Press.Google Scholar
Sheriff, D., Clapp, K. H. & Reid, M. A. (1966). Aust. vet. J. 42, 169.CrossRefGoogle Scholar
Sim, A. K. (1972). Chemy Ind. no. 4, p. 160.Google Scholar
Smith, E. L. (1965). Vitamin B12 3rd ed., p. 168. London: Methuen and Co. Ltd.Google Scholar
Tappel, A. L. (1968). Geriatrics 23, no. 10, p. 97.Google Scholar
Tibbling, G. (1969). Clinica chim. Acta 23, 209.CrossRefGoogle Scholar
Turner, A. W. & Hodgetts, V. E. (1959). Aust. J. exp. Biol. med. Sci. 37, 399.CrossRefGoogle Scholar
Underwood, E. J. (1971). Trace Elements in Human and Animal Nutrition 3rd ed., p. 323. New York: Academic Press.Google Scholar
Wasserman, R. H. & Taylor, A. N. (1972). A. Rev. Biochem. 41, 179.CrossRefGoogle Scholar
Watkinson, J. H. (1966). Analyt. Chem. 38, 92.CrossRefGoogle Scholar