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Alcohol and the regulation of energy balance: overnight effects on diet-induced thermogenesis and fuel storage

Published online by Cambridge University Press:  09 March 2007

P. R. Murgatroyd ,
M. L. H. M. Van De Ven ,
G. R. Goldberg  and
A. M. Prentice
P. R. Murgatroyd
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
M. L. H. M. Van De Ven
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
G. R. Goldberg
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
A. M. Prentice
Affiliation:
MRC Dunn Clinical Nutrition Centre, Hills Road, CambridgeCB2 2DH
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Abstract

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The effect of alcohol on overnight energy expenditure and substrate disposal was studied in eleven subjects (five men, six women) using whole-body indirect calorimetry for 15·5 h after test meals. Three test meals were studied in random order with at least 48 h between treatments: control, 50% of maintenance energy needs provided as 14, 40 and 46% energy from protein, fat and carbohydrate respectively; alcohol addition, control plus 23% energy as alcohol; alcohol substitution, control with alcohol replacing 23% of carbohydrate energy. ANOVA revealed no significant sex effects. Alcoholinduced thermogenesis dissipated only 15 (SD 14)% of the alcohol energy. Alcohol addition had no significant effect on protein or carbohydrate oxidation but fat oxidation was suppressed (P < 0·0005) to an extent equivalent to storing 74 (SD 51)% of the alcohol energy as fat. Alcohol substitution reduced carbohydrate oxidation (P < 0·009) to an equivalent of 42 (SD 41)% and also spared fat (P < 0·005) to an equivalent of 59 (SD 37)% of the alcohol energy. It is concluded that alcohol has no special thermogenic capacity, and that its energy can be accounted for in a similar way to carbohydrate.

Keywords

AlcoholFat storageWhole-body calorimetry
Type
Alcohol and the regulation of energy balance
Information
British Journal of Nutrition , Volume 75 , Issue 1 , January 1996 , pp. 33 - 45
Copyright
Copyright © The Nutrition Society 1996

References

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