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Acute effects of dietary fat composition on postprandial plasma bile acid and cholecystokinin concentrations in healthy premenopausal women

Published online by Cambridge University Press:  09 March 2007

Vassiliki Costarelli  and
T. A. B. Sanders
Vassiliki Costarelli*
Affiliation:
School of Applied Science, South Bank University, 103 Borough Road, London SE1 OAA, UK Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
T. A. B. Sanders
Affiliation:
Nutrition, Food and Health Research Centre, King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, UK
*
*Corresponding author: Dr Vassiliki Costarelli, fax +44 20 7815 7934, email [email protected]
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Abstract

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Bile acids derived from intestinal bacterial metabolism and transported to the breast in plasma may influence risk of breast cancer. The purpose of the present study was to test the hypothesis that fatty acid chain length and degree of unsaturation differ with regard to their influence on the postprandial release of cholecystokinin (CCK) and the subsequent increase in plasma bile acid concentrations that occur following a meal. A randomized crossover design was used to compare five high-fat test meals (50 g fat) with a low-fat test meal (15 g) on plasma bile acid and CCK concentrations in eighteen healthy premenopausal women. The high-fat meals were enriched in oleate or palmitate, or linoleate or medium-chain triacylglycerols (MCT) or a blend of oleate and long-chain n-3 fatty acids. The postprandial increase in plasma CCK concentration was lower on the MCT meal compared with all meals and was greater following the linoleate compared with the low-fat meal. Plasma bile acid concentrations increased 2–3-fold postprandially but the increase was lower following the MCT meal compared with the other meals and was greater on the linoleate meal compared with the low-fat meal. The postprandial increases in plasma chenodeoxycholic acid concentration showed a trend to rise with increasing unsaturation of the test meal. In conclusion, meals rich in linoleate are a potent stimulus for CCK release and lead to prolonged elevations of plasma bile acids and meals containing MCT inhibit CCK release and the subsequent increase in plasma bile acid concentrations.

Keywords

Bile acidsCholecystokininDietary fatMedium-chain triacylglycerol
Type
Research Article
Information
British Journal of Nutrition , Volume 86 , Issue 4 , October 2001 , pp. 471 - 477
Copyright
Copyright © The Nutrition Society 2001

References

Baker, PR, Wilton, JC, Jones, CE, Stenzel, DJ, Watson, N & Smith, GJ (1992) Bile acids influence the growth, oestrogen receptor and oestrogen-regulated proteins of MCF-7 human breast cancer cells. British Journal of Cancer 65, 566–572.CrossRefGoogle ScholarPubMed
Bayerdorffer, E, Mannes, GA, Ochsenkuhn, T, Dirschedl, P, Wiebecke, B & Paumgartner, G (1995) Unconjugated secondary bile acids in the serum of patients with colorectal adenomas. Gut 36, 268–273.CrossRefGoogle ScholarPubMed
Beardshall, K, Frost, G, Morarji, Y, Domin, J, Bloom, SR & Calam, J (1989) Saturation of fat and cholecystokinin release: implications for pancreatic carcinogenesis. Lancet ii, 1008–1010.CrossRefGoogle Scholar
Becker, N, Illingworth, DR, Alaupovic, P, Connor, WE & Sundberg, EE (1983) Effects of saturated, monounsaturated, and omega-6 polyunsaturated fatty acids on plasma lipids, lipoproteins, and apoproteins in humans. American Journal of Clinical Nutrition 37, 355–360.CrossRefGoogle ScholarPubMed
Clayton, PT & Muller, DP (1980) A simplified gas-liquid chromatographic method for the estimation of non-sulphated plasma bile acids. Clinica Chimica Acta 105, 401–405.CrossRefGoogle ScholarPubMed
Douglas, BR, Jansen, JB, de Jong, AJ & Lamers, CB (1990) Effect of various triglycerides on plasma cholecystokinin levels in rats. Journal of Nutrition 120, 686–690.CrossRefGoogle ScholarPubMed
Feinle, C, Rades, T, Otto, B & Fried, M (2001) Fat digestion modulates gastrointestinal sensations induced by gastric distention and duodenal lipid in humans. Gastroenterology 120, 1100–1107.CrossRefGoogle ScholarPubMed
Hill, MJ, Goddard, P & Williams, RE (1971) Gut bacteria and aetiology of cancer of the breast. Lancet ii, 472–473.CrossRefGoogle Scholar
Holmes, MD, Hunter, DJ, Colditz, GA, Stampfer, MJ, Hankinson, SE, Speizer, FE, Rosner, B & Willett, WC (1999) Association of dietary intake of fat and fatty acids with risk of breast cancer. Journal of the American Medical Association 281, 914–920.CrossRefGoogle ScholarPubMed
Isaacs, PE, Ladas, S, Forgacs, IC, Dowling, RH, Ellam, SV, Adrian, TE & Bloom, SR (1987) Comparison of effects of ingested medium- and long-chain triglyceride on gallbladder volume and release of cholecystokinin and other gut peptides. Digestive Diseases Science 32, 481–486.CrossRefGoogle ScholarPubMed
Jakob, S, Mosenthin, R, Zabielski, R, Rippe, C, Winzell, MS, Gacsalyi, U, Laubitz, D, Grzesiuk, E & Pierzynowski, SG (2000) Fats infused intraduodenally affect the postprandial secretion of the exocrine pancreas and the plasma concentration of cholecystokinin but not of peptide YY in growing pigs. Journal of Nutrition 130, 2450–2455.CrossRefGoogle Scholar
Javitt, NB, Budai, K, Miller, DG, Cahan, AC, Raju, U & Levitz, M (1994) Breast-gut connection: origin of chenodeoxycholic acid in breast cyst fluid. Lancet 343, 633–635.CrossRefGoogle ScholarPubMed
Jonkers, IJ, Ledeboer, M, Steens, J, Smelt, AH & Masclee, AA (2000) Effects of very long chain versus long chain triglycerides on gastrointestinal motility and hormone release in humans. Digestive Diseases Science 45, 1719–1726.CrossRefGoogle ScholarPubMed
Jordinson, M, Beales, IL & Calam, J (1998) Soybean agglutinin stimulated cholecystokinin release from cultured rabbit jejunal cells requires calcium influx via L-type calcium channels. Peptides 19, 1541–1547.CrossRefGoogle ScholarPubMed
Kawasumi, H, Kaibara, N & Koga, S (1988) Cocarcinogenic activity of bile acids in the chemical transformation of C3H/10T1/2 fibroblasts in vitro. Oncology 45, 192–196.CrossRefGoogle ScholarPubMed
Kucio, C, Besser, P & Jonderko, K (1988) Gallbladder motor function in obese versus lean females. European Journal of Clinical Nutrition 42, 121–124.Google ScholarPubMed
Lewis, SJ & Heaton, KW (1999) The metabolic consequences of slow colonic transit. American Journal of Gastroenterology 94, 2010–2016.CrossRefGoogle ScholarPubMed
Liddle, (1997) Cholecystokinin cells. Annual Reviews in Physiology 59, 735–756.CrossRefGoogle ScholarPubMed
Mabayo, RT, Furuse, M, Yang, SI & Okumura, J (1992) Medium-chain triacylglycerols enhance release of cholecystokinin in chicks. Journal of Nutrition 122, 1702–1705.CrossRefGoogle ScholarPubMed
McLaughlin, J, Grazia, LM, Jones, MN, D'Amato, M, Dockray, GJ & Thompson, DG (1999) Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 116, 46–53.CrossRefGoogle ScholarPubMed
Mössner, J, Grumann, M, Zeeh, J & Fischbach, W (1992) Influence of various nutrients and their mode of application on plasma cholecystokinin (CCK) bioactivity. Clinical Investigation 70, 125–129.Google ScholarPubMed
Raju, U, Levitz, M & Javitt, NB (1990) Bile acids in human breast cyst fluid: the identification of lithocholic acid. Journal of Clinical Endocrinology and Metabolism 70, 1030–1034.CrossRefGoogle ScholarPubMed
Reddy, S, Sanders, TA, Owen, RW & Thompson, MH (1998) Faecal pH, bile acid and sterol concentrations in premenopausal Indian and white vegetarians compared with white omnivores. British Journal of Nutrition 79, 495–500.CrossRefGoogle ScholarPubMed
Sturdevant, RA, Pearce, ML & Dayton, S (1973) Increased prevalence of cholelithiasis in men ingesting a serum-cholesterol-lowering diet. New England Journal of Medicine 288, 24–27.CrossRefGoogle ScholarPubMed
Watabe, J & Bernstein, H (1985) The mutagenicity of bile acids using a fluctuation test. Mutation Research 158, 45–51.CrossRefGoogle ScholarPubMed