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Alteration of regression of cholesterol accumulation in rats by dietary pectin

Published online by Cambridge University Press:  09 March 2007

James N. Thomas ,
Michael J. Kelley  and
Jon A. Story
James N. Thomas
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Michael J. Kelley
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
Jon A. Story
Affiliation:
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907, USA
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Abstract

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1. Male, Wistar rats (50–74 g) were given a semi-purified diet containing cholesterol (10 g/kg diet) for 4 weeks, groups of control and experimental animals killed, and the remainder of the cholesterol-fed animals given either a semi-purified cholesterol-free diet without a fibre source or a similar diet with pectin (50 g/kg diet) for 8 weeks. Animals were killed at 2-week intervals and serum and liver cholesterol and triglycerides, faecal neutral steroids and acidic steroids measured.

2. Animals given pectin had significantly lower serum cholesterol levels than animals given the basal diet after 4 and 6 weeks.

3. Both experimental groups efficiently decreased their liver cholesterol levels during regression.

4. Bile acid excretion was elevated in both groups, especially in rats receiving pectin, but neutral steroid excretion was unchanged.

5. The increase in bile acid excretion was primarily in the form of chenodeoxycholic acid and its metabolites.

6. This increased bile acid excretion is postulated to result from stimulation of the normal mechanism for increased steroid excretion in the rat, i.e. a change in the value of cholic: chenodeoxycholic acid or from a mechanism not yet elucidated.

Type
Papers of direct relevance to Clinical and Human Nutrition
Information
British Journal of Nutrition , Volume 51 , Issue 3 , May 1984 , pp. 339 - 345
Copyright
Copyright © The Nutrition Society 1984

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